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Huang Yiqing was asked to be arrested: as a shareholder of four companies, he was arrested for rumors.

  Zhongxin Jingwei Client August 28th On the 28th, Hongkou Branch of Shanghai Public Security Bureau informed that Huang Yiqing had been arrested for drug trafficking and drug abuse. Earlier, Yi Huang Qing once said that Shanghai Economic Investigation Police acted as Zhou Libo’s "protective umbrella" and was punished by administrative detention, but later admitted that it was a fabrication.

  Hongkou Branch of Shanghai Public Security Bureau reported that Huang Yiqing, male, aged 34, was the ex-husband of actor Crystal. After being punished by the public security organs according to law for spreading false statements on the Internet, he continued to publish false statements through the Internet, and his behavior was suspected of causing trouble. On August 3, Hongkou Public Security Bureau criminally detained Huang according to law. After further investigation, the public security organs found that there were still illegal and criminal acts of selling and taking drugs to others in Yi Huang.

  According to the data of Tianyancha, Huang Yiqing is a shareholder in four companies, of which one catering management company has been revoked, one industry and trade company has been cancelled, and the other two are in a state of existence, namely Shanghai Xindongli Super Run Automobile Club Co., Ltd. and Shanghai Jiajia Investment Management Co., Ltd.

  Sky eye check screenshot

  Among them, Huang Yiqing works as a supervisor in Shanghai Xindongli Super Run Automobile Club Co., Ltd., with an investment ratio of 70%, and works as an executive director and general manager in Shanghai Jiajia Investment Management Co., Ltd. with an investment ratio of 50%. The ultimate beneficiaries of both companies are Yi Huang Qing himself.

  Sky eye check screenshot

  Sky eye check screenshot

  It is worth noting that Shanghai Yujia Catering Management Co., Ltd., of which Huang Yiqing is a shareholder, was twice listed in the list of abnormal business operations because it failed to submit the annual report information as required; And on October 17, 2016, he was administratively punished by Shanghai Fengxian District Market Supervision Administration for self-suspension for six consecutive months. (Zhongxin Jingwei APP)

Hot reading, focusing on the Fifth Plenary Session: AI takes you to read the communique in another way.

On October 29th, the Fifth Plenary Session of the 19th Central Committee of communist party, China was successfully concluded in the golden autumn. The plenary session was presided over by the Political Bureau of the Central Committee. The General Secretary of the Central Committee and the Supreme Leader made an important speech.

Information dissemination trend chart of the Fifth Plenary Session of the 19th Central Committee

High-frequency words in the communiqué of the Fifth Plenary Session of the 19th Central Committee in communist party, China

Good morning! The world wants Zelensky, and Ukraine says it is worthless; Biden awarded Yang Ziqiong the Presidential Medal of Freedom.

Russia announced that it wanted Zelensky, and Uzbekistan responded.

According to the Russian News Agency on the 4th, citing the database information of the Russian Ministry of Internal Affairs, the Russian Ministry of Internal Affairs announced that it wanted Ukrainian President Zelensky, former Ukrainian President poroshenko, Ukrainian Army Commander Pavliuc and former Minister of National Defense of Ukraine and now President of Ukrainian National Defense University Covali.

On the same day, the Ukrainian Foreign Ministry issued a statement saying that it was worthless for Russia to put Ukrainian President Zelensky on the wanted list of the Russian Ministry of Internal Affairs.

Biden awarded Yang Ziqiong the "Presidential Medal of Freedom" and said the name wrong.

According to media reports, US President Biden presented the Presidential Medal of Freedom, which represents the highest honor for American civilians, to 19 people at the White House on May 3, local time, including former US Speaker of the House of Representatives Pelosi, former US Vice President Al Gore and other Democratic allies, as well as Oscar winner Yang Ziqiong and other people in other fields.

It is worth noting that, according to the Daily Mail, Biden mistakenly called Yang Ziqiong "Michael" at first, but quickly corrected himself and changed his name to "Michelle".

South Korea’s attorney general ordered a special investigation into the incident of the "first lady" accepting famous brand bags.

South Korea’s Chosun Ilbo reported on the 4th that its reporter was informed that South Korea’s Attorney General Lee Won-suk had given instructions to the Seoul Central District Prosecutor’s Office, which was in charge of investigating the incident of South Korea’s "first lady" Jin Jianxi accepting famous brand bags, and asked to set up a special investigation team to investigate.

The report commented that after South Korea’s largest opposition party, the Common Democratic Party, won the parliamentary election, it said it would promote the investigation bill involving the "First Lady". Therefore, in this case, the South Korean procuratorate seems to have accelerated the investigation of the incident.

According to previous reports from Korean media, on September 13th, 2022, Jin Jianxi accepted a Dior bag worth about 3 million won (about RMB16,000) from Cui Zaiying, a pastor of overseas Chinese living in the United States. The related video was shot by the built-in camera of Cui Zaiying’s watch, which caused a huge storm after being exposed.

Borrell: If the West stops supplying arms, Ukraine will surrender within two weeks.

According to a report by the Tass news agency on May 3rd, Josep borrell, High Representative of the European Union for Foreign Affairs and Security Policy, admitted in a speech in Britain on the 3rd that Ukraine would surrender within two weeks if there were no weapons supplied by the West.

Borrell said, "I know how to stop the war. Just stop supplying weapons. Ukraine should surrender within two weeks after stopping the supply of weapons. But I don’t want the war to end in this way. "

According to the Tass news agency, Russian Foreign Ministry spokesman Zacharova said on the 3rd: "Great confession! This is the case with the’ peace formula’-the West stopped supplying weapons to the Kiev regime. "

The director of orthopedics at Shifa Hospital in Gaza died in Israel prison after being detained.

According to a report by the BBC and the Israel Times on the 3rd, the Palestinian Prisoners’ Association said that Adnan Al-Bosh, director of orthopedics at Shifa Hospital in Gaza, had died in an Israeli prison after being detained for more than four months.

Al-Bosh, 50, was detained by Israel for "national security reasons". Before his death, he was the director of orthopedics at Shifa Hospital, the largest medical institution in Gaza, which was repeatedly attacked by Israeli armed forces.

The Israeli prison administration did not provide the specific cause of Al-Bosh’s death, but said it was investigating the incident. The Palestinian Prisoners’ Association said that the death of Dr. Al-Bosh was an "assassination" and his body was still being detained by Israel.

Foreign media: Hamas will announce the approval of the ceasefire proposal in the next few days.

On the 4th, the Israeli Times and other foreign media quoted the Palestinian newspaper Al-Quds Al-Sharif as saying that the Palestinian Islamic Resistance Movement (Hamas) would announce its approval of the latest proposal for a ceasefire and the release of hostages in Gaza in the next few days. The report quoted Saudi media as saying that the relevant agreement is about to be reached.

According to the report, the latest proposal includes three stages. The first phase lasted for 40 days, including the release of 33 of the 128 Israeli hostages and the withdrawal of the Israel Defense Forces from parts of the Gaza; The second phase lasted for 42 days, and all other living hostages were released. The two sides continued to maintain a ceasefire in Gaza. In the third and final stage, the two sides will exchange the remains of war dead, which will also last for 42 days.

Japan’s child population hits a new low.

According to the population projection data released by the Japanese Ministry of Internal Affairs and Communications on the 4 th, as of April 1, including permanent foreigners, the population of children under the age of 15 in Japan was 14.01 million, a year-on-year decrease of 330,000; The proportion of children in Japan’s total population was 11.3%, down by 0.2 percentage points year-on-year, both of which were the lowest since statistics were made in 1950, reflecting the further intensification of the trend of declining birthrate in Japan.

According to the United Nations Demographic Yearbook, although the deadline for population projection varies from country to country, among the 37 countries with a global population of over 40 million, the proportion of children in the total population in Japan ranks second from the bottom, only higher than that in South Korea.

Japan and the United States plan to spend huge sums of money to jointly develop hypersonic weapon interceptor missiles.

According to Japan’s "Daily News" reported on May 3, the Missile Defense Agency of the US Department of Defense revealed that the cost of jointly developing hypersonic weapons interceptor missiles estimated by the Japanese and American governments will exceed $3 billion. Among them, Japan will bear $1 billion, responsible for the development of interceptor missile propulsion system and other parts, and plans to achieve the goal in the mid-2030 s.

According to reports, Japan and the United States plan to intercept a hypersonic missile that separates the warhead after the rocket is launched to a certain height and can rise and fall repeatedly while taxiing. Although the existing interception system can deal with the missile in the final stage, Japan and the United States jointly developed a new interception system at the summit meeting last August to reach an agreement on interception in the taxiing stage before the final stage.

The Petroleum Committee of Sharjah, United Arab Emirates announced the discovery of new natural gas reserves.

The Petroleum Committee of Sharjah, United Arab Emirates announced on May 4th local time that new natural gas reserves have been discovered in Al Hadiba oil field in Sharjah. Sharjah National Oil Company discovered this new gas field after drilling a well in the past few months, which will be tested in the next few days to confirm its potential natural gas reserves.

The highest temperature is 48.2℃, and Myanmar experienced the hottest April on record.

Recently, Myanmar has experienced rare extreme high temperature weather. According to the latest data released by the Myanmar Meteorological and Hydrological Bureau, the past April has become the hottest April since Myanmar’s own temperature record.

According to meteorological data, in April this year, the daily maximum temperature in more than 10 areas of Myanmar exceeded the historical record of local weather stations. Magway Province and mandalay province, which are located in the middle, have even been included in the list of the hottest areas in the world for many times.

In Qiaozhen, Magway province, the temperature was as high as 48.2℃, which was not only the highest temperature in April measured by the local weather station in 56 years, but also the highest temperature record in Myanmar.

(Yangcheng Evening News Yangcheng School Comprehensive CCTV News, Xinhua News Agency, The Paper, vision china, Global Times, Reference News Network, etc.)

Foreign media are worried that "killing robots" will move towards autonomy and urge the introduction of bans to restrict research and development.

The reference news network reported on December 17. The US media said thatWeapons that can kill people without direct human participation, the so-called "lethal autonomous weapons" will soon appear.

According to the US Forbes biweekly website reported on December 15, on September 14, 2019, a small number of drones attacked the Hureis oil field and the Bougueg refinery in Saudi Arabia. In addition to disrupting 5% of the world’s crude oil production, the attack also highlighted some challenges brought by the use of these remote-controlled weapons.

The report said that the first is that it is difficult to be accountable. Nearly three months after the incident, it is still unclear who made the attack. Like hackers in cyber warfare, the attackers left almost no trace. Another problem is that such weapons are small in size and relatively low in cost, so they may be attractive to a small group of militants or terrorists and some countries.

The report said that this is scary enough. However, in view of the current development direction of the arms industry, these concerns cannot be compared with those that may arise in the future.

As the Dutch NGO "Peace" pointed out in a report published a few weeks ago, the world is on a dangerous path, and those weapons that can kill people without direct human participation, the so-called "lethal autonomous weapons", will soon appear. The more common name of this kind of weapon is "killing robot".

According to the report, this nickname is misleading to some extent, reminiscent of fantasy things such as "Terminator" in science fiction movies. In fact, these tools are similar to more traditional deadly devices: unmanned combat aircraft, tanks, submarines; What has changed is not the shape of the weapon, but its degree of autonomy. At present, completely autonomous offensive weapons have not been deployed in actual combat, but machines are becoming more and more advanced, and the dependence on human control is decreasing.

Profile picture: T-800 hunting robot in the sci-fi movie Terminator. (Forbes biweekly website)

Profile photo: The Turkish "Cargou" attack four-axis UAV was unveiled at the exhibition. (Turkish Ministry of Defence website)

One example is the "Cargou" autonomous attack four-axis UAV developed by the Turkish state-owned enterprise STM. According to reports, it will be deployed in the border area adjacent to Syria in eastern Turkey in 2020. According to an article in the Turkish newspaper Freedom, each "Cargou" fleet will consist of 30 drones, all of which are equipped with artificial intelligence and facial recognition systems. Depending on the coordinates or images of the target, these Cargou UAVs will be able to complete all tasks autonomously. Fortunately, human operators can still choose to "abort the mission" and "return to the base" at all stages of the drone attack.

According to the report, Russia’s T-14 Amata main battle tank is equipped with unmanned turrets and computerized systems, so it is often regarded as another equipment case that will soon achieve complete autonomy-although some people doubt whether this will really make it more effective on the battlefield.

Perhaps not coincidentally, countries such as Russia, Israel and the United States strongly oppose banning the development of "killing robots" in advance. The United Nations discussed the issue of pre-banning such weapons at a meeting in Geneva in November.

As The New York Times pointed out in a recent special report, the measures to ban blinding laser weapons in advance were successful. Therefore,Theoretically, this ban may also apply to "killing robots". The general public awareness and strong support for the ban may change the situation, which is what is missing at present.

[Extended reading] Lifting the ban on "killing robots"? The US military AI development strategy involves ethical disputes.

The reference news network reported on February 15. According to the British "Daily Mail" website reported on February 14th, the US military hopes to expand the application of artificial intelligence (AI) in the war, but said that it will pay attention to the deployment of this technology according to national values.

According to the report, in a 17-page report, the Pentagon explained how to inject artificial intelligence into future military operations and how to keep up with the technological progress of Russia and China in the future.

The report entitled "Using Artificial Intelligence to Promote Our Security and Prosperity" marks the first time that the Pentagon has formulated a strategy on how to deal with the rise of artificial intelligence.

The strategic plan calls for accelerating the use of artificial intelligence systems in the whole army and carrying out a series of tasks, from intelligence gathering actions to predicting maintenance problems of fighter planes or ships. It urges the United States to rapidly advance such technologies before they are weakened by other countries.

"Other countries, especially China and Russia, are also investing heavily in artificial intelligence for military purposes, including those applications that have been questioned by the outside world in terms of international norms and human rights," the report said.

The report makes little mention of automated weapons, but quotes a military directive in 2012 that requires manual control. A few countries, including the United States, have been obstructing the international community from setting a ban on "killing robots" at the United Nations. One day, this completely autonomous weapon system may wage war without human intervention.

The United States believes that it is too early to try to regulate "killing robots".

The report believes that the strategic report released by the Pentagon this week focuses on more immediate applications, but even some of them have triggered ethical debates.

After Google’s internal protests led the technology company to withdraw from the Maven project last year, the Pentagon encountered obstacles in the field of artificial intelligence. Maven project is to analyze aerial images of conflict areas by using algorithms.

Other companies are trying to fill this vacuum, and the Pentagon is working with artificial intelligence experts in industry and academia to formulate ethical guidelines for their artificial intelligence applications.

Todd Probert, vice president of artificial intelligence department of Raytheon, said: "Everything we see is decided by human decision makers."

Probert said: "The project is using technology to help speed up this process, but it has not replaced the existing command structure."

(2019-02-15 10:29:27)

[Extended reading] Expert warning: Killing robots may lead to an arms race or lead to the massacre of civilians.

The reference news network reported on November 21. The British "Star Daily" website published a report entitled "The Killing Robot Arms Race" on November 17th.

An artificial intelligence expert revealed that the United States, Britain, Russia, Israel and other countries are involved in a competition to build a killing robot army.

From self-shooting guns and drones to remote-controlled super tanks, prototype robots in the United States and Russia have been successfully built and ready to go. And humanoid robots on the battlefield will only appear in a few decades-and outline a terrible prospect for the world.

Noel sharky, honorary professor of artificial intelligence and robotics at the University of Sheffield in the UK, told SciDev.Net: "An arms race has begun."

Sharky said: "What we are seeing now is that the United States, Israel and Russia (the killing robot arms race) has begun. If these things appear, then they may accidentally trigger war at any time. "

He also said: "How can we ban them? You can put these things on hold forever, but they only need to be recharged to start again. "

Nowadays, artificial intelligence robots are setting off a craze around the world. Professor sharky is worried that the research and development of killing robots may also have such an amazing speed. Therefore, he is leading a global movement to ban killing robots.

After this website disclosed the latest development-American robots do backflips-the expert warned that the latest project in Russia was "absolutely frightening".

Sharky said: "There is something terrible … The Russians have developed this thing called’ super tank’, and it is the most advanced tank in the world, which is much ahead. It is definitely a monster with great destructive power, and they can remotely control it. They are still trying to turn it into a fully automatic robot at the fastest speed. "

Although autonomous armed robots are ahead of humanoid robots for many years, Professor sharky is worried that the possible humanoid robots may bring disaster to the world-leading to the massacre of civilians.

When warning about the terrible consequences of killing robots, Professor sharky said: "This can’t be in line with the laws of war. Can they distinguish whether a target is a military target or a civilian target? This is the key to the law of war. "

He said: "It is also not allowed to kill people who try to surrender. I know that many people think that surrender means raising a white flag, but actually surrender means any gesture that shows that you are no longer fighting, such as lying on the ground unarmed … but robots can’t distinguish this. My biggest personal concern is what kind of damage this will cause to global security-because an arms race for such weapons has already begun. "

Profile picture: American robot that can do backflips. (British "Star Daily" website)

(2017-11-21 10:14:24)

[Further reading] German media said that the United Nations wanted to restrain the development of "killing robots" so far without results.

The reference news network reported on November 16. According to the German Daily Mirror website reported on November 13th, in the near future, completely autonomous killing robots will decide people’s life and death on the battlefield. Discussions on prohibiting or at least restricting the use of such weapon systems have not stopped in recent years, but so far there is no result. The United Nations recently began discussions on this issue in Geneva.

What is a killing robot?

Its official name is "lethal autonomous weapon system". At present, there is no universally valid definition. The United Nations and the International Red Cross explain it this way: it can set targets, launch attacks and clear targets without human help. In other words, once programmed, these weapon systems can independently analyze data, navigate to the combat area and use weapons such as cannons or rockets. In recent years, the great progress in the field of artificial intelligence constitutes the basis for the development of killing robots.

The drone that is already in use is still controlled by soldiers, so it is not a killing robot. Although it doesn’t seem far away from its independent operation.

How far has it developed?

Russian Deputy Prime Minister rogozin, who is in charge of armament, released a video this spring, in which a humanoid killing robot like Terminator can be seen. This is more of a propaganda category. It doesn’t matter whether the appearance is similar to that of human beings. Experts from Human Rights Watch believe that "the autonomy of weapon systems developed by the United States, Britain, China, Israel, Russia and South Korea is increasing". At present, there are already prototypes in use.

Supporters argue that it will minimize the danger of soldiers. But this may lead to the lowering of the threshold and the increase of wars-thus leading to more civilian casualties. People can already see this development in the use of remotely controlled drones.

The picture shows a military drone equipped in the United States.

Who will bear the consequences?

This is a fundamental ethical issue that is inseparable from the killing robot. Ethical and moral actions, the distinction between good and evil, right and wrong, the evaluation of the consequences, and the responsibility for one’s own actions all do not exist in future wars. Although the robot has artificial intelligence, it has no feelings such as pity or regret, and it has no sense of guilt. It has no way to start with concepts such as moderation. But this is written in the so-called law of war: the parties to the conflict must avoid unnecessary damage and unnecessary pain to each other. We must be kind to civilians, injured, incapacitated and captured soldiers. Experts believe that this cannot be programmed. In 2013, policy experts warned in a report to the United Nations Commission on Human Rights that these "tireless war machines" may turn armed conflicts into endless wars-diplomacy will not be able to stop the killing of machines dedicated to fighting even if there is no hope.

How to establish legal norms?

So far, no. This UN conference will not legislate, but will only explore its political, ethical and legal space in a "political statement". A ban is out of the question.

Since these systems do not actually exist at present, Germany and France propose to define autonomous weapon systems first. A group of technical experts, including military representatives, will explain the risks of new weapons. The representative of the "International Campaign to Stop Killing Robots" thinks that this is not enough, and these weapons must be banned in advance.

Only 19 countries have asked for a ban. Behind the scenes, it is precisely the countries that are leading in integrating artificial intelligence with combat equipment. Recently, more than 100 experts wrote in an open letter that killing robots are the third combat revolution after gunpowder and nuclear bombs. If new weapons fall into the hands of tyrants and terrorists, what awaits people will be complete terror.

(2017-11-16 09:31:00)

(Editor: Wang Zhiqiang HF013)

Embrace the river and embrace the sea, integrate into Nantong, Shanghai, and accelerate the construction of ocean centre city with river and sea characteristics in China

       Cctv news The reporter learned from the series of press conferences on "Promoting the High-quality Development of Coastal Areas" held on August 5th that in recent years, Nantong has cooperated to promote the integrated development of Hong Kong, industry and city, innovated and implemented the system and mechanism of Greater tongzhou bay, accelerated the construction of new seaports in an all-round way, made great efforts to break through major industrial projects, and entered the "fast lane" of a new round of rapid development. Since the State Council approved the Jiangsu Coastal Area Development Plan (2021-2025) in December last year, Nantong has systematically promoted the objectives and tasks of coastal development and accelerated the construction of a ocean centre city with rivers and seas.

  In promoting industrial transformation, upgrading and development, Nantong insists that projects are king and focuses on the development of port-based industries. Since last year, Greater tongzhou bay has signed a total of 62 projects with a total investment of 177.3 billion yuan, including 6 projects of 10 billion yuan; Twenty-five projects with a total investment of 80 billion yuan were started, including 4 projects of 10 billion yuan. The output value of five industrial clusters, such as marine engineering, high-end textiles, new materials, new generation information technology and high-end equipment, all exceeded 100 billion yuan, and the taxable sales of industry and service industry exceeded one trillion yuan. The total marine production accounts for more than 1/2 and 1/4 of the three coastal cities and the whole province respectively.

  Nantong has made great efforts to build a new seaport in Jiangsu and a new hub for river-sea combined transport in the Yangtze River Economic Belt, and achieved important results. The master plan of Nantong Port was successfully approved, the "2+2" terminal in Lvsi Port Area was completed and put into operation, the "2+1" terminal in the main port area was successfully started, and the collection and transportation projects such as Yanglu Railway were comprehensively promoted. A series of major projects such as Nantong New Airport, high-speed railway along the Yangtze River in the north, and new seaport in tongzhou bay have been included in the national strategy. Nantong has been listed as a "1+8" city in Shanghai metropolitan area, and the Shanghai-Suzhou Bridge, Yantong high-speed railway and Haiqi Expressway have been opened to traffic one after another, which highlights the advantages of embracing the river and embracing the sea and integrating into Shanghai.

  Shanghai, north of Nantong, and new southern Jiangsu are targeted, and the construction of the pilot zone for cross-river integration and development between Shanghai and Soviet Union will be fully promoted, and a number of industrial cooperation parks between Shanghai and southern Jiangsu will be built, further enhancing the degree of urbanization and integration. According to the data, in the first half of this year, two-thirds of Nantong’s newly recruited projects came from Shanghai and southern Jiangsu. More than 50% of enterprises have long-term and stable cooperation with enterprises in Shanghai and southern Jiangsu, and 70% of listed manufacturing enterprises have carried out innovative cooperation with 80% of universities and colleges in Shanghai.

  (Headquarters reporter Lu Dongxin, Wang Hao Nan)

Consumption before the holiday | Shantou, Guangdong: Sales volume tripled before the Spring Festival. Beef ball processing factory was busy with orders.

CCTV News:Our reporter learned in the interview that before the Spring Festival, the factory is the busiest time of the year. There are still ten days before the Spring Festival. What about the production and sales in chaoshan beef meatball?

Near the evening, the reporter saw at the entrance of this beef shop in Shantou that there was an endless stream of citizens who came to buy beef and beef balls, many of whom bought the goods of the year and sent them to relatives and friends.

The person in charge of the beef shop said that in the twelfth lunar month, business is getting better every day, and the current sales volume is three times that of usual. Chaoshan people eat cattle for freshness, so they have to work overtime to sell beef during the Spring Festival, and in order to ensure the stable supply during the Spring Festival, they have already paid the deposit to the slaughterhouse in advance.

Affected by the epidemic, large-scale catering parties have been reduced, and the purchase of beef balls by restaurants has decreased. At the same time, the terminal retail and family consumption of beef balls have increased significantly.

China has achieved the goal of clearing the import of solid waste by the end of 2020 as scheduled.

  "I can tell you that developed countries regard China as ‘ Garbage dump ’ The history is gone forever. " On 18th, Huang Runqiu, Minister of Ecology and Environment, introduced at the press conference held by the State Council Press Office that the CPC Central Committee and the State Council attached great importance to prohibiting foreign garbage from entering the country and promoting the reform of solid waste import management system. After four years of hard work, various reform tasks have been successfully completed, and the goal of clearing solid waste imports by the end of 2020 has been achieved as scheduled. (Reporter: Gao Jing, photography: Li Xin)

Beijing’s second ring road exit adds a solid line probe to treat "unruly"!

Cctv newsThe Second Ring Road in Beijing is a road with a very large traffic volume, but individual drivers are unwilling to queue at the exit of the ring road for their own convenience, and continue to merge, forcibly merge or even jam. Recently, the traffic control department of Beijing has made "articles" on several exits of the main road of the Second Ring Road, aiming at those unruly drivers.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauNow we are at Fuchengmen Bridge. The south exit of Fuchengmen Bridge is the most important exit from the north to Financial Street. Many cars merge from the middle lane or the innermost lane to the exit, which directly affects the traffic of the whole West Second Ring Road. Every morning rush hour is affected by this exit, and vehicles can queue up all the way to Xizhimen Bridge.

In order to standardize the traffic order at the entrance and exit sections of the Second Ring Road, as well as the auxiliary roads along the route, and solve the outstanding problems of congestion and vehicle queue-jumping at the exit sections of the Second Ring Road, the Beijing Traffic Control Department has made overall planning and transformation of the relevant exit sections, and customized specific transformation plans according to the road conditions of each exit. By improving the exit warning signs, adding snapshot monitoring equipment, drawing solid lanes, removing isolation barriers and other measures, the exit traffic order is standardized and traffic congestion is alleviated.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauThe inner two lanes are marked with solid lane lines that prohibit merging, so as to reduce the interweaving of vehicles. Vehicles that need to go to Financial Street are merged from Fuchengmen Bridge North to the outer lane in advance to ensure the normal driving of the inner two lanes, thus improving the overall traffic of our West Second Ring Road.

According to statistics, up to now, the traffic control department of Beijing has drawn solid exit lines and lane lines at seven exits, such as the high-speed exit of the outer ring airport of the Second Ring Road, the exit of Xiwai Street and the south exit of Fuchengmen Bridge, and three exits, such as the north exit of Fuxingmen Bridge, the high-speed exit of the airport and the south exit of Jianguomen Bridge, in the inner ring road of the Second Ring Road, which has improved the warning signs. In view of the problem of traffic jam at the exit, some illegal monitoring devices are installed on the basis of the comprehensive utilization of the original monitoring equipment, and the two straight lanes inside are guaranteed not to be affected by the exit section by standardizing the vehicle driving path. The police suggested that the driver should pay attention to the change of the marking line of the exit sign of the loop and plan the route in advance.

Analysis and Prospect of Global Pharmaceutical Market in 2017-2022

I. Market size and growth rate

the year 2017The global prescription drug market size is$774 billion, estimated from 2017 to 2022.The annual growth rate of CAGR is 6.5%By 2022, the prescription drug market will exceed the trillion-dollar level for the first time, reaching$1.06 trillion. CAGR exceeds that in the field of instruments5.1%.

Prescription drug market is divided intoPrescription drugs (except generic drugs and Orphan drugs), generic drugs and orphan drugs.Three market segments. Among them,generic drugsIn 2017-2022, the scale of the overall prescription drug market will be10%-11%The annual growth rate of CAGR is slightly lower than that of the overall prescription drug market.6.0%The market scale will be from 2017.$84 billionGrowing to 2022$112 billion; Annual growth rate of orphan drugs in 2017-2022CAGR was 11.2%, a rare double-digit growth, the market size will be from 2017.$123 billionrise to$209 billion, accounting for the overall prescription drug market size will be from15.9% in 2017rise to19.7% in 2022.

Although the expected market share can be increased, in fact, the proportion will remain basically unchanged in the next five years; The proportion of orphan drugs has steadily increased.

2. What is the impact of the patent cliff?

It is expected to be from 2017 to 2022.$194 billionThe drug market is facingPatent cliff patent cliffThe challenge is mainly due toBiosimilar, a biosimilarIn the previous article, I also shared the market of Biosimilar, the global biosimilar market and competition analysis |Q said. This patent cliff may be fromThe first patent cliff in 2012After the second patent cliff peak.

Of course, there are still some variables in the future who will eat this big cake in the generic drug market. In addition to companies that focus on generic drugs,Big pharmaceutical companiesNow I have also found a way. If my patented drug expires, I can authorize it to be authorized generics, which is exactly the same as the original patented drug, except that the trademark is removed and the price is lower, and the regulatory authorities do not have to work hard to approve it. Regarding the definition of Authorized Generics, FDA gives the following explanation.

The term “authorized generic” drug is most commonly used to describe an approved brand name drug that is marketed without the brand name on its label. Other than the fact that it does not have the brand name on its label, it is the exact same drug product as the branded product.An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. In some cases, even though it is the same as the brand name product, a company may choose to sell the authorized generic at a lower cost than the brand name drug.

Many big pharmaceutical companies have begun to plan this.Instead of letting others eat the cake, it is better to distribute it yourself or share it with others.; The time and method of specific sales are also controllable; Why not?

III. What are the hot treatment areas? 

fromFrom the perspective of Biotech, a biological medicine, and Conventional medicine, Conventionality.Look, 2017-2022Biological medicineThe proportion of the overall market has steadily increased and tends to be flat, and will be from26% in 2017 increased to 30% in 2022.; At the same time, biopharmaceutical head productsTop 100 productsThe proportion of total biopharmaceuticals is from 2016.49%Increased to 202252%.

fromTreatment areaLooking at it, the following ten areas have the largest market scale.

(1)Oncology of tumorIt is still the largest market segment, with CAGR in 2016-2022.12.7%Will reach in 2022.$192.2 billionSales, accounting for global market share17.5%.

(2)Diabetes Anti-diabeticsIt is the second largest market segment, with CAGR in 2016-2022.4.8%Will reach in 2022.$57.9 billionSales, accounting for global market share5.3%.

(3)Rheumatism Anti-rheumaticsIt is the third largest market segment, with CAGR in 2016-2022.0.6%Will reach in 2022.$55.4 billionSales, accounting for global market share5.0%.

(4)be antiviralAnti-virusIt is the fourth largest market segment, with CAGR in 2016-2022.-2.1%Will reach in 2022.428Billion dollarsSales, accounting for global market share3.9%. fornegative growthSo Gilead is nervous.

(5)Vaccine VaccinesIt is the fifth largest market segment, with CAGR in 2016-2022.4.2%Will reach in 2022.353Billion dollarsSales, accounting for global market share3.2%.

(6)Bronchodilators of respiratory system bronchusIt is the sixth largest market segment, with CAGR in 2016-2022.1.0%Will reach in 2022.301Billion dollarsSales, accounting for global market share2.7%.

(7)Sensory organsIt is the seventh largest market segment, with CAGR in 2016-2022.five.8%Will reach in 2022.283Billion dollarsSales, accounting for global market share2.6%.

(8)Immunosuppressant ImmunosuppresantsIt is the eighth largest market segment, and the CAGR in 2016-2022 is14.6%Will reach in 2022.263Billion dollarsSales, accounting for global market share2.4%. This field is one of all fields.The fastest growth rateYes.

(9) Hypertension Anti-hypertensives is the ninth largest market segment, and the CAGR in 2016-2022 is-0.2%Will reach in 2022.244Billion dollarsSales, accounting for global market share2.2%.

(10)Cardiovascular Anti-coagulantsIt is the tenth largest market segment, and the CAGR in 2016-2022 iseight.6%Will reach in 2022.232Billion dollarsSales, accounting for global market share2.1%.

By 2022,Top Five Top5 Tumor DrugsWill beCelgeneThe company’s immunomodulatorRevlimidBMScorporatePD1 antibody Opdivo, Merck’sPD1 antibody KeytrudaAbbViecorporateBTK inhibitor ImbruvicaPfizercorporateCDK inhibitor Ibrance. The next five years will bePD1The overbearing world adds up to the tumor market.10%.

4. How much does it cost to develop new drugs?

First of all, the big pharmaceutical companiesAt present, R&D investment has accounted for about 20% of the sales revenue ratio.. Without research and development, there will be no new products, and cruel competition will push you out of the market.

Secondly,On average, each new drug NME(New Molecular Entity) costs $5 billion.. $5 billion is definitely not a small figure, which exceeds the previous cost.

Furthermore, according to the sales in the United States after the approval of the new drug,The annual sales of each NME in the fifth year is about $522 million.. According to the current Hacth-waxman Act, the new drug NME has5 years of data exclusivityandThree years of market exclusivity, After that, generic drugs went on the market. It is necessary for pharmaceutical companies to expand indications, conduct more research and development, or cooperate in research and development as soon as possible.

5. Who are the top ten pharmaceutical companies?

First place,Novartis NovartisIn 2016-2022, CAGR is3%, sales reached in 2022.49.8 billion dollars, accounting for market share4.7%.

Second place,Pfizer PfizerIn 2016-2022, CAGR is1%, sales reached in 2022.49.7 billion dollars, accounting for market share4.7%.

Third place,Roche RocheIn 2016-2022, CAGR is4%, sales reached in 2022.$49.6 billion, accounting for market share4.7%.

Fourth place,Sanofi sanofiIn 2016-2022, CAGR is3%, sales reached in 2022.$41.7 billion, accounting for market share3.9%.

Fifth place,Johnson&JohnsonIn 2016-2022, CAGR is4%, sales reached in 2022.$40.5 billion, accounting for market share3.8%.

Sixth place,Merck&CoIn 2016-2022, CAGR is1%, sales reached in 2022.$38.5 billion, accounting for market share3.6%.

Seventh place,AbbVie in AbbwayIn 2016-2022, CAGR is5%, sales reached in 2022.$34 billion, accounting for market share3.2%.

Eighth place,GlaxoSmithKlineIn 2016-2022, CAGR is3%, sales reached in 2022.$33.7 billion, accounting for market share3.2%.

Ninth place,AstraZeneca AstraZenecaIn 2016-2022, CAGR is5%, sales reached in 2022.$28.4 billion, accounting for market share2.7%.

Tenth place,Xinji pharmaceutical CelgeneIn 2016-2022, CAGR is15%, sales reached in 2022.$26 billion, accounting for market share2.5%.

It can be seen that the top three are very tight, and the rankings have not changed much. Pfizer has retreated to the second place, Novartis has jumped to the first place, and Roche is still firmly in the third place.

Gilead fell out of the top ten.

Celgene jumped 11 places into the top ten.

This article was originally published on WeChat WeChat official account’s "Investment and Life of the Owner of Q Village".

A large car of 919,000 yuan that is suitable for driving home for the New Year, which one is the most worth choosing?

The change in shape design is still relatively positive, and the new model looks more fashionable. The lower grille is enlarged and matched with the "BMW" logo, which makes the gas field of the front face of the vehicle look domineering, and the slender headlights look very energetic after being lit. Judging from the waistline on the side of the car body, the new car is still a solemn appearance, and the tradition of wide C-pillar can be continued. In addition, with the design of 20-inch multi-frame wheels, its sports atmosphere is more intense. The horizontal development of the duck tail with two long and slender taillights is more stable, and the details of the through taillights have become more beautiful after being redrawn.

In the car, the new car adopts BMW’s latest design style and layout, which is very harmonious as a whole. Configuration is definitely one of the strengths of BMW 7 Series. The car is equipped with an electric four-way adjustable leather steering wheel and a shift paddle, which is very practical. The center console is made of plastic and leather, and the materials and workmanship look quite satisfactory. The front row is also equipped with a dual-temperature automatic air conditioning control system to freely debug the most comfortable space atmosphere. Leather seats look cute.

The length of the BMW 7 Series is 5391mm, the body width is 1950mm and the wheelbase is 3215mm, which is quite satisfactory. In the same class, the wheelbase of the BMW 7 Series ranks 12th. As a car, its body size does not occupy much advantage in its class, and its internal seating space is only basically enough. After all, it is limited by the length and shape of the car body. The design of skylight also increases the subjective space feeling of front and rear passengers. Among the models of the same price and class, the trunk volume of BMW 7 Series ranks 23rd. Spatial performance is limited by vehicle positioning, and the performance is acceptable, and the flatness is no problem, but the total space is average.

The BMW 7 Series is equipped with a combination of 3.0 turbocharged engine (direct injection) and automatic manual (AT). The power performance of 3.0 engine matched with BMW 7 Series is quite satisfactory, the low torque is weak and the hysteresis can be felt. The official measured acceleration of the BMW 7 Series is 5.4S, ranking 20th among more than 800,000 car models.

The active/passive safety configuration of BMW 7 Series is complete, includingAutomatic parkingZero tire pressure endurance tireAutomatic parkingSteep slope descenthill start assist controlknee airbagHUD head-up displayAnti-lock braking (ABS)Braking force distribution (EBD/CBC, etc.)Brake assist (EBA/BAS, etc.)Traction control (ASR/TCS, etc.)Active noise reductionEngine start and stopSide safety air curtainWireless charging of mobile phonenight vision systemLED daytime running lightsForward reversing radarTire pressure monitoringSteering wheel heatingBody stability control (ESP/DSC, etc.)Rear reversing radarFatigue reminderRemote parkingChild seat interfaceLane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

If the above data and participation can’t fully understand the BMW 7 Series, then we can give you a more comprehensive reference based on the word-of-mouth information of users who have purchased the BMW 7 Series in history. It can be seen that what everyone is most satisfied with the BMW 7 Series is that its acceleration is very stable. In addition, the interior is very good and the seats are delicate, which is what everyone likes about it.