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Huang Yiqing was asked to be arrested： as a shareholder of four companies, he was arrested for rumors.

　　Zhongxin Jingwei Client August 28th On the 28th, Hongkou Branch of Shanghai Public Security Bureau informed that Huang Yiqing had been arrested for drug trafficking and drug abuse. Earlier, Yi Huang Qing once said that Shanghai Economic Investigation Police acted as Zhou Libo’s "protective umbrella" and was punished by administrative detention, but later admitted that it was a fabrication.

　　Hongkou Branch of Shanghai Public Security Bureau reported that Huang Yiqing, male, aged 34, was the ex-husband of actor Crystal. After being punished by the public security organs according to law for spreading false statements on the Internet, he continued to publish false statements through the Internet, and his behavior was suspected of causing trouble. On August 3, Hongkou Public Security Bureau criminally detained Huang according to law. After further investigation, the public security organs found that there were still illegal and criminal acts of selling and taking drugs to others in Yi Huang.

　　According to the data of Tianyancha, Huang Yiqing is a shareholder in four companies, of which one catering management company has been revoked, one industry and trade company has been cancelled, and the other two are in a state of existence, namely Shanghai Xindongli Super Run Automobile Club Co., Ltd. and Shanghai Jiajia Investment Management Co., Ltd.

　　Sky eye check screenshot

　　Among them, Huang Yiqing works as a supervisor in Shanghai Xindongli Super Run Automobile Club Co., Ltd., with an investment ratio of 70%, and works as an executive director and general manager in Shanghai Jiajia Investment Management Co., Ltd. with an investment ratio of 50%. The ultimate beneficiaries of both companies are Yi Huang Qing himself.

　　Sky eye check screenshot

　　It is worth noting that Shanghai Yujia Catering Management Co., Ltd., of which Huang Yiqing is a shareholder, was twice listed in the list of abnormal business operations because it failed to submit the annual report information as required; And on October 17, 2016, he was administratively punished by Shanghai Fengxian District Market Supervision Administration for self-suspension for six consecutive months. (Zhongxin Jingwei APP)

Consumption before the holiday ｜ Shantou, Guangdong： Sales volume tripled before the Spring Festival. Beef ball processing factory was busy with orders.

CCTV News:Our reporter learned in the interview that before the Spring Festival, the factory is the busiest time of the year. There are still ten days before the Spring Festival. What about the production and sales in chaoshan beef meatball?

Near the evening, the reporter saw at the entrance of this beef shop in Shantou that there was an endless stream of citizens who came to buy beef and beef balls, many of whom bought the goods of the year and sent them to relatives and friends.

The person in charge of the beef shop said that in the twelfth lunar month, business is getting better every day, and the current sales volume is three times that of usual. Chaoshan people eat cattle for freshness, so they have to work overtime to sell beef during the Spring Festival, and in order to ensure the stable supply during the Spring Festival, they have already paid the deposit to the slaughterhouse in advance.

Affected by the epidemic, large-scale catering parties have been reduced, and the purchase of beef balls by restaurants has decreased. At the same time, the terminal retail and family consumption of beef balls have increased significantly.

Beijing’s second ring road exit adds a solid line probe to treat ＂unruly＂!

Cctv newsThe Second Ring Road in Beijing is a road with a very large traffic volume, but individual drivers are unwilling to queue at the exit of the ring road for their own convenience, and continue to merge, forcibly merge or even jam. Recently, the traffic control department of Beijing has made "articles" on several exits of the main road of the Second Ring Road, aiming at those unruly drivers.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauNow we are at Fuchengmen Bridge. The south exit of Fuchengmen Bridge is the most important exit from the north to Financial Street. Many cars merge from the middle lane or the innermost lane to the exit, which directly affects the traffic of the whole West Second Ring Road. Every morning rush hour is affected by this exit, and vehicles can queue up all the way to Xizhimen Bridge.

In order to standardize the traffic order at the entrance and exit sections of the Second Ring Road, as well as the auxiliary roads along the route, and solve the outstanding problems of congestion and vehicle queue-jumping at the exit sections of the Second Ring Road, the Beijing Traffic Control Department has made overall planning and transformation of the relevant exit sections, and customized specific transformation plans according to the road conditions of each exit. By improving the exit warning signs, adding snapshot monitoring equipment, drawing solid lanes, removing isolation barriers and other measures, the exit traffic order is standardized and traffic congestion is alleviated.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauThe inner two lanes are marked with solid lane lines that prohibit merging, so as to reduce the interweaving of vehicles. Vehicles that need to go to Financial Street are merged from Fuchengmen Bridge North to the outer lane in advance to ensure the normal driving of the inner two lanes, thus improving the overall traffic of our West Second Ring Road.

According to statistics, up to now, the traffic control department of Beijing has drawn solid exit lines and lane lines at seven exits, such as the high-speed exit of the outer ring airport of the Second Ring Road, the exit of Xiwai Street and the south exit of Fuchengmen Bridge, and three exits, such as the north exit of Fuxingmen Bridge, the high-speed exit of the airport and the south exit of Jianguomen Bridge, in the inner ring road of the Second Ring Road, which has improved the warning signs. In view of the problem of traffic jam at the exit, some illegal monitoring devices are installed on the basis of the comprehensive utilization of the original monitoring equipment, and the two straight lanes inside are guaranteed not to be affected by the exit section by standardizing the vehicle driving path. The police suggested that the driver should pay attention to the change of the marking line of the exit sign of the loop and plan the route in advance.

Analysis and Prospect of Global Pharmaceutical Market in 2017-2022

I. Market size and growth rate

the year 2017The global prescription drug market size is$774 billion, estimated from 2017 to 2022.The annual growth rate of CAGR is 6.5%By 2022, the prescription drug market will exceed the trillion-dollar level for the first time, reaching$1.06 trillion. CAGR exceeds that in the field of instruments5.1%.

Prescription drug market is divided intoPrescription drugs (except generic drugs and Orphan drugs), generic drugs and orphan drugs.Three market segments. Among them,generic drugsIn 2017-2022, the scale of the overall prescription drug market will be10%-11%The annual growth rate of CAGR is slightly lower than that of the overall prescription drug market.6.0%The market scale will be from 2017.$84 billionGrowing to 2022$112 billion; Annual growth rate of orphan drugs in 2017-2022CAGR was 11.2%, a rare double-digit growth, the market size will be from 2017.$123 billionrise to$209 billion, accounting for the overall prescription drug market size will be from15.9% in 2017rise to19.7% in 2022.

Although the expected market share can be increased, in fact, the proportion will remain basically unchanged in the next five years; The proportion of orphan drugs has steadily increased.

2. What is the impact of the patent cliff?

It is expected to be from 2017 to 2022.$194 billionThe drug market is facingPatent cliff patent cliffThe challenge is mainly due toBiosimilar, a biosimilarIn the previous article, I also shared the market of Biosimilar, the global biosimilar market and competition analysis |Q said. This patent cliff may be fromThe first patent cliff in 2012After the second patent cliff peak.

Of course, there are still some variables in the future who will eat this big cake in the generic drug market. In addition to companies that focus on generic drugs,Big pharmaceutical companiesNow I have also found a way. If my patented drug expires, I can authorize it to be authorized generics, which is exactly the same as the original patented drug, except that the trademark is removed and the price is lower, and the regulatory authorities do not have to work hard to approve it. Regarding the definition of Authorized Generics, FDA gives the following explanation.

The term “authorized generic” drug is most commonly used to describe an　approved brand name drug that is marketed without the brand name on its label. Other than the fact that it does not have the brand name on its label, it is the　exact same drug product as the branded product.An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. In some cases, even though it is the same as the brand name product, a company may choose to sell the authorized generic　at a lower cost　than the brand name drug.

Many big pharmaceutical companies have begun to plan this.Instead of letting others eat the cake, it is better to distribute it yourself or share it with others.; The time and method of specific sales are also controllable; Why not?

III. What are the hot treatment areas?　

fromFrom the perspective of Biotech, a biological medicine, and Conventional medicine, Conventionality.Look, 2017-2022Biological medicineThe proportion of the overall market has steadily increased and tends to be flat, and will be from26% in 2017 increased to 30% in 2022.; At the same time, biopharmaceutical head productsTop 100 productsThe proportion of total biopharmaceuticals is from 2016.49%Increased to 202252%.

fromTreatment areaLooking at it, the following ten areas have the largest market scale.

（1）Oncology of tumorIt is still the largest market segment, with CAGR in 2016-2022.12.7%Will reach in 2022.$192.2 billionSales, accounting for global market share17.5%.

（2）Diabetes Anti-diabeticsIt is the second largest market segment, with CAGR in 2016-2022.4.8%Will reach in 2022.$57.9 billionSales, accounting for global market share5.3%.

（3）Rheumatism Anti-rheumaticsIt is the third largest market segment, with CAGR in 2016-2022.0.6%Will reach in 2022.$55.4 billionSales, accounting for global market share5.0%.

（4）be antiviralAnti-virusIt is the fourth largest market segment, with CAGR in 2016-2022.-2.1%Will reach in 2022.428Billion dollarsSales, accounting for global market share3.9%. fornegative growthSo Gilead is nervous.

（5）Vaccine VaccinesIt is the fifth largest market segment, with CAGR in 2016-2022.4.2%Will reach in 2022.353Billion dollarsSales, accounting for global market share3.2%.

（6）Bronchodilators of respiratory system bronchusIt is the sixth largest market segment, with CAGR in 2016-2022.1.0%Will reach in 2022.301Billion dollarsSales, accounting for global market share2.7%.

（7）Sensory organsIt is the seventh largest market segment, with CAGR in 2016-2022.five.8%Will reach in 2022.283Billion dollarsSales, accounting for global market share2.6%.

（8）Immunosuppressant ImmunosuppresantsIt is the eighth largest market segment, and the CAGR in 2016-2022 is14.6%Will reach in 2022.263Billion dollarsSales, accounting for global market share2.4%. This field is one of all fields.The fastest growth rateYes.

(9) Hypertension Anti-hypertensives is the ninth largest market segment, and the CAGR in 2016-2022 is-0.2%Will reach in 2022.244Billion dollarsSales, accounting for global market share2.2%.

（10）Cardiovascular Anti-coagulantsIt is the tenth largest market segment, and the CAGR in 2016-2022 iseight.6%Will reach in 2022.232Billion dollarsSales, accounting for global market share2.1%.

By 2022,Top Five Top5 Tumor DrugsWill beCelgeneThe company’s immunomodulatorRevlimid、BMScorporatePD1 antibody Opdivo, Merck’sPD1 antibody Keytruda、AbbViecorporateBTK inhibitor Imbruvica、PfizercorporateCDK inhibitor Ibrance. The next five years will bePD1The overbearing world adds up to the tumor market.10%.

4. How much does it cost to develop new drugs?

First of all, the big pharmaceutical companiesAt present, R&D investment has accounted for about 20% of the sales revenue ratio.. Without research and development, there will be no new products, and cruel competition will push you out of the market.

Secondly,On average, each new drug NME(New Molecular Entity) costs $5 billion.. $5 billion is definitely not a small figure, which exceeds the previous cost.

Furthermore, according to the sales in the United States after the approval of the new drug,The annual sales of each NME in the fifth year is about $522 million.. According to the current Hacth-waxman Act, the new drug NME has5 years of data exclusivityandThree years of market exclusivity,　After that, generic drugs went on the market. It is necessary for pharmaceutical companies to expand indications, conduct more research and development, or cooperate in research and development as soon as possible.

5. Who are the top ten pharmaceutical companies?

First place,Novartis NovartisIn 2016-2022, CAGR is3%, sales reached in 2022.49.8 billion dollars, accounting for market share4.7%.

Second place,Pfizer PfizerIn 2016-2022, CAGR is1%, sales reached in 2022.49.7 billion dollars, accounting for market share4.7%.

Third place,Roche RocheIn 2016-2022, CAGR is4%, sales reached in 2022.$49.6 billion, accounting for market share4.7%.

Fourth place,Sanofi sanofiIn 2016-2022, CAGR is3%, sales reached in 2022.$41.7 billion, accounting for market share3.9%.

Fifth place,Johnson&JohnsonIn 2016-2022, CAGR is4%, sales reached in 2022.$40.5 billion, accounting for market share3.8%.

Sixth place,Merck&CoIn 2016-2022, CAGR is1%, sales reached in 2022.$38.5 billion, accounting for market share3.6%.

Seventh place,AbbVie in AbbwayIn 2016-2022, CAGR is5%, sales reached in 2022.$34 billion, accounting for market share3.2%.

Eighth place,GlaxoSmithKlineIn 2016-2022, CAGR is3%, sales reached in 2022.$33.7 billion, accounting for market share3.2%.

Ninth place,AstraZeneca AstraZenecaIn 2016-2022, CAGR is5%, sales reached in 2022.$28.4 billion, accounting for market share2.7%.

Tenth place,Xinji pharmaceutical CelgeneIn 2016-2022, CAGR is15%, sales reached in 2022.$26 billion, accounting for market share2.5%.

It can be seen that the top three are very tight, and the rankings have not changed much. Pfizer has retreated to the second place, Novartis has jumped to the first place, and Roche is still firmly in the third place.

Gilead fell out of the top ten.

Celgene jumped 11 places into the top ten.

This article was originally published on WeChat WeChat official account’s "Investment and Life of the Owner of Q Village".

Strictly crack down on illegal registration of real estate! Ministry of Natural Resources： Strictly prevent the legalization of small property houses.

　　CCTV News:At present, the real estate registration system has been fully operated in the whole country. During a period of operation, there are some difficulties in obtaining certificates in real estate registration in some places. Recently, the Ministry of Natural Resources has deployed a special rectification of the style of the real estate registration window throughout the country.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of the unified registration system for real estate, there have been 109 halls in China, and there have been problems of queuing in the early morning and scalpers changing their numbers. Some places have turned a blind eye to the gap between the service ability and level and the people’s demand for permits, and have not taken the initiative to solve it in time, which is simply limited."

　　The rectification deployment focuses on the style of real estate registration window, such as "pushing around and dragging" and "difficulty in obtaining a certificate". It will take three months to comprehensively promote the "reduction of certificates and convenience for the people" nationwide, and clean up and cancel the pre-existing links without legal and regulatory basis. At the same time, it is necessary to comprehensively clean up all kinds of unnecessary certificates such as "wonderful" certificates, circular certificates and repeated certificates that bother enterprises and the masses.

　　Wang Guanghua, Vice Minister of Natural Resources: "Those materials that can be obtained through the Internet shall not be submitted repeatedly by the masses. Then in fact, the information that can be obtained through information sharing between government departments is fast, accurate and reliable, so it is beneficial to improve efficiency and ensure quality. "

　　In terms of establishing a standardized service system in an all-round way, the Ministry of Natural Resources said that all localities should classify and establish standardized and simplified standardized business processes to provide clear guidance for the masses to do things.

　　Wang Guanghua, Vice Minister of Natural Resources: "There is no pre-position for real estate registration. As long as the application materials submitted by the applicant meet the requirements of the provisional regulations on real estate registration and the detailed rules for the implementation of the provisional regulations on real estate registration, the real estate registration agency should handle it, and the sharing and collaboration between departments should be placed in the window. Don’t let the people run back and forth."

　　Issues left over from history should not be shelved for a long time.

　　According to the Ministry of Natural Resources, for the multi-sector decentralized registration period before the implementation of unified registration of real estate, historical problems caused by imperfect and irregular management links should not be shelved for a long time.

　　Wang Guanghua, Vice Minister of Natural Resources: "At present, there are still more than 4.8 million pieces in the country, and the problems left over from the history of decentralized registration have not been solved. In some places, in the face of the outbreak of historical problems, they did not organize forces to focus on investigation and coordination, and directly let the window staff respond, simply because the procedures were incomplete and they could not be handled."

　　According to the Ministry of Natural Resources, all localities should actively discuss and study the problems left over from history with planning, housing construction and other departments, and report to the people’s governments of cities and counties to issue policies to solve them in time to meet the people’s normal demand for accreditation.

　　Strictly investigate violations of laws and regulations for real estate registration　

　　In addition, the Ministry of Natural Resources also emphasized that it is necessary to prevent "small property houses" from being legalized through real estate registration. At the same time, it is necessary to crack down on the abuse of power to forge false registration of materials, deliberately misregister, illegally register for financing, maliciously collude with illegal registration and disclose registration information.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of real estate registration, a total of 303 cases of illegal registration have been found throughout the country. In recent years, the state land supervision agency found that some places illegally and falsely registered mortgages for public welfare roads, parks, public facilities and other land for financing needs, and some places maliciously colluded with third parties to register illegally and leaked registration information."

National Health Commission： Strengthen the coordinated development of medical insurance and medicine

At the press conference held by the National Health and Wellness Committee on February 28th on the progress and effectiveness of health and wellness, Mi Feng, spokesperson of the Committee and deputy director of the Propaganda Department, introduced that the main health indicators of Chinese residents are currently in the forefront of middle-and high-income countries.

Continuously meet the health service needs of the people.

Zhuang Ning, deputy director of the Department of Physical Reform of the National Health and Wellness Commission, said that in recent years, the National Health and Wellness Commission has actively played a leading and coordinating role in medical reform and strengthened the coordinated development of medical care, medical insurance and medicine with relevant departments.

Zhuang Ning introduced that in terms of medical care, through the layout and construction of national medical centers, national regional medical centers, and provincial regional medical centers, we will strengthen relevant clinical key specialties and solve the problem of people seeking medical treatment across regions. According to statistics, in the first four batches of 76 national regional medical centers, more than 460 specialties have been built and more than 6,200 new medical technologies have been developed, and the average number of patients transferred to hospitals has dropped by about 30% compared with that before construction. The rate of common and frequently-occurring diseases in the county is over 90%.

Public hospitals are the main body of China’s medical service system. According to Jiao Yahui, director of the Department of Medical Administration of the National Health and Wellness Commission, there are 2,817 tertiary public hospitals and 5,384 secondary public hospitals participating in the performance appraisal of public hospitals nationwide. According to the data of the past five years, the development mode, operation mode and resource allocation of tertiary public hospitals in China are more reasonable. The two indexes reflecting the technical difficulty of medical services, namely, the case combination index and the proportion of discharged patients in Grade IV surgery, have increased by 10% and 23.5% respectively, and the application level of electronic medical records in 83% tertiary public hospitals has reached Grade IV or above. The number and proportion of doctors in short supply such as anesthesiology, pediatrics, and severe diseases in tertiary public hospitals across the country have increased, constantly meeting the needs of people’s health services.

Zhuang Ning said that in terms of medical insurance, China has further improved the universal medical insurance system, raised the per capita financial subsidy standard for residents’ medical insurance to 640 yuan, and continuously improved the level of general outpatient medical insurance for employees. In medicine, we will further expand the breadth and depth of centralized procurement of pharmaceutical consumables and further reduce the inflated price. Revise and improve the medical insurance drug list, improve the basic drug system, speed up the registration and listing of urgently needed drugs, children’s drugs and innovative medical devices, and strive to meet the people’s drug demand.

Continuously improve the ability of disease prevention and control

In recent years, China has continuously improved the multi-sectoral cooperation mechanism to enhance the ability of disease prevention and control. Qin Xingqiang, deputy director of the Comprehensive Department of the National Bureau of Disease Control and Prevention, said that the laws, regulations and policy systems related to the emergency response of infectious diseases in China have been continuously improved, and the emergency management system and mechanism have been continuously optimized, basically forming an emergency plan for public health emergencies, covering multiple diseases and covering national, provincial, municipal and county levels. Relying on the national and provincial centers for disease control and prevention, 20 national teams for the prevention and control of sudden acute infectious diseases have been set up, covering 17 provinces.

According to reports, since the "14 th Five-Year Plan", the central budget has allocated a total of 13.1 billion yuan to support the construction of disease control systems at the national, provincial, municipal and county levels. In 2023, the central government allocated 17.687 billion yuan for disease control projects through transfer payment for the prevention and control of major infectious diseases and endemic diseases.

Qin Xingqiang said that at present, the average reporting time of China’s infectious disease network direct reporting system has been shortened from five days to four hours now. At the national level, a technical system for rapid identification of 300 pathogens within 72 hours has been established, and 100% of provincial and 90% of municipal CDC have the ability to detect nucleic acids and isolate viruses. In the prevention and control of major infectious diseases, the rapid rise of AIDS epidemic in key areas has been effectively curbed; The mortality rate of tuberculosis remains at a low level; All endemic counties of schistosomiasis have reached the state of transmission interruption; Measles, Japanese encephalitis and other vaccines can prevent the incidence of infectious diseases from falling to the lowest level in history.

Construction of 321 high-level key disciplines of traditional Chinese medicine

In order to promote the development of China’s traditional Chinese medicine service system, Ouyang Bo, deputy director of the Comprehensive Department of the State Administration of Traditional Chinese Medicine, introduced that the State Administration of Traditional Chinese Medicine, the National Health and Wellness Commission and the National Development and Reform Commission took the lead in establishing an inter-departmental working mechanism with relevant departments, and the central government invested nearly 13 billion yuan to promote key tasks and major engineering projects to basically achieve "double half".

Ouyang Bo said that China’s traditional Chinese medicine inheritance and innovation has been steadily promoted-46 national traditional Chinese medicine inheritance and innovation centers have been built, and 50 superior diseases treated by traditional Chinese medicine, 52 integrated Chinese and Western medicine diagnosis and treatment programs, 100 appropriate technologies and 100 Chinese medicine varieties with unique curative effects have been selected and released. The official publication of the first batch of 74 books in the "Chinese Medical Collection" marks a major stage achievement in the compilation of ancient Chinese medicine books.

At the same time, the team of talents with Chinese medicine characteristics has been growing, training 50 Qihuang scholars, 500 national outstanding clinical talents of Chinese medicine, 100 young Qihuang scholars, 35 innovative teams of Chinese medicine, and building 321 high-level key disciplines of Chinese medicine.

According to preliminary estimates, in 2023, the total number of medical treatment in Chinese medical and health institutions was 1.28 billion, and the number of discharged patients was 41.486 million. Chinese medicine played an active role in serving people’s health.

Building a high-quality and efficient Chinese medicine service system is one of the main tasks of the development plan of Chinese medicine in the 14 th Five-Year Plan. In this regard, Ouyang Bo said that the State Administration of Traditional Chinese Medicine aims to achieve high-quality Chinese medicine services for everyone nearby, promote 14 Chinese medicine hospitals to be included in the founding unit of the National Medical Center, lay out and build 27 national regional medical centers for Chinese medicine, and continue to promote the construction of 62 "flagship" hospitals and 138 key hospitals with Chinese medicine characteristics. At the same time, optimize the supply of Chinese medicine services, select about 1,000 national traditional Chinese medicine specialties and 500 "flagship" departments for the coordination of Chinese and Western medicine, determine 31 units for the construction of Chinese medicine rehabilitation centers, strengthen the construction of pediatrics and geriatrics departments in Chinese medicine hospitals, and promote the construction of outpatient clinics for Chinese medicine specialties; Taking the construction of county-level Chinese medicine hospitals as the leader, we will build a solid grassroots network, promote tertiary hospitals to help 699 county-level Chinese medicine hospitals, and achieve full coverage of grassroots Chinese medicine museums in 23 provinces, so as to facilitate the masses to take a good look at Chinese medicine at their doorsteps.(Reporter Jin Zhenya)

Korean media： Former South Korean President Lee Myung-bak, who is serving his sentence, is hospitalized outside the prison due to illness.

　　[Global Network Report] Yonhap News Agency reported that according to the news of the Korean Ministry of Justice on the 17th, former President Lee Myung-bak, who was detained in Anyang Prison in Gyeonggi Province, was admitted to Seoul National University Hospital the day before for a disease check-up, and the time of hospitalization, discharge and escort was inconvenient to disclose due to security problems.

Profile photo: Li Mingbo was transferred to Anyang Prison. Image source: Yonhap News Agency

　　The Korean Ministry of Justice said that Lee Myung-bak will be examined according to the opinions of the hospital during his hospitalization. According to the report, Lee Myung-bak was treated for diabetes and other diseases, and he was treated outside prison for three times last year. According to reports, Lee Myung-bak was sentenced to 17 years in prison for corruption and bribery, fined 13 billion won (about 69.24 million yuan), and pursued 5.78 billion won in criminal proceeds.

　　It is worth mentioning that another former South Korean President, park geun-hye, was released from prison by amnesty at the end of December, 2021. Her lawyer, Liu Rongxia, said on the 16th that park geun-hye was in better health and would speak to the people when she left the hospital. Liu Rongxia also relayed that park geun-hye was sad that another former president, Lee Myung-bak, was not granted amnesty.

Hualong No.1 demonstration project completed in an all-round way ｜ China’s advanced nuclear power has achieved a technological breakthrough in the whole industry chain, and the reliability of Hualong

　　CCTV News:It is understood that Fuqing Nuclear Power Unit 5, the first Hualong No.1 unit in China, has been put into commercial operation for more than a year, and its power generation has exceeded 7 billion kWh. At present, the first refueling work has been successfully completed, which has fully verified the reliability of Hualong No.1 technology.

　　As the world’s first Hualong No.1 unit, Fuqing Nuclear Power Unit 5 has just completed its first refueling overhaul. In order to ensure the long-term safe and reliable operation of nuclear power units, nuclear power units need to replace nuclear fuel regularly, and during this period, important equipment should be inspected and maintained. This work is called overhaul. At present, the unit has completed the loading of nuclear fuel components and is about to start the second start.

　　The world’s first reactor, Hualong No.1, was officially put into commercial operation on January 30, 2021, which achieved a technological breakthrough in the whole industrial chain of independent design, manufacture, construction and operation of China’s advanced nuclear power. After running for more than a year, it has been running smoothly and normally, without unplanned shutdown, which fully verified the reliability of Hualong technology.

Hebei： The two forecasting services are as accurate and timely.

　　China Meteorological News correspondent Xie Pan Li Haiqing

　　After entering July, the rain came one after another, which put Hebei meteorological disaster prevention and mitigation mechanism to the test and made people constantly think about the construction of disaster prevention and mitigation mechanism.

　　Department linkage makes flooding invisible.

　　"The’ July 21′ precipitation was the biggest since the establishment of the meteorological observatory in Zhuozhou in 1957, but it realized the miracle that no one was killed or injured. The meteorological disaster prevention mechanism led by the government, departmental linkage and social participation played a decisive role. " Liu Yingfeng, director of the Zhuozhou Meteorological Bureau, said.

　　Zhuozhou Flood Control and Drought Relief Headquarters was built in the Municipal Meteorological Bureau. Through information cooperation and resource sharing, with the goal of preventing severe floods, fighting severe droughts and grabbing major risks, Zhuozhou actively built a modern and information-based flood control and drought relief command platform, and built five systems, namely decision-making command, video consultation, real-time monitoring, early warning release and logistics support.

　　On July 19th and 20th, Zhuozhou Meteorological Bureau sent important precipitation weather report information to more than 120 leaders of municipal party committee, municipal government, 15 townships, offices and development zones and 29 related departments such as flood control and meteorological disaster prevention through the early warning release system.

　　On the afternoon of 21st, at the beginning of precipitation, Wang Zhou, secretary of the municipal party committee and political commissar of the flood control and drought relief headquarters, and Zhu Ziqiang, mayor and commander of the flood control and drought relief headquarters, rushed to the flood control and drought relief headquarters at the first time and quickly entered an emergency state.

　　At 3 am on the 22nd, the precipitation ended. No one was killed or injured in 69 villages in Zhuozhou flood detention area. "When the’ July 21′ torrential rain occurred, Baoding’s practices of accurate forecasting, timely warning and rapid transfer of people played an important role and were successful experiences in effectively coping with disasters." Zhang Qingwei, deputy secretary of Hebei Provincial Party Committee and governor, spoke highly of it.

　　
　　Internal and external training makes the prevention more detailed.

　　From July 27th to 29th, strong precipitation hit most of Hebei again. On the evening of 27th, Li Xingwen, director of Chengde Meteorological Bureau, closely monitored the weather changes with the personnel on duty, and provided rolling rain warning service to the government, flood control, information officers and relevant departments according to the rainstorm monitoring system.

　　From the evening of 28th, the strong convective weather in Tangshan began to strengthen. At 2100 hours, more than 50 mm of precipitation occurred in the northern part of Tangshan, reaching 100 mm in some areas. The Tangshan Meteorological Observatory issued an orange rainstorm warning signal.

　　In Qinhuangdao, Liu Jian, director of the Municipal Meteorological Bureau, requested that during the precipitation process, the meteorological department release the latest rainfall situation, the weather forecast for the next two hours and the short-term weather forecast for the next 24 hours every hour, and report them to the command center of the Municipal Flood Control Office by fax, email and SMS.

　　Late at night on the 28th, heavy precipitation gradually stopped. Shen Xiaoping, deputy governor of Hebei Province, was pleased to say to Yao Xuexiang, director of the Provincial Meteorological Bureau: "These two forecasts are as wonderful as meteorological services!"

　　Since 2010, disaster prevention has been more targeted through the implementation of "process reengineering" project, detailed disaster prevention process, timely consultation and communication, real-time monitoring of rain conditions and disasters, normal operation of regional automatic stations, and close cooperation between meteorological information personnel, assistants and meteorological disaster prevention responsible persons.

　　Eliminating difficulties in popular science and making defense more effective

　　A rainstorm makes people pay more attention to meteorological forecast and early warning, and at the same time, how to prevent meteorological disasters in production and life has become a topic of public concern.

　　"While strengthening meteorological forecasting and early warning, we must do a good job in popular science propaganda, so that the people can understand the forecasting and early warning signals and take precautions in time." On 25th, Zhang Qingli, secretary of the Hebei Provincial Party Committee and director of the Standing Committee of the Provincial People’s Congress, and other leaders made it clear when they inspected the disaster situation in Laishui.

　　"At present, Hebei has entered the peak season, and strong convective weather such as short-term heavy rain and lightning frequently occurs. Here, we will explain the rainstorm warning signal and the way to get the warning signal in detail." A Weibo was posted in time by "Hebei Weather", and fans scrambled to reprint it.

　　On the Hebei Weather Network, the contents of rainstorm warning signal interpretation, risk avoidance and self-help measures are added, which are linked with local mainstream media to let more people know.

　　On the 27th, Zhang Qingwei, vice governors Song Enhua and Shen Xiaoping called Yao Xuexiang, director of the Provincial Meteorological Bureau, respectively: the release of meteorological early warning information has been greatly improved in terms of frequency, content and coverage, and a series of effective measures have been taken to publicize meteorological science knowledge in response to heavy rain, which further enhanced the pertinence and effectiveness of services, and fully understood and implemented the requirements and deployment of the provincial party committee and government on this work.

　　Promoting performance management and exploring the source of consolidation

　　From July 20 to 28, heavy precipitation occurred frequently in Hebei, and the rainfall of several rainfall stations exceeded 200 mm, causing serious economic losses to some areas.

　　How to avoid or reduce the losses caused by meteorological disasters more effectively? How to improve the fortification ability of remote rural areas, so that the tragedy of urban disaster risk reduction and people trapped in floods can not save themselves will not be staged again?

　　Taking performance management as the starting point, Hebei Province has continuously improved the meteorological disaster prevention mechanism led by the government, coordinated by departments and participated by the society, so as to improve the level of meteorological disaster prevention.

　　State Council document No.33 pointed out that it is necessary to strengthen monitoring and early warning from the government and relevant departments of disaster prevention and mitigation, and continuously improve the accuracy of forecasting; Establish a wide coverage and rapid meteorological early warning information distribution network; Form an effective emergency linkage of meteorological disaster prevention and mitigation.

　　"To carry out performance management of meteorological disaster prevention and mitigation is to improve the ability of meteorological disaster prevention and eliminate potential safety hazards." This is the feeling that Liu Yuhu, director of Baoding Meteorological Bureau, promoted this work.

　　(Editor: Sun Wei)

Flora, the health guard in the intestine

There are more than 10 trillion huge microbial groups in human skin and intestines, and their number is more than 10 times of the total number of human cells, which is considered as another set of genomes besides human cells. Under normal circumstances, the vast majority of bacteria in the gastrointestinal tract are beneficial to the human body, but due to various factors, the intestinal flora will also be unbalanced, and once it is unbalanced, it is easy to induce various chronic diseases.

The second organ of the human body

We collectively refer to the bacteria living in the intestine as intestinal flora. Their total weight in the human body is 2~3 kg, and there are more than 1,000 species. More than 50% of the feces we excrete every day are composed of these bacteria and their corpses. These small bacteria are symbiotic with our human body. They are rooted in the intestine for a long time to maintain our health, so we also call the intestinal flora "the second organ of the human body".

First of all, intestinal flora can shield and influence the immune system by itself, and prevent pathogenic bacteria from invading the human body. Intestinal flora adheres to the mucosal layer on the surface of the inner wall of the intestine, forming a barrier composed of bacteria. Intestinal flora inhibits the growth of pathogenic bacteria through the dominant symbiotic bacteria activities, and prevents pathogenic bacteria from entering the human body through this barrier. At the same time of passive defense, intestinal flora can stimulate the body to form more lymphatic organs in the intestine, and increase the level of immunoglobulin in plasma and intestinal mucosa, so that the immune system is in a moderately active state, so as to maintain an effective immune effect on invading pathogens.

In addition, intestinal flora has regulating and nutritional effects on the intestine. It has been reported that the existence of intestinal flora, especially the nutritional function of short-chain fatty acids produced by it, can make the growth of intestinal epithelial cells more active. In addition, intestinal flora can also regulate the differentiation of intestinal mucosal epithelial cells. This means that with normal intestinal flora, intestinal mucosa can be repaired more quickly.

Recent studies have shown that intestinal flora has an important relationship with human metabolic diseases. In addition, there are many other relationships between intestinal flora and health. Carotenoids produced by intestinal flora can reduce the risk of atherosclerosis and stroke to some extent. Normal intestinal flora can regulate the body’s response to allergens through the influence on lymphocytes, thus affecting the occurrence of allergic diseases. Even more surprising, there is evidence that the structural changes of intestinal flora can even affect the behavior patterns of the body.

Bacteria are also divided into good and bad

"Bacteria exceeded the standard" and "food was found to have bacteria" … People often talk about "bacteria" discoloration, but they don’t know that bacteria are also good or bad. Microbial communities are constantly influenced by many factors in the process of growth, including heredity, age, gender, diet and lifestyle. Everyone’s intestinal microbes have their own characteristics, but in healthy individuals, the relative abundance and distribution of bacterial species are very similar, and they all play a role in maintaining people’s overall health. There are "beneficial bacteria" that provide positive energy, "harmful bacteria" that love to make trouble, and some originally harmless bacteria that may take advantage of the situation and cause harm to the body. Such bacteria are called "opportunistic pathogens" or "conditional pathogens".

The normal flora of gastrointestinal tract can be divided into aerobic bacteria, facultative anaerobic bacteria and anaerobic bacteria. The most dominant is anaerobic bacteria, accounting for 99% of the total flora. The types and quantities of bacteria in the stomach, duodenum and jejunum are less, and the bacteria in the ileum begin to increase. In the colon, the types and quantities of bacteria increase more significantly, most of which are anaerobic bacteria, and Bifidobacterium, Bacteroides and Lactobacillus are absolutely dominant, while Clostridium and Staphylococcus, which are potentially pathogenic, account for only a few.

The imbalance of flora leads to many diseases.

If the intestinal flora is out of balance, health will go wrong. When beneficial bacteria can’t compete with harmful bacteria or conditional pathogens, they show bacterial infection, and symptoms of gastrointestinal diseases such as diarrhea, abdominal pain, vomiting and fever appear. For example, the endotoxin produced by the imbalance of intestinal flora will increase the burden of liver detoxification and cause liver damage. These toxins will also enter our brain, causing abnormal brain development, causing autism, depression, Alzheimer’s disease and other symptoms. In addition, the imbalance of intestinal flora will also lead to cardiovascular and cerebrovascular diseases such as atherosclerosis.

There are five main reasons for the imbalance of intestinal flora: 1. Long-term unbalanced diet. For example, eating too much meat or vegetables and eating unhealthy food for a long time; 2. Ingestion of food contaminated by bacteria. Reduce resistance, make conditional pathogens "worse", or ingest too many harmful bacteria, imbalance of intestinal flora, and diarrhea symptoms; 3. Age increases. With the increase of age, some beneficial bacteria decrease and harmful bacteria increase, and the body’s immunity weakens; 4. Use certain drugs. Excessive use of antibiotics leads to imbalance of intestinal flora and decreased immunity; 5. Gastrointestinal dysfunction. Organic causes lead to imbalance of intestinal flora and decreased immunity.

Diet regulation is safe and effective.

Now we have a safe, effective and scientific conditioning method, that is, taking microecological preparations. This preparation mainly includes three types, namely probiotics, prebiotics and synbiotics. Probiotics contain a certain number of live bacteria preparations; Prebiotics can promote the growth of intestinal probiotics; Synbiotics is a mixture of probiotics and prebiotics, which can not only supplement the probiotics in our body, but also promote the growth of probiotics.

Yogurt is a good choice to supplement probiotics. It contains plenty of protein, and also contains Lactobacillus bulgaricus and Streptococcus thermophilus, but these two kinds of bacteria can’t colonize in our intestines, and yogurt at room temperature contains no live bacteria.

In addition to yogurt, there are many lactic acid bacteria drinks on the market at present. This kind of drink has a very high sugar content, and its nutritional value is relatively low compared with yogurt. Moreover, most of these drinks are stored at room temperature, so it does not contain live bacteria.

There is also an active lactic acid bacteria beverage, which requires strict cold chain transportation and cold storage. However, for people with gastrointestinal discomfort, drinking cold drinks often stimulates the intestines, and there is no way to guarantee the probiotic activity contained in such drinks.

In addition, bad eating habits will destroy the balance of intestinal flora, for example, a high-fat diet will change the intestinal flora. Adjusting the dietary structure and developing good eating habits play an important role in maintaining the dynamic balance of intestinal flora.

Intestinal flora changes with age, and some studies show that the number of bifidobacteria in the intestine of the elderly is significantly reduced. Therefore, in the diseases related to intestinal flora imbalance in the elderly, proper application of microecological agents is conducive to the recovery of the health of the elderly.

Commonly used microecological agents include live bacterial agents such as Bifidobacterium, Lactobacillus and Enterococcus. Increasing the number of beneficial bacteria can not only regulate the balance of intestinal flora, but also enhance the immunity of the body. ▲ (This lecture was written by Cui Yuyan, a special correspondent of this newspaper)

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