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Overseas Chinese pay New Year greetings to the people of the whole country.

　　"Touching people, don’t worry about love first." On the occasion of the annual Spring Festival, overseas Chinese who are far away from home pay a New Year call to the people of the whole country through this newspaper, congratulating China on its "Thirteenth Five-Year Plan" and all the work of the Party and the country on a new level, and wishing the people of the whole country happiness in the new year, China more prosperity and new achievements in the great journey of building a well-off society in an all-round way.

　　Asia — —

　　I sincerely hope that the development path of China will be wider and wider.

　　New Year greetings to people of all ethnic groups in China and overseas Chinese at home and abroad. I wish you all a good year of the Rooster and good health! In the past year, under the leadership of Chairman of the Supreme Leader, China has made all-round progress in economy, politics, culture, society and ecological civilization, and its development achievements are remarkable. The "Belt and Road" construction has achieved fruitful results, and countries along the route have benefited a lot, and China’s international status has been continuously improved. Overseas Chinese feel the same way about every progress made in China, and sincerely hope that China will continue to make new and greater achievements.

　　— — Huang Bin, Director of Chinese Department of Kaitai Research Center in Thailand.

　　Happy New Year to the people of China, and wish you all good luck, health and happiness in the New Year! Under the correct leadership of the Supreme Leader, China is developing with each passing day. Overseas Chinese are full of confidence in the future of their ancestral home country, and sincerely hope that the road of China’s development will be wider and wider!

　　The "One Belt, One Road" initiative put forward by the Chairman of the Supreme Leader is conducive to promoting the common development of Southeast Asian countries and jointly building a community of human destiny. The rise of China has shown the image of a great country to the whole world and provided a rare opportunity for the development of neighboring countries. Since the second half of last year, the relationship between the Philippines and China has achieved a "gorgeous turn" and the cooperation between the two countries has become increasingly close. I hope that the Philippines can take the "Belt and Road" development express train in time and become an important partner along the route to realize its rapid development.

　　— — Zhang Zhaohe, Chairman of the Philippine Chinese Chamber of Commerce.

　　Africa — —

　　The locomotive function of China economy is becoming more and more obvious.

　　The past year has been a historic year in the development of China-Egypt relations. The visit of the Supreme Leader to Egypt has pushed China-Egypt cooperation to a new height. I have worked hard in Egypt for many years, and I have personally felt the increasing pragmatic cooperation between China and Egypt in various fields, and I have also felt that China is becoming stronger and richer. On the occasion of the arrival of the Spring Festival, I wish the people of the whole country a happy New Year, and wish China prosperity and new achievements in the great journey of building a well-off society in an all-round way. Let’s roll up our sleeves and work hard, and life will be better in the future!

　　— — Chen Jiannan, President of Egypt China Peaceful Reunification Promotion Association and Egyptian Chinese Friendship Council

　　Although it’s a long way, overseas Chinese in South Africa are connected with their native countries. We hope that China will develop better and better. As President Xi said, we will roll up our sleeves and make more contributions to building a well-off society in an all-round way in the new year. Overseas Chinese in South Africa will continue to safeguard the overall situation of China-South Africa friendship and cooperation. In 2016, the global economy is sluggish, and the locomotive role of China’s economy is becoming more and more obvious, which is true for the South African economy and more important for overseas Chinese in South Africa. Happy new year to the people of the whole country, and wish you all a happy and healthy New Year!

　　— — Yan Hai, President of Shanghai Chamber of Commerce and Industry in Southern Africa

　　Europe — —

　　The development of China has given us great confidence and enthusiasm.

　　In 2016, the motherland made great achievements. The G-20 Hangzhou Summit was held, the China women’s volleyball team regained the Olympic champion podium, and the successful launch of Tiangong-2 made overseas students and overseas Chinese feel excited and happy, and Russian friends around them also congratulated them. The development of the motherland has given us great confidence and enthusiasm. More and more Russian friends let their children and grandchildren learn Chinese, shop on Taobao and travel to China.

　　This year, I helped the Russian Ministry of Education and Science to organize summer camps for young people of the two countries. The exchanges between young people of the two countries ignited the desire of the younger generation in Russia to learn more about China and planted seeds for the deepening of friendship between the two countries. I hope to continue to contribute to the development of bilateral relations in the new year. I wish the people of the motherland a happy New Year, the country is prosperous and the people are happy and healthy!

　　— — Yin Bin, Vice Chairman of Russian Federation of College Graduates

　　Chairman Supreme Leader met with overseas Chinese representatives during his state visit to Germany in 2014, and I had the honor to attend. In his speech, President Xi encouraged overseas Chinese living in Germany to cherish their motherland and integrate into the local area. For more than two years, we have consciously paid more attention to the two-way nature of public diplomacy in our activities, and listened to others’ voices while making our own "voices".

　　This year marks the 45th anniversary of the establishment of diplomatic relations between China and Germany. China will usher in the 19th National Congress of the Communist Party of China, and Germany will host the G20 Summit, and a series of high-level visits will be conducted between the two countries. On the occasion of the Chinese New Year in the Year of the Rooster, I would like to extend my best wishes to the people of all ethnic groups in China, and wish China prosperity, prosperity and national security! I wish people of all ethnic groups a happy holiday and all the best!

　　— — Yang Qianghua, President of German Overseas Chinese Public Diplomacy Association

　　The most exciting moment for me in 2016 is to welcome the Chairman of the Supreme Leader to visit Serbia. President Xi is affable and earnest, which adds strength to us overseas Chinese who start businesses in foreign countries. The Belt and Road Initiative proposed by President Xi has paved the way for boosting the world economy. Many countries in Europe and Asia have actively responded to the "Belt and Road Initiative" and set off a new round of "China fever" from the official to the private sector, and the friendly and cooperative relations with China have rapidly warmed up.

　　As a post-1970s generation, I witnessed the great changes in China from weak to strong and from poor to rich after the reform and opening up. As an old overseas Chinese who has been wandering overseas for more than 20 years, I personally feel the great glory that China’s prosperity has brought to overseas travelers. On the occasion of the Spring Festival, I sincerely wish China prosperity and the people of all ethnic groups in China happiness and well-being!

　　— — Jin Dongrong, President of Serbian Federation of Chinese and Overseas Chinese Associations

　　America — —

　　Chinese civilization has set an example for the world.

　　At the beginning of the new year, Vientiane is renewed. At this festive moment, I would like to extend my New Year greetings to the people of the whole country and wish my relatives in my hometown happiness, good health and well-being! China’s 5,000-year-old civilization and rapid development achievements in recent decades have set an example for the world. President Xi’s initiative to build a community of human destiny is worth pondering by the world.

　　China and the United States are the most influential and appealing countries in the world, and they have unshirkable responsibilities and responsibilities for international affairs and human welfare. Overseas Chinese in the United States all hope that China and the United States can live in peace and respect each other and jointly shoulder the important mission of world peace and development.

　　— — Liu Ziyang, American Overseas Chinese and Vice President of the US-China Guangdong Chamber of Commerce.

　　The past year was a year in which the Chinese nation made great efforts to realize the Chinese dream. Under the leadership of the CPC Central Committee with the Supreme Leader at the core, the people of China have made great efforts to tackle problems and made brilliant achievements in various fields, and overseas Chinese are extremely proud of this.

　　President Xi’s recent speech at the annual meeting of the Davos Forum was extremely inspiring! After listening to President Xi’s speech, I said to my friend: I feel proud to be Chinese again! The golden rooster will bring good news, more exciting news and more abundant harvest will come in the Year of the Rooster. Let’s meet the wonderful time with all our energy!

　　— — Zhao Bingchi, President of Canadian Canadian Canadian China Unification Promotion Association and President of Ottawa Chinese Federation.

　　2016 is a leap year for China and Canada. Within a month, the two prime ministers exchanged visits, which opened a new chapter in Sino-Canadian relations. Our overseas Chinese in Canada are delighted with this. In 2016, parliament of canada recognized the Lunar New Year as a Canadian holiday, and we were excited about it from the first day of the lunar calendar to the fifteenth day of the lunar calendar.

　　I went to Shenzhen in 1979 to explore and witnessed the development of China. After 28 years in Canada, I witnessed the deepening of trade and economic relations between China and Canada, and also witnessed the contribution and development of overseas Chinese in Canada. I wish the people of the whole country a happy New Year and a continuous improvement in their living standards!

　　— — Lu Hongmin, Executive Chairman of Ottawa Federation of Chinese Associations

　　I have lived in Brazil for many years and witnessed the development of China-Pakistan friendship. After the reform and opening up, earth-shaking changes have taken place in China. Chairman of the Supreme Leader proposed the Belt and Road Initiative, so that more countries can benefit from China’s economic development.

　　As a Chinese, I have gained more respect overseas and feel very proud. Only when the country is rich can the people be strong. Thanks to the support provided by the powerful China for overseas Chinese, we will definitely make our own contribution to promoting cooperation and exchanges between China and the local area.

　　— — Yin Chuping, President of Brazil China Peaceful Reunification Promotion Association

　　Oceania — —

　　Vigorously carry forward the hardworking, brave, peaceful and friendly spirit of the Chinese nation.

　　During his visit to Australia in 2014, the Chairman of the Supreme Leader told overseas Chinese that China and Australia should give full play to their complementary economic advantages and deepen economic and trade cooperation. Today, the China-Australia FTA has been formally implemented for more than a year, and the trade between China and Australia has grown steadily, and the cooperation between the two countries in the fields of economic and trade exchanges and cultural exchanges has become closer.

　　The Spring Festival is an important festival of the Chinese nation, which embodies the virtues of attaching importance to family, affection and friends in China traditional culture. The vast number of overseas Chinese in Australia have vigorously promoted the excellent Chinese culture and traditions, as well as the hardworking, brave, peaceful and friendly spirit of the Chinese nation, which has won wide recognition and respect from Australian society and made outstanding contributions to the construction, development and prosperity of Australia.

　　On the occasion of the arrival of the Spring Festival, I wish my compatriots around the world good luck and all the best in the Spring Festival!

　　— — Huang Xiangmo, President of Australia China Peaceful Reunification Promotion Association

　　(Newspaper Bangkok, Cairo, Johannesburg, Moscow, Berlin, Brussels, new york, Ottawa, Rio de Janeiro and Canberra, January 27th, by reporters Zhang Zhiwen, Wang Yunsong, Li Zhiwei, Qu Song, Guan Kejiang, Ren Yan, Li Bingxin, Wu Yun, Wang Hailin and Bao Jie)

Notice of the General Office of the People’s Government of Henan Province on printing and distributing some policies and measures to support enterprises to stabilize their posts and stabilize producti

Municipal People’s governments under the jurisdiction of all provinces, Jiyuan Demonstration Zone, Airport Management Committee, and various departments of the provincial people’s government:

　　"Several policies and measures to support enterprises to stabilize posts and stabilize production before and after the Spring Festival" have been approved by the provincial government and are hereby printed and distributed to you, please implement them carefully.

　　General Office of Henan Provincial People’s Government

　　January 14th, 2023

Some policies and measures to support enterprises to stabilize their posts and stabilize production before and after the Spring Festival

　　In order to thoroughly implement the spirit of the provincial economic work conference, implement the deployment of the eighth plenary session of the provincial government, encourage and guide enterprises to stabilize production and quickly resume production before and after the Spring Festival, continue to set off the upsurge of ensuring health and fighting for the economy in the whole province, minimize the impact of festivals on economic operation, sprint at the beginning and accelerate at the beginning, and promote the overall improvement of economic operation, the following policies and measures are formulated.

　　1. For industrial enterprises above designated size that are producing at full capacity in the first quarter of 2023, a financial reward of 100,000 yuan will be given. In the first quarter of 2023, industrial enterprises above designated size will be given a financial reward of 200,000 yuan, which will produce at full capacity and achieve a year-on-year increase in operating income of more than 10%. The bonus funds shall be shared by the provincial and local governments according to the ratio of 1: 1. (Responsible unit: Provincial Department of Finance, Department of Industry and Information Technology)

　　2. Support enterprises to continuously produce and use electricity at off-peak hours, and implement phased electricity consumption concessions for industrial enterprises that implement time-of-use tariffs. From January 17, 2023 to February 5, 2023 (20 days from the 26th day of the twelfth lunar month to the 15th day of the first lunar month), the flat electricity consumption of relevant enterprises shall be settled at 80% of the household electricity tariff, and the valley electricity consumption shall be settled at the current electricity tariff. (Responsible unit: Provincial Development and Reform Commission, electric power company)

　　3. Industrial enterprises above designated size that have maintained continuous production (the average daily electricity consumption is not less than 70% of the average daily electricity consumption in 2022) during the period from January 17, 2023 to February 5, 2023 (20 days in total from the 26th of the twelfth lunar month to the 15th of the first lunar month) will be awarded compensation according to the standard of 500 yuan per person, with the maximum amount of compensation for each enterprise not exceeding 10. (Responsible units: Provincial Department of Human Resources and Social Security, Department of Finance, Department of Industry and Information Technology, Statistics Bureau, Electric Power Company)

　　4. During the period from January 17, 2023 to February 5, 2023 (20 days in total from the 26th of the twelfth lunar month to the 15th of the first lunar month), 20% discount will be given to the expressway tolls of the "four guarantees" white-listed enterprises in the province. (Responsible unit: Provincial Department of Transportation, Development and Reform Commission, Finance Department)

　　5. According to the actual operation of the local economy, all localities should take measures such as issuing "red envelopes for staying at work", giving "warm-hearted New Year’s Eve", issuing exclusive coupons for people who have not returned home, and opening entertainment venues free of charge, so as to keep jobs at work, pay jobs, and leave jobs with affection to ensure the stable production of key enterprises to the maximum extent. (Responsible units: municipal governments under the jurisdiction of provinces, Jiyuan Demonstration Zone, Airport Area Management Committee)

　　6. All localities should strengthen the overall dispatch of epidemic prevention materials, smooth the logistics channels of medical materials, set up drug delivery points in advanced manufacturing development zones, support enterprises to strengthen the reserves of relevant drugs, masks and other epidemic prevention materials, and ensure the normal epidemic prevention needs before and after the Spring Festival and the medical treatment of frontline personnel. (Responsible units: municipal governments under the jurisdiction of provinces, Jiyuan Demonstration Zone, Airport Area Management Committee)

　　Relevant departments directly under the provincial government should refine the detailed rules for policy implementation as soon as possible, strengthen policy publicity and interpretation, strengthen business guidance, track and dispatch, and actively promote the implementation of various policies. All localities should combine local conditions to refine policies and measures, improve working mechanisms, and jointly promote the implementation of policies and measures.

Huang Yiqing was asked to be arrested： as a shareholder of four companies, he was arrested for rumors.

　　Zhongxin Jingwei Client August 28th On the 28th, Hongkou Branch of Shanghai Public Security Bureau informed that Huang Yiqing had been arrested for drug trafficking and drug abuse. Earlier, Yi Huang Qing once said that Shanghai Economic Investigation Police acted as Zhou Libo’s "protective umbrella" and was punished by administrative detention, but later admitted that it was a fabrication.

　　Hongkou Branch of Shanghai Public Security Bureau reported that Huang Yiqing, male, aged 34, was the ex-husband of actor Crystal. After being punished by the public security organs according to law for spreading false statements on the Internet, he continued to publish false statements through the Internet, and his behavior was suspected of causing trouble. On August 3, Hongkou Public Security Bureau criminally detained Huang according to law. After further investigation, the public security organs found that there were still illegal and criminal acts of selling and taking drugs to others in Yi Huang.

　　According to the data of Tianyancha, Huang Yiqing is a shareholder in four companies, of which one catering management company has been revoked, one industry and trade company has been cancelled, and the other two are in a state of existence, namely Shanghai Xindongli Super Run Automobile Club Co., Ltd. and Shanghai Jiajia Investment Management Co., Ltd.

　　Sky eye check screenshot

　　Among them, Huang Yiqing works as a supervisor in Shanghai Xindongli Super Run Automobile Club Co., Ltd., with an investment ratio of 70%, and works as an executive director and general manager in Shanghai Jiajia Investment Management Co., Ltd. with an investment ratio of 50%. The ultimate beneficiaries of both companies are Yi Huang Qing himself.

　　Sky eye check screenshot

　　It is worth noting that Shanghai Yujia Catering Management Co., Ltd., of which Huang Yiqing is a shareholder, was twice listed in the list of abnormal business operations because it failed to submit the annual report information as required; And on October 17, 2016, he was administratively punished by Shanghai Fengxian District Market Supervision Administration for self-suspension for six consecutive months. (Zhongxin Jingwei APP)

Consumption before the holiday ｜ Shantou, Guangdong： Sales volume tripled before the Spring Festival. Beef ball processing factory was busy with orders.

CCTV News:Our reporter learned in the interview that before the Spring Festival, the factory is the busiest time of the year. There are still ten days before the Spring Festival. What about the production and sales in chaoshan beef meatball?

Near the evening, the reporter saw at the entrance of this beef shop in Shantou that there was an endless stream of citizens who came to buy beef and beef balls, many of whom bought the goods of the year and sent them to relatives and friends.

The person in charge of the beef shop said that in the twelfth lunar month, business is getting better every day, and the current sales volume is three times that of usual. Chaoshan people eat cattle for freshness, so they have to work overtime to sell beef during the Spring Festival, and in order to ensure the stable supply during the Spring Festival, they have already paid the deposit to the slaughterhouse in advance.

Affected by the epidemic, large-scale catering parties have been reduced, and the purchase of beef balls by restaurants has decreased. At the same time, the terminal retail and family consumption of beef balls have increased significantly.

Beijing’s second ring road exit adds a solid line probe to treat ＂unruly＂!

Cctv newsThe Second Ring Road in Beijing is a road with a very large traffic volume, but individual drivers are unwilling to queue at the exit of the ring road for their own convenience, and continue to merge, forcibly merge or even jam. Recently, the traffic control department of Beijing has made "articles" on several exits of the main road of the Second Ring Road, aiming at those unruly drivers.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauNow we are at Fuchengmen Bridge. The south exit of Fuchengmen Bridge is the most important exit from the north to Financial Street. Many cars merge from the middle lane or the innermost lane to the exit, which directly affects the traffic of the whole West Second Ring Road. Every morning rush hour is affected by this exit, and vehicles can queue up all the way to Xizhimen Bridge.

In order to standardize the traffic order at the entrance and exit sections of the Second Ring Road, as well as the auxiliary roads along the route, and solve the outstanding problems of congestion and vehicle queue-jumping at the exit sections of the Second Ring Road, the Beijing Traffic Control Department has made overall planning and transformation of the relevant exit sections, and customized specific transformation plans according to the road conditions of each exit. By improving the exit warning signs, adding snapshot monitoring equipment, drawing solid lanes, removing isolation barriers and other measures, the exit traffic order is standardized and traffic congestion is alleviated.

Li Lei, a policeman from the Order Department of Beijing Public Security Traffic Management BureauThe inner two lanes are marked with solid lane lines that prohibit merging, so as to reduce the interweaving of vehicles. Vehicles that need to go to Financial Street are merged from Fuchengmen Bridge North to the outer lane in advance to ensure the normal driving of the inner two lanes, thus improving the overall traffic of our West Second Ring Road.

According to statistics, up to now, the traffic control department of Beijing has drawn solid exit lines and lane lines at seven exits, such as the high-speed exit of the outer ring airport of the Second Ring Road, the exit of Xiwai Street and the south exit of Fuchengmen Bridge, and three exits, such as the north exit of Fuxingmen Bridge, the high-speed exit of the airport and the south exit of Jianguomen Bridge, in the inner ring road of the Second Ring Road, which has improved the warning signs. In view of the problem of traffic jam at the exit, some illegal monitoring devices are installed on the basis of the comprehensive utilization of the original monitoring equipment, and the two straight lanes inside are guaranteed not to be affected by the exit section by standardizing the vehicle driving path. The police suggested that the driver should pay attention to the change of the marking line of the exit sign of the loop and plan the route in advance.

Analysis and Prospect of Global Pharmaceutical Market in 2017-2022

I. Market size and growth rate

the year 2017The global prescription drug market size is$774 billion, estimated from 2017 to 2022.The annual growth rate of CAGR is 6.5%By 2022, the prescription drug market will exceed the trillion-dollar level for the first time, reaching$1.06 trillion. CAGR exceeds that in the field of instruments5.1%.

Prescription drug market is divided intoPrescription drugs (except generic drugs and Orphan drugs), generic drugs and orphan drugs.Three market segments. Among them,generic drugsIn 2017-2022, the scale of the overall prescription drug market will be10%-11%The annual growth rate of CAGR is slightly lower than that of the overall prescription drug market.6.0%The market scale will be from 2017.$84 billionGrowing to 2022$112 billion; Annual growth rate of orphan drugs in 2017-2022CAGR was 11.2%, a rare double-digit growth, the market size will be from 2017.$123 billionrise to$209 billion, accounting for the overall prescription drug market size will be from15.9% in 2017rise to19.7% in 2022.

Although the expected market share can be increased, in fact, the proportion will remain basically unchanged in the next five years; The proportion of orphan drugs has steadily increased.

2. What is the impact of the patent cliff?

It is expected to be from 2017 to 2022.$194 billionThe drug market is facingPatent cliff patent cliffThe challenge is mainly due toBiosimilar, a biosimilarIn the previous article, I also shared the market of Biosimilar, the global biosimilar market and competition analysis |Q said. This patent cliff may be fromThe first patent cliff in 2012After the second patent cliff peak.

Of course, there are still some variables in the future who will eat this big cake in the generic drug market. In addition to companies that focus on generic drugs,Big pharmaceutical companiesNow I have also found a way. If my patented drug expires, I can authorize it to be authorized generics, which is exactly the same as the original patented drug, except that the trademark is removed and the price is lower, and the regulatory authorities do not have to work hard to approve it. Regarding the definition of Authorized Generics, FDA gives the following explanation.

The term “authorized generic” drug is most commonly used to describe an　approved brand name drug that is marketed without the brand name on its label. Other than the fact that it does not have the brand name on its label, it is the　exact same drug product as the branded product.An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. In some cases, even though it is the same as the brand name product, a company may choose to sell the authorized generic　at a lower cost　than the brand name drug.

Many big pharmaceutical companies have begun to plan this.Instead of letting others eat the cake, it is better to distribute it yourself or share it with others.; The time and method of specific sales are also controllable; Why not?

III. What are the hot treatment areas?　

fromFrom the perspective of Biotech, a biological medicine, and Conventional medicine, Conventionality.Look, 2017-2022Biological medicineThe proportion of the overall market has steadily increased and tends to be flat, and will be from26% in 2017 increased to 30% in 2022.; At the same time, biopharmaceutical head productsTop 100 productsThe proportion of total biopharmaceuticals is from 2016.49%Increased to 202252%.

fromTreatment areaLooking at it, the following ten areas have the largest market scale.

（1）Oncology of tumorIt is still the largest market segment, with CAGR in 2016-2022.12.7%Will reach in 2022.$192.2 billionSales, accounting for global market share17.5%.

（2）Diabetes Anti-diabeticsIt is the second largest market segment, with CAGR in 2016-2022.4.8%Will reach in 2022.$57.9 billionSales, accounting for global market share5.3%.

（3）Rheumatism Anti-rheumaticsIt is the third largest market segment, with CAGR in 2016-2022.0.6%Will reach in 2022.$55.4 billionSales, accounting for global market share5.0%.

（4）be antiviralAnti-virusIt is the fourth largest market segment, with CAGR in 2016-2022.-2.1%Will reach in 2022.428Billion dollarsSales, accounting for global market share3.9%. fornegative growthSo Gilead is nervous.

（5）Vaccine VaccinesIt is the fifth largest market segment, with CAGR in 2016-2022.4.2%Will reach in 2022.353Billion dollarsSales, accounting for global market share3.2%.

（6）Bronchodilators of respiratory system bronchusIt is the sixth largest market segment, with CAGR in 2016-2022.1.0%Will reach in 2022.301Billion dollarsSales, accounting for global market share2.7%.

（7）Sensory organsIt is the seventh largest market segment, with CAGR in 2016-2022.five.8%Will reach in 2022.283Billion dollarsSales, accounting for global market share2.6%.

（8）Immunosuppressant ImmunosuppresantsIt is the eighth largest market segment, and the CAGR in 2016-2022 is14.6%Will reach in 2022.263Billion dollarsSales, accounting for global market share2.4%. This field is one of all fields.The fastest growth rateYes.

(9) Hypertension Anti-hypertensives is the ninth largest market segment, and the CAGR in 2016-2022 is-0.2%Will reach in 2022.244Billion dollarsSales, accounting for global market share2.2%.

（10）Cardiovascular Anti-coagulantsIt is the tenth largest market segment, and the CAGR in 2016-2022 iseight.6%Will reach in 2022.232Billion dollarsSales, accounting for global market share2.1%.

By 2022,Top Five Top5 Tumor DrugsWill beCelgeneThe company’s immunomodulatorRevlimid、BMScorporatePD1 antibody Opdivo, Merck’sPD1 antibody Keytruda、AbbViecorporateBTK inhibitor Imbruvica、PfizercorporateCDK inhibitor Ibrance. The next five years will bePD1The overbearing world adds up to the tumor market.10%.

4. How much does it cost to develop new drugs?

First of all, the big pharmaceutical companiesAt present, R&D investment has accounted for about 20% of the sales revenue ratio.. Without research and development, there will be no new products, and cruel competition will push you out of the market.

Secondly,On average, each new drug NME(New Molecular Entity) costs $5 billion.. $5 billion is definitely not a small figure, which exceeds the previous cost.

Furthermore, according to the sales in the United States after the approval of the new drug,The annual sales of each NME in the fifth year is about $522 million.. According to the current Hacth-waxman Act, the new drug NME has5 years of data exclusivityandThree years of market exclusivity,　After that, generic drugs went on the market. It is necessary for pharmaceutical companies to expand indications, conduct more research and development, or cooperate in research and development as soon as possible.

5. Who are the top ten pharmaceutical companies?

First place,Novartis NovartisIn 2016-2022, CAGR is3%, sales reached in 2022.49.8 billion dollars, accounting for market share4.7%.

Second place,Pfizer PfizerIn 2016-2022, CAGR is1%, sales reached in 2022.49.7 billion dollars, accounting for market share4.7%.

Third place,Roche RocheIn 2016-2022, CAGR is4%, sales reached in 2022.$49.6 billion, accounting for market share4.7%.

Fourth place,Sanofi sanofiIn 2016-2022, CAGR is3%, sales reached in 2022.$41.7 billion, accounting for market share3.9%.

Fifth place,Johnson&JohnsonIn 2016-2022, CAGR is4%, sales reached in 2022.$40.5 billion, accounting for market share3.8%.

Sixth place,Merck&CoIn 2016-2022, CAGR is1%, sales reached in 2022.$38.5 billion, accounting for market share3.6%.

Seventh place,AbbVie in AbbwayIn 2016-2022, CAGR is5%, sales reached in 2022.$34 billion, accounting for market share3.2%.

Eighth place,GlaxoSmithKlineIn 2016-2022, CAGR is3%, sales reached in 2022.$33.7 billion, accounting for market share3.2%.

Ninth place,AstraZeneca AstraZenecaIn 2016-2022, CAGR is5%, sales reached in 2022.$28.4 billion, accounting for market share2.7%.

Tenth place,Xinji pharmaceutical CelgeneIn 2016-2022, CAGR is15%, sales reached in 2022.$26 billion, accounting for market share2.5%.

It can be seen that the top three are very tight, and the rankings have not changed much. Pfizer has retreated to the second place, Novartis has jumped to the first place, and Roche is still firmly in the third place.

Gilead fell out of the top ten.

Celgene jumped 11 places into the top ten.

This article was originally published on WeChat WeChat official account’s "Investment and Life of the Owner of Q Village".

Strictly crack down on illegal registration of real estate! Ministry of Natural Resources： Strictly prevent the legalization of small property houses.

　　CCTV News:At present, the real estate registration system has been fully operated in the whole country. During a period of operation, there are some difficulties in obtaining certificates in real estate registration in some places. Recently, the Ministry of Natural Resources has deployed a special rectification of the style of the real estate registration window throughout the country.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of the unified registration system for real estate, there have been 109 halls in China, and there have been problems of queuing in the early morning and scalpers changing their numbers. Some places have turned a blind eye to the gap between the service ability and level and the people’s demand for permits, and have not taken the initiative to solve it in time, which is simply limited."

　　The rectification deployment focuses on the style of real estate registration window, such as "pushing around and dragging" and "difficulty in obtaining a certificate". It will take three months to comprehensively promote the "reduction of certificates and convenience for the people" nationwide, and clean up and cancel the pre-existing links without legal and regulatory basis. At the same time, it is necessary to comprehensively clean up all kinds of unnecessary certificates such as "wonderful" certificates, circular certificates and repeated certificates that bother enterprises and the masses.

　　Wang Guanghua, Vice Minister of Natural Resources: "Those materials that can be obtained through the Internet shall not be submitted repeatedly by the masses. Then in fact, the information that can be obtained through information sharing between government departments is fast, accurate and reliable, so it is beneficial to improve efficiency and ensure quality. "

　　In terms of establishing a standardized service system in an all-round way, the Ministry of Natural Resources said that all localities should classify and establish standardized and simplified standardized business processes to provide clear guidance for the masses to do things.

　　Wang Guanghua, Vice Minister of Natural Resources: "There is no pre-position for real estate registration. As long as the application materials submitted by the applicant meet the requirements of the provisional regulations on real estate registration and the detailed rules for the implementation of the provisional regulations on real estate registration, the real estate registration agency should handle it, and the sharing and collaboration between departments should be placed in the window. Don’t let the people run back and forth."

　　Issues left over from history should not be shelved for a long time.

　　According to the Ministry of Natural Resources, for the multi-sector decentralized registration period before the implementation of unified registration of real estate, historical problems caused by imperfect and irregular management links should not be shelved for a long time.

　　Wang Guanghua, Vice Minister of Natural Resources: "At present, there are still more than 4.8 million pieces in the country, and the problems left over from the history of decentralized registration have not been solved. In some places, in the face of the outbreak of historical problems, they did not organize forces to focus on investigation and coordination, and directly let the window staff respond, simply because the procedures were incomplete and they could not be handled."

　　According to the Ministry of Natural Resources, all localities should actively discuss and study the problems left over from history with planning, housing construction and other departments, and report to the people’s governments of cities and counties to issue policies to solve them in time to meet the people’s normal demand for accreditation.

　　Strictly investigate violations of laws and regulations for real estate registration　

　　In addition, the Ministry of Natural Resources also emphasized that it is necessary to prevent "small property houses" from being legalized through real estate registration. At the same time, it is necessary to crack down on the abuse of power to forge false registration of materials, deliberately misregister, illegally register for financing, maliciously collude with illegal registration and disclose registration information.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of real estate registration, a total of 303 cases of illegal registration have been found throughout the country. In recent years, the state land supervision agency found that some places illegally and falsely registered mortgages for public welfare roads, parks, public facilities and other land for financing needs, and some places maliciously colluded with third parties to register illegally and leaked registration information."

National Health Commission： Strengthen the coordinated development of medical insurance and medicine

At the press conference held by the National Health and Wellness Committee on February 28th on the progress and effectiveness of health and wellness, Mi Feng, spokesperson of the Committee and deputy director of the Propaganda Department, introduced that the main health indicators of Chinese residents are currently in the forefront of middle-and high-income countries.

Continuously meet the health service needs of the people.

Zhuang Ning, deputy director of the Department of Physical Reform of the National Health and Wellness Commission, said that in recent years, the National Health and Wellness Commission has actively played a leading and coordinating role in medical reform and strengthened the coordinated development of medical care, medical insurance and medicine with relevant departments.

Zhuang Ning introduced that in terms of medical care, through the layout and construction of national medical centers, national regional medical centers, and provincial regional medical centers, we will strengthen relevant clinical key specialties and solve the problem of people seeking medical treatment across regions. According to statistics, in the first four batches of 76 national regional medical centers, more than 460 specialties have been built and more than 6,200 new medical technologies have been developed, and the average number of patients transferred to hospitals has dropped by about 30% compared with that before construction. The rate of common and frequently-occurring diseases in the county is over 90%.

Public hospitals are the main body of China’s medical service system. According to Jiao Yahui, director of the Department of Medical Administration of the National Health and Wellness Commission, there are 2,817 tertiary public hospitals and 5,384 secondary public hospitals participating in the performance appraisal of public hospitals nationwide. According to the data of the past five years, the development mode, operation mode and resource allocation of tertiary public hospitals in China are more reasonable. The two indexes reflecting the technical difficulty of medical services, namely, the case combination index and the proportion of discharged patients in Grade IV surgery, have increased by 10% and 23.5% respectively, and the application level of electronic medical records in 83% tertiary public hospitals has reached Grade IV or above. The number and proportion of doctors in short supply such as anesthesiology, pediatrics, and severe diseases in tertiary public hospitals across the country have increased, constantly meeting the needs of people’s health services.

Zhuang Ning said that in terms of medical insurance, China has further improved the universal medical insurance system, raised the per capita financial subsidy standard for residents’ medical insurance to 640 yuan, and continuously improved the level of general outpatient medical insurance for employees. In medicine, we will further expand the breadth and depth of centralized procurement of pharmaceutical consumables and further reduce the inflated price. Revise and improve the medical insurance drug list, improve the basic drug system, speed up the registration and listing of urgently needed drugs, children’s drugs and innovative medical devices, and strive to meet the people’s drug demand.

Continuously improve the ability of disease prevention and control

In recent years, China has continuously improved the multi-sectoral cooperation mechanism to enhance the ability of disease prevention and control. Qin Xingqiang, deputy director of the Comprehensive Department of the National Bureau of Disease Control and Prevention, said that the laws, regulations and policy systems related to the emergency response of infectious diseases in China have been continuously improved, and the emergency management system and mechanism have been continuously optimized, basically forming an emergency plan for public health emergencies, covering multiple diseases and covering national, provincial, municipal and county levels. Relying on the national and provincial centers for disease control and prevention, 20 national teams for the prevention and control of sudden acute infectious diseases have been set up, covering 17 provinces.

According to reports, since the "14 th Five-Year Plan", the central budget has allocated a total of 13.1 billion yuan to support the construction of disease control systems at the national, provincial, municipal and county levels. In 2023, the central government allocated 17.687 billion yuan for disease control projects through transfer payment for the prevention and control of major infectious diseases and endemic diseases.

Qin Xingqiang said that at present, the average reporting time of China’s infectious disease network direct reporting system has been shortened from five days to four hours now. At the national level, a technical system for rapid identification of 300 pathogens within 72 hours has been established, and 100% of provincial and 90% of municipal CDC have the ability to detect nucleic acids and isolate viruses. In the prevention and control of major infectious diseases, the rapid rise of AIDS epidemic in key areas has been effectively curbed; The mortality rate of tuberculosis remains at a low level; All endemic counties of schistosomiasis have reached the state of transmission interruption; Measles, Japanese encephalitis and other vaccines can prevent the incidence of infectious diseases from falling to the lowest level in history.

Construction of 321 high-level key disciplines of traditional Chinese medicine

In order to promote the development of China’s traditional Chinese medicine service system, Ouyang Bo, deputy director of the Comprehensive Department of the State Administration of Traditional Chinese Medicine, introduced that the State Administration of Traditional Chinese Medicine, the National Health and Wellness Commission and the National Development and Reform Commission took the lead in establishing an inter-departmental working mechanism with relevant departments, and the central government invested nearly 13 billion yuan to promote key tasks and major engineering projects to basically achieve "double half".

Ouyang Bo said that China’s traditional Chinese medicine inheritance and innovation has been steadily promoted-46 national traditional Chinese medicine inheritance and innovation centers have been built, and 50 superior diseases treated by traditional Chinese medicine, 52 integrated Chinese and Western medicine diagnosis and treatment programs, 100 appropriate technologies and 100 Chinese medicine varieties with unique curative effects have been selected and released. The official publication of the first batch of 74 books in the "Chinese Medical Collection" marks a major stage achievement in the compilation of ancient Chinese medicine books.

At the same time, the team of talents with Chinese medicine characteristics has been growing, training 50 Qihuang scholars, 500 national outstanding clinical talents of Chinese medicine, 100 young Qihuang scholars, 35 innovative teams of Chinese medicine, and building 321 high-level key disciplines of Chinese medicine.

According to preliminary estimates, in 2023, the total number of medical treatment in Chinese medical and health institutions was 1.28 billion, and the number of discharged patients was 41.486 million. Chinese medicine played an active role in serving people’s health.

Building a high-quality and efficient Chinese medicine service system is one of the main tasks of the development plan of Chinese medicine in the 14 th Five-Year Plan. In this regard, Ouyang Bo said that the State Administration of Traditional Chinese Medicine aims to achieve high-quality Chinese medicine services for everyone nearby, promote 14 Chinese medicine hospitals to be included in the founding unit of the National Medical Center, lay out and build 27 national regional medical centers for Chinese medicine, and continue to promote the construction of 62 "flagship" hospitals and 138 key hospitals with Chinese medicine characteristics. At the same time, optimize the supply of Chinese medicine services, select about 1,000 national traditional Chinese medicine specialties and 500 "flagship" departments for the coordination of Chinese and Western medicine, determine 31 units for the construction of Chinese medicine rehabilitation centers, strengthen the construction of pediatrics and geriatrics departments in Chinese medicine hospitals, and promote the construction of outpatient clinics for Chinese medicine specialties; Taking the construction of county-level Chinese medicine hospitals as the leader, we will build a solid grassroots network, promote tertiary hospitals to help 699 county-level Chinese medicine hospitals, and achieve full coverage of grassroots Chinese medicine museums in 23 provinces, so as to facilitate the masses to take a good look at Chinese medicine at their doorsteps.(Reporter Jin Zhenya)

Korean media： Former South Korean President Lee Myung-bak, who is serving his sentence, is hospitalized outside the prison due to illness.

　　[Global Network Report] Yonhap News Agency reported that according to the news of the Korean Ministry of Justice on the 17th, former President Lee Myung-bak, who was detained in Anyang Prison in Gyeonggi Province, was admitted to Seoul National University Hospital the day before for a disease check-up, and the time of hospitalization, discharge and escort was inconvenient to disclose due to security problems.

Profile photo: Li Mingbo was transferred to Anyang Prison. Image source: Yonhap News Agency

　　The Korean Ministry of Justice said that Lee Myung-bak will be examined according to the opinions of the hospital during his hospitalization. According to the report, Lee Myung-bak was treated for diabetes and other diseases, and he was treated outside prison for three times last year. According to reports, Lee Myung-bak was sentenced to 17 years in prison for corruption and bribery, fined 13 billion won (about 69.24 million yuan), and pursued 5.78 billion won in criminal proceeds.

　　It is worth mentioning that another former South Korean President, park geun-hye, was released from prison by amnesty at the end of December, 2021. Her lawyer, Liu Rongxia, said on the 16th that park geun-hye was in better health and would speak to the people when she left the hospital. Liu Rongxia also relayed that park geun-hye was sad that another former president, Lee Myung-bak, was not granted amnesty.

Hualong No.1 demonstration project completed in an all-round way ｜ China’s advanced nuclear power has achieved a technological breakthrough in the whole industry chain, and the reliability of Hualong

　　CCTV News:It is understood that Fuqing Nuclear Power Unit 5, the first Hualong No.1 unit in China, has been put into commercial operation for more than a year, and its power generation has exceeded 7 billion kWh. At present, the first refueling work has been successfully completed, which has fully verified the reliability of Hualong No.1 technology.

　　As the world’s first Hualong No.1 unit, Fuqing Nuclear Power Unit 5 has just completed its first refueling overhaul. In order to ensure the long-term safe and reliable operation of nuclear power units, nuclear power units need to replace nuclear fuel regularly, and during this period, important equipment should be inspected and maintained. This work is called overhaul. At present, the unit has completed the loading of nuclear fuel components and is about to start the second start.

　　The world’s first reactor, Hualong No.1, was officially put into commercial operation on January 30, 2021, which achieved a technological breakthrough in the whole industrial chain of independent design, manufacture, construction and operation of China’s advanced nuclear power. After running for more than a year, it has been running smoothly and normally, without unplanned shutdown, which fully verified the reliability of Hualong technology.

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