标签归档 西安耍耍

Municipal People’s governments under the jurisdiction of all provinces, Jiyuan Demonstration Zone, Airport Management Committee, and various departments of the provincial people’s government:

　　"Several policies and measures to support enterprises to stabilize posts and stabilize production before and after the Spring Festival" have been approved by the provincial government and are hereby printed and distributed to you, please implement them carefully.

　　General Office of Henan Provincial People’s Government

　　January 14th, 2023

Some policies and measures to support enterprises to stabilize their posts and stabilize production before and after the Spring Festival

　　In order to thoroughly implement the spirit of the provincial economic work conference, implement the deployment of the eighth plenary session of the provincial government, encourage and guide enterprises to stabilize production and quickly resume production before and after the Spring Festival, continue to set off the upsurge of ensuring health and fighting for the economy in the whole province, minimize the impact of festivals on economic operation, sprint at the beginning and accelerate at the beginning, and promote the overall improvement of economic operation, the following policies and measures are formulated.

　　1. For industrial enterprises above designated size that are producing at full capacity in the first quarter of 2023, a financial reward of 100,000 yuan will be given. In the first quarter of 2023, industrial enterprises above designated size will be given a financial reward of 200,000 yuan, which will produce at full capacity and achieve a year-on-year increase in operating income of more than 10%. The bonus funds shall be shared by the provincial and local governments according to the ratio of 1: 1. (Responsible unit: Provincial Department of Finance, Department of Industry and Information Technology)

　　2. Support enterprises to continuously produce and use electricity at off-peak hours, and implement phased electricity consumption concessions for industrial enterprises that implement time-of-use tariffs. From January 17, 2023 to February 5, 2023 (20 days from the 26th day of the twelfth lunar month to the 15th day of the first lunar month), the flat electricity consumption of relevant enterprises shall be settled at 80% of the household electricity tariff, and the valley electricity consumption shall be settled at the current electricity tariff. (Responsible unit: Provincial Development and Reform Commission, electric power company)

　　3. Industrial enterprises above designated size that have maintained continuous production (the average daily electricity consumption is not less than 70% of the average daily electricity consumption in 2022) during the period from January 17, 2023 to February 5, 2023 (20 days in total from the 26th of the twelfth lunar month to the 15th of the first lunar month) will be awarded compensation according to the standard of 500 yuan per person, with the maximum amount of compensation for each enterprise not exceeding 10. (Responsible units: Provincial Department of Human Resources and Social Security, Department of Finance, Department of Industry and Information Technology, Statistics Bureau, Electric Power Company)

　　4. During the period from January 17, 2023 to February 5, 2023 (20 days in total from the 26th of the twelfth lunar month to the 15th of the first lunar month), 20% discount will be given to the expressway tolls of the "four guarantees" white-listed enterprises in the province. (Responsible unit: Provincial Department of Transportation, Development and Reform Commission, Finance Department)

　　5. According to the actual operation of the local economy, all localities should take measures such as issuing "red envelopes for staying at work", giving "warm-hearted New Year’s Eve", issuing exclusive coupons for people who have not returned home, and opening entertainment venues free of charge, so as to keep jobs at work, pay jobs, and leave jobs with affection to ensure the stable production of key enterprises to the maximum extent. (Responsible units: municipal governments under the jurisdiction of provinces, Jiyuan Demonstration Zone, Airport Area Management Committee)

　　6. All localities should strengthen the overall dispatch of epidemic prevention materials, smooth the logistics channels of medical materials, set up drug delivery points in advanced manufacturing development zones, support enterprises to strengthen the reserves of relevant drugs, masks and other epidemic prevention materials, and ensure the normal epidemic prevention needs before and after the Spring Festival and the medical treatment of frontline personnel. (Responsible units: municipal governments under the jurisdiction of provinces, Jiyuan Demonstration Zone, Airport Area Management Committee)

　　Relevant departments directly under the provincial government should refine the detailed rules for policy implementation as soon as possible, strengthen policy publicity and interpretation, strengthen business guidance, track and dispatch, and actively promote the implementation of various policies. All localities should combine local conditions to refine policies and measures, improve working mechanisms, and jointly promote the implementation of policies and measures.

　　general situation Wenzhou Daily Newspaper Group (hereinafter referred to as Wenbao Group) is a new modern mainstream media with Wenzhou Daily as the core newspaper, Wenzhou Evening News, Wenzhou Metropolis Daily, Wenzhou Business Daily, technology and finance Times, Wenzhou News Network, Wenzhou People’s Magazine and Europe-China United Times as six newspapers, one network and one publication. In 2019, Wenbao Group’s total revenue was 517 million yuan (including tax), including 132 million yuan from layout economy, accounting for 25.53% of the total revenue, 385 million yuan from off-page economy, accounting for 7.447% of the total revenue, and its profit increased by 4.74 million yuan year-on-year. In the 2019 news award selection, he won one first prize and two third prizes in the China City Party Newspaper Media Integration Award, ranking first in the China City Party Newspaper in terms of the number of awards; Won 3 national science and technology newspaper system excellent works awards, ranking among the best in the national science and technology newspaper; He won 28 Zhejiang News Awards, including 3 first prizes, accounting for about one-fifth of the total number of local newspapers in the province, ranking first in the provincial party newspaper group for the eighth consecutive year. The comprehensive strength and operation scale rank among the best in the national prefecture-level newspaper groups.

　　News propaganda　In 2019, Wenbao Group adhered to the correct direction of public opinion, and launched "70 years of Wenzhou Exhibition", "Do not forget your initiative mind, keep in mind the mission" and "Strive for 1161 and forge ahead in 2019" around such major themes as "70th anniversary of the founding of New China", "Construction of two districts", "Wenzhou Challenge Six Competitions" and "Three Helps and Three Reds". More than 28,200 reports were published, more than 3,600 positive reports were reprinted by People’s Daily, Xinhua News Agency, Zhejiang Daily and other media, and more than 13,500 reports were reprinted by today’s headlines, Netease, Tencent and other online media. 30 articles, such as Rereading the Letter from Martyr Liu Ying and Feeling the Power of "Pursuing Dreams", were promoted and spread by "Learning Power", and "China Private Enterprises" Focusing on 12 counties (cities, districts), 3 functional areas and more than 70 municipal departments in the city, 713 front-page manuscripts and 359 special editions were published in Wenzhou Daily, adding luster to the highlights of various localities and departments. Do a good job in typical propaganda, establish outstanding figures such as "Running Brother" Liu Wenzhong, "Hero Letter" Liu Ying, Yongjiashan village cadre Xu Wenhai, and enhance the image of "the most beautiful Wenzhou person". The number of clicks on the first zebra crossing "low-headed people" ticket in China was more than 300 million, which was reprinted and forwarded by 223 media such as People’s Daily, Xinhua News Agency and CCTV. "Hero’s Letter" has become a media explosion, and the total number of hits of the series of short videos exceeds 10 million.It has become an ideological and political course in Wenzhou University and more than 10 primary and secondary schools.

　　Center report　In 2019, Wenbao Group focused on the construction of "two districts", and undertook major conference activities such as the work conference organized by the All-China Federation of Industry and Commerce and the special press conference in Wenzhou to celebrate the 70th anniversary of the founding of New China, and launched more than 10 columns and special topics with over 12 million hits. Focusing on the "Wenzhou Challenge Six-Match Competition", more than 10 columns and special topics such as the county (city, district) industrial cluster conference and the "Wenzhou Challenge Six-Match Competition" municipal unit conference were launched, and more than 110 special editions were published, with more than 6.5 million hits. Focus on the special activities of "Three Helps and Three Reds", launch more than 10 columns, organize a large-scale interview activity of "Flying to Wenzhou Town Street", and publish more than 120 reports, creating a strong public opinion atmosphere for promoting the implementation of the special activities of "Three Helps and Three Reds".

　　management control　In 2019, Wenbao Group enhanced its development ability through business innovation, accelerated its deep integration with education, tourism, exhibitions and other fields, held 33 large-scale exhibitions such as the Cultural Fair, the Expo Creation Fair and the Car Fair, and undertook major conference activities such as the work conference organized by the National Federation of Industry and Commerce, the Wenzhou special press conference to celebrate the 70th anniversary of the founding of New China, and the online theme publicity of "Private Economy and High-quality Development in the New Era", achieving a revenue of 54.1 million yuan, and the Cultural Fair won the "Expo". Technology and finance Times was commended by the Ministry of Science and Technology in the major demonstration activities of the National Science and Technology Week in 2019. Europe and China United Times held the 2019 "Belt and Road" China Brand World Tour into Tajikistan. There are more than 6,640 kinds of goods on the shelves of the first batch of newspaper media e-commerce in China, with users exceeding 400,000 and accumulated turnover of 199.6 million yuan. It won the second batch of growing cultural enterprises in Zhejiang Province, the top 100 e-commerce enterprises in Zhejiang Province in 2018 and the special contribution award of e-commerce industry in Zhejiang Province, and was selected as the key cultural enterprise in Wenzhou in 2019-2020. The Tourism Media Center promoted the issuance of "Wenzhou Tourism Huimin Card", and deepened cooperation with 39 state-owned scenic spots (forest parks) and nearly 40 stores of more than 20 cooperative businesses, with a total card issuance of about 40,000 cards and a total revenue of more than 7 million yuan. The book publishing planning center has built a digital platform in southern Zhejiang and opened up the copyright market. In four months, it has accepted more than 5,200 pieces of copyright registration and issued more than 3,500 pieces of certificates.Copyright registration ranked third in the province. Relying on resource sharing, Wenzhou International Exhibition Co., Ltd. planned and integrated into the "2050 Earth Needs You" popular science exhibition, the Youth Science Association, the first world Wenzhou people’s asset allocation exhibition and other exhibitions, achieving a revenue of more than 5 million yuan. Seven projects, such as "instant delivery of warm newspaper+unmanned pre-warehouse" and Wenzhou Travel Huimin One Card, won the 6th Zhejiang Newspaper Innovation Project Award, ranking first in the provincial party newspaper group in terms of number and rank.

　　media convergence　In 2019, Wenbao Group complied with the new trend and development of media integration, promoted content production, technology application, platform presentation and public service sharing, and built "four all" media, and its series of innovative practices were at the forefront of the whole province. Accelerate the construction of "Central Kitchen" 3.0, build three media communication phalanxes: Party newspaper, city and finance, with more than 10 media forms such as "newspaper, network, magazine, micro-terminal and screen", and launch more than 20 50W+ new media platforms, such as Wenzhou News, Wenzhou Publishing, Palm Wenzhou and Internet Politics, gathering more than 18 million readers. Wenzhou Publishing, Wenzhou News APP and Wenzhou Daily New Media jointly built and shared the "Central Kitchen" to build the first government mobile communication platform in Wenzhou, with over 4 million users. Wenzhou News Client won the excellent media platform of the national party newspaper. Established strategic cooperation with Zhejiang Newspaper Group, mainly in Wenzhou, built characteristic county-level media integration centers in Longwan and Ouhai, built a three-level linkage, co-construction and sharing model project among provinces, cities and counties, and built a "news+government affairs+service" cloud platform. Two works of Longwan and Ouhai won the third prize of China City Party Newspaper Media Integration Award. Three "official Tik Tok" ranks among the top ten national print media, ranking first in the national newspaper group; Take the lead in introducing AI virtual anchor to municipal media nationwide, and export technology to Ningbo Media Group; Create a new national output model integrating software and hardware of the party newspaper reading screen, and output it to peers inside and outside the province such as Anhui Xuancheng Daily, complete the full coverage of BRT Line 1 and Line 2, and accumulate more than 1,000 sets in the city; "Network Security Brain"The project won the Innovation Award of China Newspaper Media Integration Informatization and Network Security Project in 2019, with five in China and only one in Zhejiang Province.

　　Public opinion leads matrix building　In 2019, Wenbao Group gave full play to the leading role of the party newspaper group in public opinion, and opened up columns such as "East Ou Quick Review", "First Interpretation", "Ou Jiangping", "Group Talk Hall", "Tonight’s Tan" and "Ou Yue Current Review", and published more than 230 comments to promote public opinion to resonate with the city’s reform, opening up and high-quality development. Relying on carriers such as Wenzhou News APP, Wenzhou Publishing, and Rumor Reporting Platform, we actively embed into the public opinion field, stick to mainstream values, tell mainstream stories well, and make mainstream voices. Wenzhou rumor reporting platform released 1193 rumors, including 35 rumors about temperature, with 133 million hits. Especially during the "Lichima" typhoon, Wenbao Group issued a strong party newspaper for the first time, carefully set topics, accurately guided public opinion, and the number of hits exceeded 32.8 million, giving play to the role of public opinion guidance and cohesion. Adhere to the news for the benefit of the people and the convenience of the people, and rely on the brand columns such as "Xinlianxin" Party Representative Studio, Party Newspaper Hotline, Xuejun Studio, News Volunteer Action to Help Farmers, Chen Zhong Charity Studio, Business Newspaper Charity, Wimbledon Love House, etc., and launch the "Xinlianxin" Warm Train, Smile Alliance, Bright Eyes Project, Wenzhou Evening News Public Welfare Ethics Forum, "One Belt and One Road" Wan Li, Love Freezer, "and so on.

　　Overview of Wenzhou Daily　In 2019, Wenzhou Daily published major thematic reports such as the 70th anniversary of the founding of New China, the 70th anniversary of the peaceful liberation of Wenzhou and the 80th anniversary of the first provincial congress, and achieved new results in news propaganda, media integration, management, newspaper distribution and brand building. In the 2019 news award selection, Wenzhou Daily won 14 Zhejiang news awards, and won the innovation award for major theme reporting in the province for the seventh consecutive year. The number of awards and the quality of works ranked first in the provincial party newspapers for the eighth consecutive year. The total annual revenue was 115 million yuan, and the newspaper circulation was close to 120,000, ranking first in the newspaper circulation in southern Zhejiang and northern Fujian.

　　The guidance of public opinion in Wenzhou daily　In 2019, Wenzhou Daily gave full play to the banner role of party newspaper comments, relying on the columns of Oujiangping, Dongou Express Review, Commentators of this newspaper, Group Talk Hall, and Seeking for Depth, aiming at "quickness, precision, accuracy and depth", and interpreted the decision-making arrangements and policy orientation of the Party Committee and government at the first time, responding to public concerns, and strongly launched. Especially around the hot spots such as the construction of "two districts", the super typhoon "Liqima", the withdrawal of Longgang town to set up a city, and the integration of villages and communities, we actively judged public opinions, actively responded to hot spots, and actively set topics. With the spirit of "timely, full and professional", the party newspaper played a clear guiding role in leading public opinion and became the "mainstay" of the four public opinion fields online and offline, official and private.

　　Theme publicity report of Wenzhou Daily　In 2019, Wenzhou Daily planned to launch a series of reports on the major theme of "Flying to Wenzhou for 70 years" throughout the year, with reports such as "Wenzhou for 70 years behind the first", "Letters from heroes", "Memory of my home country" and "Vicissitudes of cultural celebrities" as the main body, forming a tangible and powerful overall reporting framework. Among them, the series of "Letters from Heroes" published more than 50 dynamic reports, with nearly 5 million comprehensive hits on the Internet. Zhejiang Network Publicity Office pushed every report on the whole network, and the total number of clicks of the series of short videos exceeded 10 million. Focusing on the "main line", around the important deployment of the municipal party committee and the municipal government, a series of high-quality presentation and high-density follow-up thematic publicity reports such as "Fighting for 1161, Striving for 2019", "Building Two Districts", "Wenzhou Challenge Hall Six-Match Competition", "Removing Town from Longgang" and "Doing Great Traffic" were planned and launched at the first time, which played the strongest voice of the era of reform and opening up again for Wenzhou’s high-quality development.

　　People’s Livelihood News Report in Wenzhou Daily　In 2019, Wenzhou Daily dug deeply into the touching characters and deeds, set a spiritual benchmark for the new era with advanced models, and reported typical figures with thoughts, temperature and quality, highlighting the brilliance and noble quality of human nature. After the advanced story of "Zhou Jinyong, a firefighter who gave his life to save people and touched the whole city", "Liu Wenzhong, a running brother of Wencheng" and "Shao Yongyin, an excellent teacher who insisted on teaching until the last moment" was published, it was forwarded by the People’s Daily, Xinhua News Agency and other central media, widely publicizing the warm stories and details of Wenzhou, carrying forward the spirit of the times and singing the main theme of advocating morality and doing good. Adhere to the news for the benefit of the people, carefully safeguard the platform for public welfare activities of the Party newspaper, and carry out more than 50 charitable activities by relying on charitable brand activities such as "Warm Train", "Drip Irrigation Bookstore", "Spring Festival travel rush Caring Action" and "Smile Alliance", raising more than 2 million yuan of donations and benefiting more than 30,000 people.

　　Wenzhou Daily’s Brand Activity Building　In 2019, relying on the overall planning of "news+creativity+activities", Wenzhou Daily held the second Oujiangkou Cherry Blossom Festival, Yongjia Qiaoxia Town China Toy Capital International Expo, the first Yunling Cultural Tourism Festival, the non-legacy experience tourism festival, the financial night market, the first Himalayan talks cultural tourism forum, the human settlement exhibition and other brand activities, highlighting the brand strength of the party newspaper and enhancing Wenzhou’s reputation. Among them, the "Magnificent 70 Years of Ou Yue New Era-Wenzhou Celebrating the 70th Anniversary of the Founding of New China" was launched, which became a popular "punch-in point" for citizens and a learning platform and party day activity point for municipal departments to carry out the theme education of "Do not forget your initiative mind, remember the mission" during the National Day holiday. The main exhibition welcomed more than 50,000 people to watch the exhibition. The exhibition tour started in Longwan and ended in Pingyang, with a total of 7 stops. All localities organized four sets of county (city, district) team leaders and county (city, district) departments to watch the exhibition in a unified way, with more than 200,000 visitors.

　　Media Integration of Wenzhou Daily　In 2019, Wenzhou Daily took advantage of the important strategic deployment of the CPC Central Committee to promote media integration. Wenzhou Daily seized the opportunity to overcome difficulties, innovate breakthroughs and accelerate integration in platform construction, content production and all-media planning, and promoted the development of media integration of party newspapers to a higher level and greater effect. On the internal platform, we will optimize the all-media first-level matrices such as Daily Official Micro, Wenzhou News APP, and official Tik Tok. With the renovation and upgrading of the central kitchen, we will open up channels between newspapers, platforms and ports of the Group to realize cross-platform and group-wide content interaction and sharing. At present, there are 8 all-media convergence platforms with a total number of users of more than 4 million. Among them, Wenzhou news client has more than 600,000 users, and Wenzhou publishes more than 750,000 fans. The two distinctive public brands have become the most influential and authoritative mobile media in the city. In terms of external linkage, we should join hands with Taishun, Ouhai and Longwan to develop media integration, speed up the development channel of integration with county-level media, and promote the "three-level linkage of news communication among counties, cities and provinces"; In terms of all-media communication, the integration of traditional editing and editing departments and new media departments is closer and more effective. In the whole year, 144 live broadcasts were launched on the mobile side, 153 topics were released, 684 videos and other flash and promotional videos were produced and released, and 65 H5 works were produced and released, achieving a new breakthrough in new media creation.

　　Theme report of Wenzhou Evening News　In 2019, Wenzhou Evening News published a series of thematic reports, such as "Magnificent 70-year Special Report", "New Kinetic Energy and New Breakthrough-Fighting 1161 and Striving for 2019", "Two Healthy Wenzhou Pioneers", "Transformation Leaps Over Wonderful Butterfly Change" and "Longgang Withdraws Town to Set up City". In terms of serving people’s livelihood, activities such as a charity banquet, a charity street, and a public welfare moral forum were launched. In 2019, he won 2 Zhejiang News Awards; There are 7 news awards in Zhao Chaogou, including 1 grand prize and 3 first prizes.

　　"Yangtze River Delta News" column launched　On September 17, 2019, Wenzhou Evening News began to open a special edition of the "Yangtze River Delta" column in paper media and Wenzhou APP. By the end of the year, more than 100 articles were published in Wenzhou, and 12 special editions were published in paper media. On December 6-7, the editor-in-chief of the Yangtze River Delta Urban Media watched Wenzhou, and invited 30 parents’ triangles such as Xinmin Evening News, Yangzi Evening News and qianjiang evening news and domestic mainstream media to participate, focusing on how Wenzhou integrated into the Yangtze River Delta, and published more than 50 related reports and more than 20 special editions through various forms such as layout, graphics and video H5. On December 11th, the client of Xinhua News Agency published "Integrating into the integration strategy of the Yangtze River Delta, Wenzhou enters the" fast lane "of development". The event received great attention from all walks of life, and set up a media channel and communication bridge for "Wenzhou’s integration into the Yangtze River Delta integration development". It was the first home publicity activity held by Wenzhou around the topic of "Yangtze River Delta integration".

　　The first single series of reports on the national punishment of "low-headed people"　On January 14, 2019, the article "Wenzhou issued the first ticket to punish the" low-headed family "on the zebra crossing" was first published in the Wenzhou Evening News APP, and it was published in the newspaper on January 15, forming widespread concern. People’s Daily praised it; "Review of the Rule of Law" commented: "The good intentions of its legislation are obvious. The legislation and law enforcement are aimed at warning education, and the methods are quite warm, and civilized law enforcement is worthy of recognition." This matter was discussed by more than 100 million people in Weibo, and was reprinted by major national media such as People’s Daily, Xinhua News Agency and CCTV. Baidu searched for nearly 80,000 links. According to the monitoring of Fanwen Information Big Data Platform, as of January 23, 223 media outlets were reprinted nationwide, and the whole network read more than 300 million people. In late April, China Metrology University listed the social hot event of Wenzhou’s first penalty for zebra crossing "low-headed people" in the "Trinity" examination questions. On July 9, Wenzhou’s experience in rectifying the "low-headed family" boarded the learning power APP. On the 8th National Traffic Safety Day on December 2nd, the program group of Central Radio and Television General Station made a special trip to Wenzhou for live broadcast.

　　Media integration of Wenzhou Evening News has been further promoted.　In 2019, after three years of creation, Wenzhou Evening News has more than 3 million users in paper media and "two micro-terminals, one program+Tik Tok". Based on paper media, it has integrated all-media layouts such as pictures, audio, video, H5, VR and live broadcast, forming the influence and cohesion of media integration products on the mobile side, bringing good social benefits. In 2019, through the media column "Finding Families Tribe", we found relatives for 15 relatives and realized family reunion.

　　Media Integration of Wenzhou Metropolis Daily　In 2019, Wenzhou Metropolis Daily enhanced the innovation of media fusion, and focused on the "1+9" media fusion operation system, and increased investment in technology research and development and application. On September 18, 2019, Wenzhou Metropolis Daily took the lead in introducing AI virtual anchor in the national prefecture-level media, and applied it innovatively in video news production based on this artificial intelligence technology. By the end of the year, more than 120 issues of AI broadcast news were produced, with a total reading of over 2.5 million. At the same time, Wenzhou Metropolis Daily has obtained the exclusive agency right of "Iflytek" virtual anchor in the province, and exported AI virtual anchor and applied skills training to many media inside and outside the city. By the end of the year, there were more than 100 platforms of Wenzhou Metropolis Daily’s three-level media integration matrix, including newspapers, APP, websites, WeChat, Tik Tok, Weibo, etc., with a total user of over 10 million, and the reading volume and influence of media integration continued to rise. More than 1,000 short videos of various types were released throughout the year, and the total number of broadcasts on Wenzhou Metropolis Daily’s official Tik Tok number, headline number and handheld Wenzhou platform exceeded 3.5 billion times; The official Tik Tok and headline fans rank first in the same city media; The super typhoon "Lichima" struck, and the total number of readings of Wenzhou Metropolis Daily’s all-media anti-Taiwan disaster relief reports exceeded 24.78 million. The "Palm Wenzhou" client was awarded the title of "Excellent Media Integration Platform of National Party Newspaper".

　　Wenzhou Metropolis Daily’s public opinion guidance has been enhanced.　In 2019, Wenzhou Metropolis Daily adhered to the correct direction of public opinion, focused on Wenzhou’s characteristics, strengthened the awareness of fine products, and launched a series of news works with thoughts, temperature and quality. Going deep into the grass roots and keeping close to the front line, starting from the "little people, short stories and small destiny" under the big theme, nearly 20 columns such as Our Country, Wenzhou No.1 in 70 Years, Theme Education at the Grass Roots, Going Forward to Wenzhou, Two Healthy Wenzhou First, Fighting 1161, Striving for 2019, and Garbage Sorting Wenzhou Action were planned and launched. For example, the series of reports on "Theme Education at the Grassroots Level" tells the vivid stories of Wenzhou’s theme education at the grassroots level, such as the "rebirth" of the first three villages and the "rebirth" of Yongjia Shanzao Village, and achieves good results of "satisfaction of the audience, praise from the industry and praise from the leaders". Based on the hot focus of social and people’s livelihood, paying attention to the blocking points and difficulties discussed by the people, it has successively launched nearly 20 series and more than 70 reports on people’s livelihood supervision, effectively solving the worries of the people, boosting the implementation of the work and seeing practical results. For example, the problem of water accumulation in residential buildings in Puxie City has seriously troubled residents, and photography agencies have suddenly closed their doors after receiving millions of deposits from citizens. It has been reported that all these problems have been properly solved. In the 2018 news awards, Wenzhou Metropolis Daily won 5 Zhejiang news awards and 26 Wenzhou news awards.

　　Wenzhou Metropolis Daily benefits the public.　In 2019, Wenzhou Metropolis Daily relied on livelihood columns such as Chen Zhong Charity Studio to carry out dozens of charity brand activities such as Thumb Project, mobile tea cart and Wendai Pericardia, with a total donation of over 15 million yuan, benefiting more than 100,000 people. Media bridging, enterprise contribution, and people benefit. On March 13, 2019, Thumb Charity Fund held its inaugural ceremony at the Municipal Charity Federation. The "Thumb Project" charity project was sponsored by Wenzhou Daily Newspaper Group in conjunction with Wenzhou Charity Federation, Hand Surgery Branch of Chinese Medical Association, Wenzhou Municipal Committee of Agriculture and Workers Democratic Party, Second Affiliated Hospital of Wenzhou Medical University and China Hand Surgeons Association. By the end of 2018, more than 2 million yuan had been raised to help patients with hand congenital malformation who could not be treated in time due to financial difficulties.

　　Theme report of Wenzhou Business Daily　In 2019, Wenzhou Business Daily highlighted the characteristics of financial media, and planned major theme reports around three main lines: "Celebrating the 70th anniversary of the founding of New China", the establishment of the pioneering area of "two healths" in Wenzhou in the new era, and the theme education of "Do not forget your initiative mind, remember the mission". Throughout the year, a special column of "Fighting 1161 and Striving for 2019" was set up to report the new initiatives of various departments and new trends of various industries in the city. On September 16th, Wenzhou Business Daily launched a series of reports on the theme of National Day, "Magnificent 70-year highlight moment in Wen Shang", which attracted the attention of paper media readers, all-media users, Wen Shang groups and the industry. In the theme planning of Wenzhou’s "Construction of Two Districts", a group of reports with great financial characteristics are planned, so that they are planned every month and climaxed every quarter. We will hold the 2019 Wenzhou Entrepreneurship Youth Model, the 2019 Wenzhou Economic Top Ten People of the Year and the Top Ten Foreign Events in Wen Shang, and strengthen the publicity and reporting of Wenzhou at home and abroad.

　　The Theme Education Report of Wenzhou Business Daily　In 2019, Wenzhou Business Daily focused on people’s livelihood, focused on the implementation of departmental rectification, and urged departments to solve practical problems of the people. Combined with the column of "Micro-observation of Civilization", this paper reports the measures taken by various departments to implement theme education and serve people’s livelihood. Plan the continuous report of "the phenomenon of car blocking at the entrance of the Second Hospital", mobilize experts and people to discuss and unite with departments through reporters’ observation and unannounced visits, and effectively curb the "phenomenon of car blocking" that the masses have greatly reflected. Plan "focusing on the classification of domestic waste", focusing on Wenzhou practices and guiding public opinion hotspots during the period when the General Secretary of the Supreme Leader made important instructions on garbage classification. Open the column of "Serving the People and Solving Difficult Problems", sort out the "changed" and "changed immediately" projects of various departments in time, and dig out news materials for doing practical things for the people. In addition, the special report "Do not forget your initiative mind, Remember the Mission and Praise the Pioneer" was carefully organized. In all walks of life, looking for advanced models at the grass-roots level in Do not forget your initiative mind, and reporting in the form of people’s short messages, was widely praised.

　　Wenzhou Business Daily’s Anti-Taiwan Report　In August, 2019, in the news report on the fight against Typhoon Likima, all-media reporters from Wenzhou Business Daily went deep into Yueqing Dajing, Xianxi, Yongjia Shanzao and other places which suffered the most, and fought continuously for several days, and wrote The reporter experienced the 12-level storm on the island, and walked out of the "island" for help for three hours. The mayor entrusted the reporter to send a message for help: support is needed here! "Fighting for 33 hours in a row and fainting twice in an hour" and a number of rescue and disaster relief reports and typical figures reports, many reports were reprinted and pushed by the provincial media. "Wen Shang" APP broadcasts typhoon information for the first time for 48 hours without interruption, and spreads the first-hand information in time through the form of "text+picture+short video". Innovative means of communication, the launch of a series of anti-Taiwan disaster relief dynamic posters and other new media products. In the post-disaster self-help report, combined with "three AIDS and three reds", the report "One month after the disaster, reporters returned to Yueqing disaster area to see the changes" was launched.

　　Media Integration of Wenzhou Business Daily　In 2019, the new media of Wenzhou Business Daily added a new member-"Wenzhou Business Daily Aauto Quicker". The total number of new media users in Wenzhou Business Daily is more than 3.5 million, doubling on the basis of 2018. In terms of new media and new products, during the "two sessions" in 2019, we planned to launch the new media video products of the two sessions, "Construction of the two districts, representatives have something to say" and "2018 Wenzhou transcripts; The main goals and key tasks in 2019, etc., add artificial gestures and graphic animations to make the video have the effect of sand painting and increase the interactivity and interest of the picture. The reading volume of these two products in Tencent video has exceeded 10,000 people. During the Wenzhou Cultural Fair in March, the Tik Tok Competition of the Cultural Fair was held by the new media of Business Daily, which attracted dozens of Tik Tok net reds from all over the city, and Tik Tok’s works were praised nearly 400,000 times in the final. Headline Media publishes the media Tik Tok list every month, and Wenzhou Business Daily has entered the top 50 national media Tik Tok list for five consecutive months, making it the only print media in Wenzhou to enter the list for five consecutive months. By the end of the year, the Tik Tok number of Wenzhou Business Daily had 2.19 million fans, making it one of Wenzhou print media numbers with the largest number of fans. The typical character report published "Zhou Jinyong, where are you" has been praised for 450,000 times, and "Warrior Zhou Jinyong has returned to the team, but he can no longer go to the police to save people" has been praised for 231,000 times, with a cumulative broadcast volume of over 10 million and nearly 1,000 messages.

　　Love Activities of Wenzhou Business Daily　In 2019, Wenzhou Business Daily planned to launch five public welfare brand activities, such as "Pay tribute to the beautiful Wenzhou builders-send love gloves to sanitation workers", "Pay tribute to the beautiful Wenzhou builders-send lunch on New Year’s Day" and "Crystal Baby". A total of 37 events were held, raising more than 560,000 yuan and benefiting nearly 100,000 people. Wenzhou Branch of Agricultural Bank of China once again launched the activity of "Pay tribute to the beautiful Wenzhou builders-this New Year’s Day, we are your takeaway brother" to send respect and warmth to the builders who are still working overtime. On September 2nd, the second season "Love Freezer" jointly sponsored by Lucheng District Party Committee Propaganda Department and Lucheng District Spiritual Civilization Construction Guidance Center was set up for 33 days, and 80,072 bottles of iced drinks were delivered from 25 supply points in the city. Jointly sponsored by Wenzhou Municipal Committee of Jiu San Society, Yuying Children’s Hospital affiliated to Wenzhou Medical University and Wenzhou Charity Federation, it aims to pay attention to premature babies’ care for their new lives, raise nearly 200,000 donations, and rescue 14 "crystal babies" (13 have recovered and been discharged). In the tenth year, the activity of "100 caring people pair up 100 poor single-parent children" sponsored by the United City Charity Federation has distributed nearly 3 million yuan in matching funds, and more than 900 parents have received matching funding.

　　Exhibition activities of Wenzhou Business Daily　In 2019, Wenzhou Business Daily hosted Wenzhou Cultural Fair, Chuangbo Fair, 100-school and 1000-enterprise matchmaking meeting, held wedding fairs, various auto shows, and participated in organizing and implementing the autumn housing exhibition. Among them, during the 2019 Wenzhou International Fashion Fair, more than 330,500 people visited the exhibition, with a turnover of 341 million yuan and a total exhibition area of 62,000 square meters. More than 500 enterprises and institutions from 23 countries and regions participated. The opening show of ICIF-Flash My People，My Country was widely praised and strongly promoted by the "Learning Power" APP.

Space and vehicle comfort are closely related, and this car is brought to you today. Let’s take a look at it together.

First look at the appearance of the Pentium pony. The front of the Pentium pony looks very simple and generous, which makes people unforgettable. Coupled with tough headlights, it is very eye-catching. The car is equipped with etc. Come to the side of the car, the car body size is 3000MM*1510MM*1630MM, the car uses dignified lines, the car side looks very calm, with large-sized thick-walled tires, the shape is quite dignified. Looking back, the tail line of Pentium pony is fashionable, the taillights are very domineering and the shape is relatively simple.

In terms of interior, the interior modeling has taken a solid route and the visual effect is quite unique. The car looks very good outside the steering wheel, made of plastic, and feels good. Take a look at the central control. The design of the center console is reasonable, which makes the interior design quite layered, which is in line with the temperament of the car. Let’s take a look at the dashboard and seats again. The dashboard of this car presents a flamboyant design style, which is very eye-catching. The car uses a fabric seat, which is wrapped in place and has good support and comfort.

Pentium pony matching gearbox, 30KW, 90N.m, good power performance.

The car is equipped with Bluetooth /WIFI connection, sun visor mirror, USB interface, uphill assist, rear reversing radar and other configurations, which is quite rich in functions, which is undoubtedly very friendly to drivers.

After reading the above description, Xiaobian will make a summary. I wonder if you are excited about this car introduced today?

Human eyes can see all kinds of colors in the visible light band, and ears can hear sounds in the frequency range of 20-20000 Hz, but we still don’t know whether we have the sense of sensing the earth’s magnetic field, which is a complete mystery.

The public calls it "the sixth sense", but scientists don’t like this statement. In the past few decades, they have been trying to pry open the tip of the iceberg of the mystery and find a breakthrough in birds. How do they realize the induction of geomagnetic field and use it? European Robin is an excellent research object. This nocturnal migratory bird has been proved to have the ability of geomagnetic navigation before, and they can use the geomagnetic field as weak as 0.5 gauss for long-distance orientation to complete the seasonal migration year after year.

But what is the mechanism behind it? For this question, it needs a highly interdisciplinary cooperation to answer one or two. At 23: 00 on June 23rd, Beijing time, the top academic journal Nature published a heavy research titled "Magnetic sensitivity of cryptochrome 4 from a migratory songbird" on the cover form, which was jointly completed by scientists from Germany’s Oldenburg University, England’s Oxford University, China Academy of Sciences’ Hefei Institute of Material Science, Purdue University, University of Texas Southwest Medical Center and Germany’s Freiburg University. Studies have proved that cryptochrome protein (Cry4) in birds’ retina is very sensitive to magnetic field, and it may be the long-sought magnetic sensor.

There are 6 corresponding authors in this study, one of whom is Xie Can, a researcher from the High Magnetic Field Science Center of Hefei Institute of Material Science, China Academy of Sciences, and the High Magnetic Field Science Center is the common communication unit. Together with the team of the University of Oldenburg, Xie Can’s laboratory successfully prepared and obtained the Cry protein of European robin, a nocturnal migratory bird, for the first time in the laboratory, which laid the foundation for the success of the whole study.

In an interview with The Paper (www.thepaper.cn), Xie Can said that this multi-party cooperation, which started in 2016, is only the first stage of research on biomagnetic induction in various laboratories. "This article is also the first stage of our long-term cooperation." There is still a lot of work to be explored by its laboratories and partners in the future.

Xie Can graduated from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2001 with a doctorate in science. In August of the same year, he went to the United States to study molecular biophysics and structural biology in Timothy Springer laboratory of Harvard Medical School. From 2009 to 2019, he was a professor at Peking University College of Life Sciences. In November 2019, he was invited to join and transferred to the High Magnetic Field Science Center of China Academy of Sciences as a researcher. In December, 2020, we jointly established the International Magnetic Biology Frontier Research Center (IMF RC).

It is worth mentioning that in 2016, Xie Can Laboratory published its original breakthrough in the field of animal magnetic induction and biological navigation in the international academic journal Nature Materials, and discovered the magnetic receptor gene for animals’ perception of magnetic field for the first time in the world. The magnetic induction protein (MagR) encoded by this gene has intrinsic magnetism and can form a complex with Cry protein, so as to recognize the external magnetic field and respond. Based on this, Xie can put forward the hypothesis of "biological compass" for animals to feel magnetism. This work was rated as "Top Ten Progress in Life Sciences in China in 2015".

Professor Peter Hore from the Laboratory of Physical and Theoretical Chemistry of the Department of Chemistry of Oxford University is also the corresponding author of this latest study. Hore is one of the main schools of biological magnetic induction hypothesis, that is, the main contributor to the chemical radical-pair model that relies on cryptochrome. In an email to The Paper (www.thepaper.cn), he wrote, "If we can prove that Cry4 is a magnetic receptor molecule, we will also prove a fundamental quantum mechanism, which enables animals to perceive extremely weak environmental stimuli, and the intensity of this stimulus is one million times weaker than previously thought".

Referring to the above hypothesis of chemical free radicals, the time should be set back to 1978. At that time, German chemist Klaus Schulten and others proposed a preliminary model to introduce quantum entanglement into this research field, arguing that the magnetic induction mechanism of birds involves the entangled state of free radical pairs. Schulten’s team finally published the research results in 2000, pointing out that cryptochrome is probably the key molecule in the process of bird magnetic navigation, and boldly speculated on the magnetic induction process.

After nearly 20 years’ development, the outline of this hypothesis has become increasingly clear: firstly, the photosensitive pigment auxiliary group FAD in cryptochrome absorbs the energy of a blue photon, which causes the electronic transition of FAD group, leaving an empty orbit; Then the electrons are taken from the four adjacent tryptophan in turn, which is "electron transfer". At this time, the separated electrons have both spin singlet and triplet states due to quantum entanglement. Finally, the delicate balance between the two states can be determined by the direction of geomagnetic field, and this information can be transmitted to the brain in some way, so that organisms can respond to geomagnetic information.

The research team systematically and completely summarized the basic principles and supporting evidence of the free radical pair hypothesis from physics, chemistry and biology.

Compared with the previous theoretical research, this multi-party cooperative research takes the cryptochrome 4 protein of European robin as the main research object, carries out a series of high-precision spectroscopic tests, and carries out computational biology simulation, thus realizing the mutual verification of theory and experiment. This is the first comprehensive explanation of the photochemical magnetic sensitivity of free radicals in cryptochrome protein of nocturnal migratory birds, which confirms and perfects the magnetic induction mechanism of free radicals and provides an important basis for further explaining the geomagnetic orientation behavior of migratory birds.

Functional Cry4 protein from migratory birds

As early as 2000, scientists proposed that the photosensitive protein cryptochrome (Cry) was a possible magnetic induction protein through theoretical calculation. Theoretically, under the blue light condition, the information of external magnetic field can be transformed into the change of quantum yield caused by photoinduced free radicals in cryptochrome protein, which can be perceived by cells.

Why is cryptochrome protein considered by scientists as an animal magnetic induction molecule? The first author of this paper, Xu Jingjing from the University of Oldenburg, explained to the reporter of The Paper (www.thepaper.cn) that cryptochrome protein can bind to flavin adenine dinucleotide (FAD), also known as active vitamin B2. When FAD is excited by blue light, it will undergo a reduction reaction, which can seize the electrons of tryptophan (Trp) nearby in turn, thus forming a magnetically sensitive free radical pair [FAD-TrpH+].

"It can be said that FAD is the’ heart’ of this magnetic sensitive molecule, and only cryptochrome protein combined with the cofactor FAD has the prerequisite of magnetic sensitivity." Xu Jingjing is now a doctoral student in Henrik Mouritsen’s laboratory of the University of Oldenburg. Before studying in Germany, Xu Jingjing completed his master’s degree in the Institute of Electrician, Chinese Academy of Sciences, and received biochemical training in Professor Xie Can’s laboratory. .

It is worth mentioning that one of the reasons why the hypothesis of free radical magnetic induction has not been proved by experiments in birds since it was put forward in 1978 is that the recombinant expression of avian cryptochrome protein often loses its own function because of protein’s misfolding, which means the loss of the key auxiliary group FAD for cryptochrome.

"The biggest regret of free radicals to the hypothesis is that scientists have never been able to obtain experimental evidence of the magnetic sensitivity of cryptochrome protein in migratory birds. In the early attempts, some experiments were done in the laboratory with cryptochrome protein of plants or non-migratory animals, but as the most typical migratory animals, migratory birds have never been really studied because of the difficulty in purifying cryptochrome protein of birds. " Xie can added.

In this study, scientists finally obtained the functional cryptochrome protein of migratory birds that combined with FAD. Under the guidance of Xie Can and Mouritsen, Xu Jingjing expressed and purified Cry4 protein of nocturnal migratory birds with biological activity by using the Cold-Shock protein expression system customized and optimized in the laboratory. The protein sample showed a beautiful and transparent yellow-green color due to the presence of FAD chromophore, and mass spectrometry analysis showed that the FAD binding rate of the protein was as high as 97%. It laid the foundation for the success of the whole study.

The acquisition of Cry4 protein of European robin is actually quite tortuous. Xie Can told the The Paper reporter that as early as the beginning of the cooperation, that is, in April 2016, the original plan was that Xie Can’s laboratory would prepare the protein in China, and then send it to the foreign cooperation team by air transportation for the next test.

In the previous research on MagR, Xie Can has successfully expressed and purified the MagR and Cry proteins of homing pigeons (birds that can homing directionally but not migrate seasonally) and their complexes.

But the international transportation scheme is not feasible. Xie Can clearly remembers that on June 9, 2016, his laboratory sent samples to Oxford University for the first time, but it was difficult. "Long-distance international transportation of protein samples requires that the protein be frozen first, and then thawed after reaching the destination laboratory. At that time, we found a problem. Whether it is Cry protein, MagR protein discovered by ourselves, or a complex of the two, all these proteins related to magnetic induction are very unstable and extremely sensitive to temperature. In the process of freezing and thawing, the activity of protein is greatly reduced or even disappeared. " For Cry4 protein in this study, after long-distance transportation and freezing and thawing, the key FAD auxiliary group was dissociated from Cry4 protein, and Cry4 protein also lost its activity.

Under the circumstances at that time, how to "preserve" Cry protein was an urgent problem to be solved. Just then, Xu Jingjing was applying for a visiting scholar in Mouritsen Laboratory. In November 2016, Mouritsen put forward a proposal to let Xu Jingjing go directly to Xie Can’s laboratory to learn a whole set of protein expression and purification techniques. Under the framework of cooperation, Xie can is very open-minded. "This is also a good thing for us, because the articles we publish ourselves also hope that others can repeat them." After more than two months of intensive "crash course", Xu Jingjing entered the Mouritsen laboratory.

"It took about seven or eight months for Xu Jingjing to set up the whole system from scratch in Mouritsen laboratory, and the expression and purification of Cry4 protein were perfectly repeated, and it also had good activity." After the key cornerstone work was completed, Hore and Mouritsen could not hide their excitement. They expressed their excitement in the email sent to Xie Can, that is, at that moment, the three parties formally established a long-term cooperation. "The three of us are completely different backgrounds. Hore is a physicist, so he mainly does physical chemistry. Mouritsen does animal behavior and neurobiology. I do protein research, so the three of us have their own strengths, which can complement each other." Xie Can described this tripartite cooperation in this way.

　In the following two years, Xu Jingjing usually finished protein preparation in the morning, then took a flight from Germany to Britain, arrived at Oxford University in the afternoon and went straight to the laboratory to test the properties of the protein, that is, the magnetic sensitivity of free radicals to photochemical reactions. Xie can once "experienced half a trip" when she visited Oxford University. "I can realize that she basically shuttled between laboratories in two countries for more than two years, and this is how the experiment was done." Xie can said.

For the first time, the hypothesis of free radical pair was verified by the experiment of cryptochrome protein of migratory birds

In the course of this research, in view of the complexity of the experimental content and the extremely complicated tests involved, more laboratories joined in. It is mentioned in the paper that in order to study the influence of magnetic field on the photochemistry of cryptochrome, the research team has developed and continuously improved a variety of spectral techniques.

The research team of Oxford University has developed a series of spectroscopic techniques specially used to study the photochemical magnetic field effect of cryptochrome, including transient absorption spectroscopy and Cavity ring-down spectroscopy. Broadband cavity-enhanced absorption spectroscopy and electron paramagnetic resonance. Hore described it this way, "These devices were developed by the joint efforts of generations of talented postdoctoral and graduate students in the laboratory for many years."

Xu Jingjing said, simply put, the researchers put the protein sample in a magnetic field and irradiated it with 450nm blue light to detect the light absorption changes of the protein transient free radical pair under different magnetic field conditions and different time resolutions.

The experimental results showed that the free radicals in cryptochrome protein changed the yield after the magnetic field was applied, that is, the magnetic field effect, and the magnetic field effect of cryptochrome protein of European robin was 10 to 20 times stronger than that of non-migratory birds (chickens and pigeons).

The research team also clarified the mechanism of this magnetic sensitivity, that is, the electron transfer reaction triggered by blue light absorption. Protein molecule is composed of a series of amino acids: Cry4 has 527 amino acids, of which 4 tryptophan is very important for magnetic sensitivity. Under the excitation of blue light, electrons jump between FAD and these four tryptophan, resulting in so-called magnetically induced free radical pairs. Peter Hore of Oxford University and Ilia Solov’yov, a physicist in oldenburg, have calculated quantum mechanics to support this view.

In order to verify this, researchers at the University of Oldenburg further prepared tryptophan mutant protein of cryptochrome, that is, four tryptophan (WA, WB, WC and WD) in the electron transfer chain were replaced by phenylalanine (F) in turn, which had no redox activity and could not provide electrons to FAD, thus cutting off the electron transfer chain.

In each mutant protein, the electron transfer chain is 3, 2 and 1 tryptophan in turn. The transient absorption spectrum test results show that the free radical pair life of mutant protein is shortened from microsecond to nanosecond and picosecond. Electron paramagnetic resonance (EPR) test showed that the free radicals of wild-type protein [FAD+TRPDH+] were 2.2nm apart, and after the fourth tryptophan was mutated, the free radical pair [FAD+TRPCH+] was 1.8nm apart.

The paper points out that the experimental results are consistent with the theoretical simulation. In wild-type cryptochrome protein, electrons are transferred among four tryptophan in turn, and these four steps make the electrons that are not equipped at the end be the farthest apart, thus forming a long-lived free radical pair, and the ultra-fine effect of the latter’s spin coherence is the point of magnetic field action.

Xu Jingjing mentioned that, surprisingly, when the fourth tryptophan at the farthest end was mutated, the magnetic field effect of protein was stronger than that of wild-type protein, and it was stronger than that of cryptochrome in Arabidopsis thaliana, which is also an electron transfer chain of tryptophan.

The researchers asked, why did nature evolve a fourth tryptophan for avian cryptochrome protein, if its function was only to reduce the sensitivity of magnetic field? Further research shows that the decay kinetics of wild-type protein (ErCry4) and mutant (ErCry4 WDF) are similar in milliseconds, and the magnetic field dichotomy (B1/2) is similar. This means that the origin of their magnetic sensitivity is the same, both of them come from the third tryptophan, and the fourth tryptophan may not participate in the animal magnetic induction process.

So what role does this fourth tryptophan-mediated electron transfer play? Based on the above experimental results, Ilia Solov’yov and Hore put forward the mechanism of free pair dynamic equilibrium through spin dynamic simulation, that is, electrons may jump back and forth between the third and fourth tryptophan, and the resulting two free radical pairs [FAD-TRPCH+] and [FAD+TRPDH+] are in rapid dynamic equilibrium and play different roles respectively.

The two roles are: the free radical pair formed by flavin-third tryptophan is mainly responsible for magnetic field perception, and the free radical pair formed by flavin-fourth tryptophan is mainly responsible for biochemical signal transmission in vivo. "This mechanism has not been found in cryptochrome proteins of any species before." Xie can said.

The research team predicts that there may be other proteins interacting with cryptochrome proteins in the body, such as MagR or other unidentified signal molecules reported by Xie Can, to realize cascade amplification of signals or directional arrangement of cryptochrome proteins, and further enhance the magnetic sensitivity and direction recognition in organisms. "Of course, these speculations need more experiments in the future to confirm."

They speculated that, perhaps, it was through this ingenious mechanism that nature wonderfully optimized the free radical photochemical reaction of cryptochrome protein and realized the dual functions of magnetic field sensing and signal transmission, thus enabling migratory birds to find their way in their journey across the hemisphere.

Xie Can concluded to the The Paper reporter that the main breakthroughs of this study are as follows: first, the hypothesis of free radical pair is verified experimentally with cryptochrome protein of migratory birds; Secondly, it is found that cryptochrome protein 4 of migratory birds is more sensitive to magnetic field than that of non-migratory birds; Thirdly, it is found for the first time that the four conserved tryptophan in the hypothesis have two different functions: magnetic induction and signal transmission.

Moving forward in controversy, in vivo verification is not easy.

It is worth noting that there are still many controversies in the field of animal magnetic induction research.

Xie Can said that on the whole, the magnetic induction hypothesis that has attracted much attention so far mainly includes electromagnetic induction model, magnetite particle model, chemical free radical pair model dependent on cryptochrome and biological compass model. These hypotheses are supported by certain experimental evidence, but there are also some limitations or deficiencies.

Xie Can called the study of animal magnetic induction a "very non-biological" study. By analogy with the conventional research ideas of sensory biology, scientists have first known for sure the existence of a certain sensory system and what kind of sensory organ it is, and on this basis, they have identified the receptor cells, neural pathways and brain regions related to the sensory system.

But the study of magnetic induction is quite different. In this field, biologists often find and ask questions, but physicists put forward imaginative hypotheses, and then chemists will also participate in a large number of verification experiments. Previously, the discovery of MagR and the hypothesis of biological compass in Xie Can’s laboratory generally followed this thinking paradigm.

Although this latest research has made many important breakthroughs, Hore stressed that this is not conclusive evidence that cryptochrome is a magnetic sensor. Because "this study is an in vitro experiment with purified protein, and the magnetic field used in the experiment is much higher than the geomagnetic field." Henrik Mouritsen said, "We need to prove the sensitivity of this protein to geomagnetic field in birds’ eyes, but the current technical bottleneck does not allow us to do this."

The research team speculated that cryptochrome protein may show higher sensitivity to magnetic field in vivo environment. For example, in retinal cells, protein may be arranged in a fixed orientation, thus enhancing their sensitivity to the direction of magnetic field. In addition, they may interact with other proteins, such as the previously reported magnetic receptor MagR, and even other unidentified protein, so as to achieve the effect of signal cascade amplification. Scientists are also looking for these unknown "mutual partners".

Regarding the future research plan of this project, Xu Jingjing pointed out that finding the interaction protein of cryptochrome and conducting in vivo experiments are two major challenges.

In fact, up to now, even though the evidence of free radicals is the most comprehensive, many hypotheses of animal magnetic induction mechanism need to be continuously developed, improved and screened. "There are many schools in the field of magnetic induction, and the publication of every research result needs to be widely questioned and challenged by reviewers in the review process, and these reviewers often come from different academic schools with different academic viewpoints, and they are often your competitors. Only by persuading your competitors will it be possible to finally publish it through review. " The review of this paper for nearly two years also highlights the twists and turns of the process.

Xie can prefers to call this kind of controversy in the scientific community academic debate. "The extensive academic controversy and debate itself shows that the problem you are studying is very important, which is obvious." Secondly, Xie Can believes that with the academic controversy and debate, it often brings about the rapid development of the whole field, "because more and more rigorous experiments will be designed to verify their respective views. Whether it is proof or falsification, we are getting closer and closer to the truth of science. "

Xie Can believes that the field of animal magnetic induction is full of controversy, "because no hypothesis or model has been recognized by everyone so far, and each school has its own supporters."

Strong cooperation like this one may bring about accelerated progress. "This is a highly interdisciplinary field. If you want to do some interesting topics in the field of animal magnetic induction and biological navigation, it is often impossible to rely on a laboratory to complete it." Xie can said.

Xu Jingjing also mentioned that "solving a scientific problem requires the joint efforts of many disciplines. In our team, experts in various disciplines have world-class technology, which is very important for our research." She said that in the process of project promotion, researchers kept communicating and understanding the knowledge of different disciplines to achieve common scientific goals.