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Analysis and Prospect of Global Pharmaceutical Market in 2017-2022

I. Market size and growth rate

the year 2017The global prescription drug market size is$774 billion, estimated from 2017 to 2022.The annual growth rate of CAGR is 6.5%By 2022, the prescription drug market will exceed the trillion-dollar level for the first time, reaching$1.06 trillion. CAGR exceeds that in the field of instruments5.1%.

Prescription drug market is divided intoPrescription drugs (except generic drugs and Orphan drugs), generic drugs and orphan drugs.Three market segments. Among them,generic drugsIn 2017-2022, the scale of the overall prescription drug market will be10%-11%The annual growth rate of CAGR is slightly lower than that of the overall prescription drug market.6.0%The market scale will be from 2017.$84 billionGrowing to 2022$112 billion; Annual growth rate of orphan drugs in 2017-2022CAGR was 11.2%, a rare double-digit growth, the market size will be from 2017.$123 billionrise to$209 billion, accounting for the overall prescription drug market size will be from15.9% in 2017rise to19.7% in 2022.

Although the expected market share can be increased, in fact, the proportion will remain basically unchanged in the next five years; The proportion of orphan drugs has steadily increased.

2. What is the impact of the patent cliff?

It is expected to be from 2017 to 2022.$194 billionThe drug market is facingPatent cliff patent cliffThe challenge is mainly due toBiosimilar, a biosimilarIn the previous article, I also shared the market of Biosimilar, the global biosimilar market and competition analysis |Q said. This patent cliff may be fromThe first patent cliff in 2012After the second patent cliff peak.

Of course, there are still some variables in the future who will eat this big cake in the generic drug market. In addition to companies that focus on generic drugs,Big pharmaceutical companiesNow I have also found a way. If my patented drug expires, I can authorize it to be authorized generics, which is exactly the same as the original patented drug, except that the trademark is removed and the price is lower, and the regulatory authorities do not have to work hard to approve it. Regarding the definition of Authorized Generics, FDA gives the following explanation.

The term “authorized generic” drug is most commonly used to describe an　approved brand name drug that is marketed without the brand name on its label. Other than the fact that it does not have the brand name on its label, it is the　exact same drug product as the branded product.An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. In some cases, even though it is the same as the brand name product, a company may choose to sell the authorized generic　at a lower cost　than the brand name drug.

Many big pharmaceutical companies have begun to plan this.Instead of letting others eat the cake, it is better to distribute it yourself or share it with others.; The time and method of specific sales are also controllable; Why not?

III. What are the hot treatment areas?　

fromFrom the perspective of Biotech, a biological medicine, and Conventional medicine, Conventionality.Look, 2017-2022Biological medicineThe proportion of the overall market has steadily increased and tends to be flat, and will be from26% in 2017 increased to 30% in 2022.; At the same time, biopharmaceutical head productsTop 100 productsThe proportion of total biopharmaceuticals is from 2016.49%Increased to 202252%.

fromTreatment areaLooking at it, the following ten areas have the largest market scale.

（1）Oncology of tumorIt is still the largest market segment, with CAGR in 2016-2022.12.7%Will reach in 2022.$192.2 billionSales, accounting for global market share17.5%.

（2）Diabetes Anti-diabeticsIt is the second largest market segment, with CAGR in 2016-2022.4.8%Will reach in 2022.$57.9 billionSales, accounting for global market share5.3%.

（3）Rheumatism Anti-rheumaticsIt is the third largest market segment, with CAGR in 2016-2022.0.6%Will reach in 2022.$55.4 billionSales, accounting for global market share5.0%.

（4）be antiviralAnti-virusIt is the fourth largest market segment, with CAGR in 2016-2022.-2.1%Will reach in 2022.428Billion dollarsSales, accounting for global market share3.9%. fornegative growthSo Gilead is nervous.

（5）Vaccine VaccinesIt is the fifth largest market segment, with CAGR in 2016-2022.4.2%Will reach in 2022.353Billion dollarsSales, accounting for global market share3.2%.

（6）Bronchodilators of respiratory system bronchusIt is the sixth largest market segment, with CAGR in 2016-2022.1.0%Will reach in 2022.301Billion dollarsSales, accounting for global market share2.7%.

（7）Sensory organsIt is the seventh largest market segment, with CAGR in 2016-2022.five.8%Will reach in 2022.283Billion dollarsSales, accounting for global market share2.6%.

（8）Immunosuppressant ImmunosuppresantsIt is the eighth largest market segment, and the CAGR in 2016-2022 is14.6%Will reach in 2022.263Billion dollarsSales, accounting for global market share2.4%. This field is one of all fields.The fastest growth rateYes.

(9) Hypertension Anti-hypertensives is the ninth largest market segment, and the CAGR in 2016-2022 is-0.2%Will reach in 2022.244Billion dollarsSales, accounting for global market share2.2%.

（10）Cardiovascular Anti-coagulantsIt is the tenth largest market segment, and the CAGR in 2016-2022 iseight.6%Will reach in 2022.232Billion dollarsSales, accounting for global market share2.1%.

By 2022,Top Five Top5 Tumor DrugsWill beCelgeneThe company’s immunomodulatorRevlimid、BMScorporatePD1 antibody Opdivo, Merck’sPD1 antibody Keytruda、AbbViecorporateBTK inhibitor Imbruvica、PfizercorporateCDK inhibitor Ibrance. The next five years will bePD1The overbearing world adds up to the tumor market.10%.

4. How much does it cost to develop new drugs?

First of all, the big pharmaceutical companiesAt present, R&D investment has accounted for about 20% of the sales revenue ratio.. Without research and development, there will be no new products, and cruel competition will push you out of the market.

Secondly,On average, each new drug NME(New Molecular Entity) costs $5 billion.. $5 billion is definitely not a small figure, which exceeds the previous cost.

Furthermore, according to the sales in the United States after the approval of the new drug,The annual sales of each NME in the fifth year is about $522 million.. According to the current Hacth-waxman Act, the new drug NME has5 years of data exclusivityandThree years of market exclusivity,　After that, generic drugs went on the market. It is necessary for pharmaceutical companies to expand indications, conduct more research and development, or cooperate in research and development as soon as possible.

5. Who are the top ten pharmaceutical companies?

First place,Novartis NovartisIn 2016-2022, CAGR is3%, sales reached in 2022.49.8 billion dollars, accounting for market share4.7%.

Second place,Pfizer PfizerIn 2016-2022, CAGR is1%, sales reached in 2022.49.7 billion dollars, accounting for market share4.7%.

Third place,Roche RocheIn 2016-2022, CAGR is4%, sales reached in 2022.$49.6 billion, accounting for market share4.7%.

Fourth place,Sanofi sanofiIn 2016-2022, CAGR is3%, sales reached in 2022.$41.7 billion, accounting for market share3.9%.

Fifth place,Johnson&JohnsonIn 2016-2022, CAGR is4%, sales reached in 2022.$40.5 billion, accounting for market share3.8%.

Sixth place,Merck&CoIn 2016-2022, CAGR is1%, sales reached in 2022.$38.5 billion, accounting for market share3.6%.

Seventh place,AbbVie in AbbwayIn 2016-2022, CAGR is5%, sales reached in 2022.$34 billion, accounting for market share3.2%.

Eighth place,GlaxoSmithKlineIn 2016-2022, CAGR is3%, sales reached in 2022.$33.7 billion, accounting for market share3.2%.

Ninth place,AstraZeneca AstraZenecaIn 2016-2022, CAGR is5%, sales reached in 2022.$28.4 billion, accounting for market share2.7%.

Tenth place,Xinji pharmaceutical CelgeneIn 2016-2022, CAGR is15%, sales reached in 2022.$26 billion, accounting for market share2.5%.

It can be seen that the top three are very tight, and the rankings have not changed much. Pfizer has retreated to the second place, Novartis has jumped to the first place, and Roche is still firmly in the third place.

Gilead fell out of the top ten.

Celgene jumped 11 places into the top ten.

This article was originally published on WeChat WeChat official account’s "Investment and Life of the Owner of Q Village".

A large car of 919,000 yuan that is suitable for driving home for the New Year, which one is the most worth choosing？

The change in shape design is still relatively positive, and the new model looks more fashionable. The lower grille is enlarged and matched with the "BMW" logo, which makes the gas field of the front face of the vehicle look domineering, and the slender headlights look very energetic after being lit. Judging from the waistline on the side of the car body, the new car is still a solemn appearance, and the tradition of wide C-pillar can be continued. In addition, with the design of 20-inch multi-frame wheels, its sports atmosphere is more intense. The horizontal development of the duck tail with two long and slender taillights is more stable, and the details of the through taillights have become more beautiful after being redrawn.

In the car, the new car adopts BMW’s latest design style and layout, which is very harmonious as a whole. Configuration is definitely one of the strengths of BMW 7 Series. The car is equipped with an electric four-way adjustable leather steering wheel and a shift paddle, which is very practical. The center console is made of plastic and leather, and the materials and workmanship look quite satisfactory. The front row is also equipped with a dual-temperature automatic air conditioning control system to freely debug the most comfortable space atmosphere. Leather seats look cute.

The length of the BMW 7 Series is 5391mm, the body width is 1950mm and the wheelbase is 3215mm, which is quite satisfactory. In the same class, the wheelbase of the BMW 7 Series ranks 12th. As a car, its body size does not occupy much advantage in its class, and its internal seating space is only basically enough. After all, it is limited by the length and shape of the car body. The design of skylight also increases the subjective space feeling of front and rear passengers. Among the models of the same price and class, the trunk volume of BMW 7 Series ranks 23rd. Spatial performance is limited by vehicle positioning, and the performance is acceptable, and the flatness is no problem, but the total space is average.

The BMW 7 Series is equipped with a combination of 3.0 turbocharged engine (direct injection) and automatic manual (AT). The power performance of 3.0 engine matched with BMW 7 Series is quite satisfactory, the low torque is weak and the hysteresis can be felt. The official measured acceleration of the BMW 7 Series is 5.4S, ranking 20th among more than 800,000 car models.

The active/passive safety configuration of BMW 7 Series is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

If the above data and participation can’t fully understand the BMW 7 Series, then we can give you a more comprehensive reference based on the word-of-mouth information of users who have purchased the BMW 7 Series in history. It can be seen that what everyone is most satisfied with the BMW 7 Series is that its acceleration is very stable. In addition, the interior is very good and the seats are delicate, which is what everyone likes about it.

Notice of Beijing Municipal Bureau of Economy and Information Technology on Organizing the Publication of the Second Batch of Foundation Construction Projects for High-tech Industries in 2023

　　In order to implement the decision-making arrangements of the municipal party committee and the municipal government on upgrading the modernization level of the industrial chain supply chain, and accelerate the construction of an international science and technology innovation center, according to the deployment of the "Development Plan for High-tech Industries in Beijing during the Tenth Five-Year Plan", based on enhancing the independent and controllable capabilities of the industrial chain and supply chain, focusing on the weak links of the industry, and carrying out the engineering research on key basic technologies and products, the second batch of high-tech industry foundation projects will be organized and unveiled in 2023.

　　First, the research direction and support standards

　　(A) the direction of tackling key problems

　　1. The field of hydrogen energy

　　(1) Direction of combined valve of 1)70MPa automobile hydrogen bottle

　　2. Field of medical robots

　　(1) High real-time tracking and intelligent navigation device for surgical robot.

　　(2) Robot intelligent mobile platform

　　(3) fracture reduction operation planning and control system

　　3. The field of cell and gene therapy drugs

　　(1)GMP-level transfection reagent

　　(2) Cell cryopreservation solution

　　(3) Cell reprogramming reagent

　　(4) Cell cryopreservation bag

　　(5) Large magnetic frame

　　(6) Cell washing, concentration and liquid exchange equipment with ultra-Qualcomm capacity.

　　(7) Gene Transduction Equipment

　　4. Cloud native domain

　　(1)OpenNJet HTTP3 state secret SSL suite module　

　　(2)OpenNJet HTTP3 proxy module

　　(3)OpenNJet MQTT protocol proxy module

　　(4)OpenNJet WASM module

　　(5)OpenNJet HTTP3 proxy enhancement module.

　　(6)OpenNJet dynamic protocol plug-in module

　　5. Database field (distributed relational type)

　　(1) Research and development of key algorithms and module technologies for heterogeneous database migration.

　　(2) Supporting standards

　　For the project units registered in our city, support shall be given according to 30% of the investment for tackling key problems approved by the project, and the amount of support in a single direction shall not exceed 30 million yuan, and the funds shall be allocated annually.

　　Second, the reporting requirements and instructions

　　(a) reporting conditions and requirements

　　1 to encourage enterprises and consortia with the ability to tackle key problems nationwide to expose the list. The party receiving the list should be in good operation and financial condition, and have no serious record of dishonesty in the past three years.

　　2. The construction site of the project is in this city, which meets the requirements of this city’s industrial policy and has complete procedures. The research period should not exceed 3 years, and the start time should be later than January 1, 2023.

　　3 to declare the project should not be supported by other municipal financial funds.

　　4. The applicant shall submit the application materials as required. The applicant voluntarily fills in relevant materials, promises relevant matters, and is responsible for the authenticity and accuracy of the materials provided.

　　(2) Time and process of declaration

　　1. Detailed indicators and parameters of the research direction can be obtained by consulting the corresponding business offices in each direction (see Annex 2 for details).

　　2. Eligible reporting units, please submit the materials (three sets of paper version and one set of electronic version) to the corresponding business offices in all directions as required (see the annex for details) before October 20, 2023. Paper version materials shall be made in accordance with A4 paper binding, and the cover and riding seam shall be stamped with the official seal of the project reporting unit.

　　(3) Other matters

　　1. The project unit shall carry out project management in accordance with the Measures of Beijing Municipality for the Management of Development Funds for High-tech Industries, and accept the follow-up inspection, acceptance review and performance supervision by the relevant departments of the urban area, such as the letter, finance and so on. In case of concealment, concealment, fraud or violation of commitments, Beijing Economic and Information Technology Bureau has the right to pursue relevant legal responsibilities and recover funds. At the same time, it will incorporate the untrustworthy information of the project unit into the Beijing public credit information service platform and implement credit punishment according to laws and regulations.

　　2. Contact person for policy consultation:

　　Planning Department: Zong Zhigang, 55578586; Zou Genhong, 55578179.

　　Technical support: customer service staff of Beijing Tongqi Service APP, 82176966; Beijing high-tech industrial development fund system operation and maintenance personnel, 55578555.

National Health Commission： Strengthen the coordinated development of medical insurance and medicine

At the press conference held by the National Health and Wellness Committee on February 28th on the progress and effectiveness of health and wellness, Mi Feng, spokesperson of the Committee and deputy director of the Propaganda Department, introduced that the main health indicators of Chinese residents are currently in the forefront of middle-and high-income countries.

Continuously meet the health service needs of the people.

Zhuang Ning, deputy director of the Department of Physical Reform of the National Health and Wellness Commission, said that in recent years, the National Health and Wellness Commission has actively played a leading and coordinating role in medical reform and strengthened the coordinated development of medical care, medical insurance and medicine with relevant departments.

Zhuang Ning introduced that in terms of medical care, through the layout and construction of national medical centers, national regional medical centers, and provincial regional medical centers, we will strengthen relevant clinical key specialties and solve the problem of people seeking medical treatment across regions. According to statistics, in the first four batches of 76 national regional medical centers, more than 460 specialties have been built and more than 6,200 new medical technologies have been developed, and the average number of patients transferred to hospitals has dropped by about 30% compared with that before construction. The rate of common and frequently-occurring diseases in the county is over 90%.

Public hospitals are the main body of China’s medical service system. According to Jiao Yahui, director of the Department of Medical Administration of the National Health and Wellness Commission, there are 2,817 tertiary public hospitals and 5,384 secondary public hospitals participating in the performance appraisal of public hospitals nationwide. According to the data of the past five years, the development mode, operation mode and resource allocation of tertiary public hospitals in China are more reasonable. The two indexes reflecting the technical difficulty of medical services, namely, the case combination index and the proportion of discharged patients in Grade IV surgery, have increased by 10% and 23.5% respectively, and the application level of electronic medical records in 83% tertiary public hospitals has reached Grade IV or above. The number and proportion of doctors in short supply such as anesthesiology, pediatrics, and severe diseases in tertiary public hospitals across the country have increased, constantly meeting the needs of people’s health services.

Zhuang Ning said that in terms of medical insurance, China has further improved the universal medical insurance system, raised the per capita financial subsidy standard for residents’ medical insurance to 640 yuan, and continuously improved the level of general outpatient medical insurance for employees. In medicine, we will further expand the breadth and depth of centralized procurement of pharmaceutical consumables and further reduce the inflated price. Revise and improve the medical insurance drug list, improve the basic drug system, speed up the registration and listing of urgently needed drugs, children’s drugs and innovative medical devices, and strive to meet the people’s drug demand.

Continuously improve the ability of disease prevention and control

In recent years, China has continuously improved the multi-sectoral cooperation mechanism to enhance the ability of disease prevention and control. Qin Xingqiang, deputy director of the Comprehensive Department of the National Bureau of Disease Control and Prevention, said that the laws, regulations and policy systems related to the emergency response of infectious diseases in China have been continuously improved, and the emergency management system and mechanism have been continuously optimized, basically forming an emergency plan for public health emergencies, covering multiple diseases and covering national, provincial, municipal and county levels. Relying on the national and provincial centers for disease control and prevention, 20 national teams for the prevention and control of sudden acute infectious diseases have been set up, covering 17 provinces.

According to reports, since the "14 th Five-Year Plan", the central budget has allocated a total of 13.1 billion yuan to support the construction of disease control systems at the national, provincial, municipal and county levels. In 2023, the central government allocated 17.687 billion yuan for disease control projects through transfer payment for the prevention and control of major infectious diseases and endemic diseases.

Qin Xingqiang said that at present, the average reporting time of China’s infectious disease network direct reporting system has been shortened from five days to four hours now. At the national level, a technical system for rapid identification of 300 pathogens within 72 hours has been established, and 100% of provincial and 90% of municipal CDC have the ability to detect nucleic acids and isolate viruses. In the prevention and control of major infectious diseases, the rapid rise of AIDS epidemic in key areas has been effectively curbed; The mortality rate of tuberculosis remains at a low level; All endemic counties of schistosomiasis have reached the state of transmission interruption; Measles, Japanese encephalitis and other vaccines can prevent the incidence of infectious diseases from falling to the lowest level in history.

Construction of 321 high-level key disciplines of traditional Chinese medicine

In order to promote the development of China’s traditional Chinese medicine service system, Ouyang Bo, deputy director of the Comprehensive Department of the State Administration of Traditional Chinese Medicine, introduced that the State Administration of Traditional Chinese Medicine, the National Health and Wellness Commission and the National Development and Reform Commission took the lead in establishing an inter-departmental working mechanism with relevant departments, and the central government invested nearly 13 billion yuan to promote key tasks and major engineering projects to basically achieve "double half".

Ouyang Bo said that China’s traditional Chinese medicine inheritance and innovation has been steadily promoted-46 national traditional Chinese medicine inheritance and innovation centers have been built, and 50 superior diseases treated by traditional Chinese medicine, 52 integrated Chinese and Western medicine diagnosis and treatment programs, 100 appropriate technologies and 100 Chinese medicine varieties with unique curative effects have been selected and released. The official publication of the first batch of 74 books in the "Chinese Medical Collection" marks a major stage achievement in the compilation of ancient Chinese medicine books.

At the same time, the team of talents with Chinese medicine characteristics has been growing, training 50 Qihuang scholars, 500 national outstanding clinical talents of Chinese medicine, 100 young Qihuang scholars, 35 innovative teams of Chinese medicine, and building 321 high-level key disciplines of Chinese medicine.

According to preliminary estimates, in 2023, the total number of medical treatment in Chinese medical and health institutions was 1.28 billion, and the number of discharged patients was 41.486 million. Chinese medicine played an active role in serving people’s health.

Building a high-quality and efficient Chinese medicine service system is one of the main tasks of the development plan of Chinese medicine in the 14 th Five-Year Plan. In this regard, Ouyang Bo said that the State Administration of Traditional Chinese Medicine aims to achieve high-quality Chinese medicine services for everyone nearby, promote 14 Chinese medicine hospitals to be included in the founding unit of the National Medical Center, lay out and build 27 national regional medical centers for Chinese medicine, and continue to promote the construction of 62 "flagship" hospitals and 138 key hospitals with Chinese medicine characteristics. At the same time, optimize the supply of Chinese medicine services, select about 1,000 national traditional Chinese medicine specialties and 500 "flagship" departments for the coordination of Chinese and Western medicine, determine 31 units for the construction of Chinese medicine rehabilitation centers, strengthen the construction of pediatrics and geriatrics departments in Chinese medicine hospitals, and promote the construction of outpatient clinics for Chinese medicine specialties; Taking the construction of county-level Chinese medicine hospitals as the leader, we will build a solid grassroots network, promote tertiary hospitals to help 699 county-level Chinese medicine hospitals, and achieve full coverage of grassroots Chinese medicine museums in 23 provinces, so as to facilitate the masses to take a good look at Chinese medicine at their doorsteps.(Reporter Jin Zhenya)

More than 8 models of Tiggo were exposed to brake failure, and the problem pointed to brake by wire!

If you are the owner and prospective owner of Tiggo 8 PRO or Tiggo 8 PLUS, please note that there is something wrong with Chery’s brake-by-wire technology.

Recently, Master Jiao learned from relevant channels that Chery’s brake-by-wire technology has brought troubles to many car owners. The specific performance is as follows: 1. There will be a buzzer when braking; 2. The brake pedal becomes hard; 3. Brake failure; 4. Brake jitter. At present, it is understood that some car owners have formed rights protection groups and shared fault cases in the groups.

Please step on the brakes when the vehicle starts, but the owner has been stepping on the brakes.

The corner master found that a car owner was driving at a low speed of 30 kilometers per hour, and suddenly the brake pedal rebounded, and then a fault code appeared in the dashboard. At this time, the brake pedal felt hard and the hard-vegetable pedal vehicle appeared jitter.

At present, the official has not responded to this problem, and the owner has locked the root of the problem in the brake-by-wire technology. Because some owners of Tiggo 8 PRO and Tiggo 8 PLUS do not have such problems, the problem owners are mainly concentrated in the vast version of Tiggo 8 PRO and Tiggo 8 PLUS pride+,so what is Chery’s brake-by-wire technology?

In March 2022, Chery Automobile announced a major innovation when it launched the Tiggo 8 PLUS version. The braking system of the car was upgraded and the integrated brake-by-wire system of Bethel WCBS was adopted. The core technology of this system is to integrate the vacuum booster pump, master cylinder, electronic vacuum pump, EPB and ESC. The following figure shows the comparison between the integrated brake-by-wire system module and the traditional vacuum booster pump. Its main purpose is to reduce costs and enhance the competitiveness of products. In addition to cost reduction, the official said that this system can also coordinate energy recovery system and high dynamic pressurization capacity. In other words, most of Chery’s new energy vehicles will adopt the brake-by-wire system in the future.

Integrated brake-by-wire system

Traditional vacuum booster pump

However, at present, it is obvious that the technology is not yet mature, and some car owners equipped with brake-by-wire technology have become "mice". Master Jiao then went to the domestic third-party vehicle quality complaint platform to investigate and found that there have been centralized complaints about the models equipped with brake-by-wire technology in the Tiggo 8 PRO plate, and the most complained car in the Tiggo 8 PLUS plate is Haoqing+,which is also equipped with brake-by-wire technology.

Up to now, Chery officials have not responded to the vehicles with problems in the by-wire control technology. Judging from the problem of concentrated outbreak, Master Jiao’s personal guess may be that there is a problem with a batch of vehicles equipped with wire control technology. The failure of the brake system is a major personal safety hazard, and the manufacturer must attach great importance to it, and it is necessary to complete the upgrade, optimization and even recall of the problem model in a short time.

A few days ago, Chery Automobile just released the sales data in July 2022, and the group’s sales volume was 131,533, a year-on-year increase of 57.7%. This figure successfully surpassed 122,633 vehicles of Geely Automobile and 101,920 vehicles of Great Wall Motor. In terms of splitting, Chery’s total sales volume was 131,533 vehicles, of which 50,614 vehicles were exported, up 90.1% year-on-year. The sales volume of new energy was 25,614 vehicles, a year-on-year increase of 253%. It can be seen that the sales of new energy have surged, and in addition, the export volume has reached a new high. This is the happy side.

However, the safety hazard brought by the brake-by-wire technology hangs over Chery like a time bomb. However, if it is detonated, it will surely face the collapse of product quality reputation, and all efforts will be wasted.

Hebei： The two forecasting services are as accurate and timely.

　　China Meteorological News correspondent Xie Pan Li Haiqing

　　After entering July, the rain came one after another, which put Hebei meteorological disaster prevention and mitigation mechanism to the test and made people constantly think about the construction of disaster prevention and mitigation mechanism.

　　Department linkage makes flooding invisible.

　　"The’ July 21′ precipitation was the biggest since the establishment of the meteorological observatory in Zhuozhou in 1957, but it realized the miracle that no one was killed or injured. The meteorological disaster prevention mechanism led by the government, departmental linkage and social participation played a decisive role. " Liu Yingfeng, director of the Zhuozhou Meteorological Bureau, said.

　　Zhuozhou Flood Control and Drought Relief Headquarters was built in the Municipal Meteorological Bureau. Through information cooperation and resource sharing, with the goal of preventing severe floods, fighting severe droughts and grabbing major risks, Zhuozhou actively built a modern and information-based flood control and drought relief command platform, and built five systems, namely decision-making command, video consultation, real-time monitoring, early warning release and logistics support.

　　On July 19th and 20th, Zhuozhou Meteorological Bureau sent important precipitation weather report information to more than 120 leaders of municipal party committee, municipal government, 15 townships, offices and development zones and 29 related departments such as flood control and meteorological disaster prevention through the early warning release system.

　　On the afternoon of 21st, at the beginning of precipitation, Wang Zhou, secretary of the municipal party committee and political commissar of the flood control and drought relief headquarters, and Zhu Ziqiang, mayor and commander of the flood control and drought relief headquarters, rushed to the flood control and drought relief headquarters at the first time and quickly entered an emergency state.

　　At 3 am on the 22nd, the precipitation ended. No one was killed or injured in 69 villages in Zhuozhou flood detention area. "When the’ July 21′ torrential rain occurred, Baoding’s practices of accurate forecasting, timely warning and rapid transfer of people played an important role and were successful experiences in effectively coping with disasters." Zhang Qingwei, deputy secretary of Hebei Provincial Party Committee and governor, spoke highly of it.

　　
　　Internal and external training makes the prevention more detailed.

　　From July 27th to 29th, strong precipitation hit most of Hebei again. On the evening of 27th, Li Xingwen, director of Chengde Meteorological Bureau, closely monitored the weather changes with the personnel on duty, and provided rolling rain warning service to the government, flood control, information officers and relevant departments according to the rainstorm monitoring system.

　　From the evening of 28th, the strong convective weather in Tangshan began to strengthen. At 2100 hours, more than 50 mm of precipitation occurred in the northern part of Tangshan, reaching 100 mm in some areas. The Tangshan Meteorological Observatory issued an orange rainstorm warning signal.

　　In Qinhuangdao, Liu Jian, director of the Municipal Meteorological Bureau, requested that during the precipitation process, the meteorological department release the latest rainfall situation, the weather forecast for the next two hours and the short-term weather forecast for the next 24 hours every hour, and report them to the command center of the Municipal Flood Control Office by fax, email and SMS.

　　Late at night on the 28th, heavy precipitation gradually stopped. Shen Xiaoping, deputy governor of Hebei Province, was pleased to say to Yao Xuexiang, director of the Provincial Meteorological Bureau: "These two forecasts are as wonderful as meteorological services!"

　　Since 2010, disaster prevention has been more targeted through the implementation of "process reengineering" project, detailed disaster prevention process, timely consultation and communication, real-time monitoring of rain conditions and disasters, normal operation of regional automatic stations, and close cooperation between meteorological information personnel, assistants and meteorological disaster prevention responsible persons.

　　Eliminating difficulties in popular science and making defense more effective

　　A rainstorm makes people pay more attention to meteorological forecast and early warning, and at the same time, how to prevent meteorological disasters in production and life has become a topic of public concern.

　　"While strengthening meteorological forecasting and early warning, we must do a good job in popular science propaganda, so that the people can understand the forecasting and early warning signals and take precautions in time." On 25th, Zhang Qingli, secretary of the Hebei Provincial Party Committee and director of the Standing Committee of the Provincial People’s Congress, and other leaders made it clear when they inspected the disaster situation in Laishui.

　　"At present, Hebei has entered the peak season, and strong convective weather such as short-term heavy rain and lightning frequently occurs. Here, we will explain the rainstorm warning signal and the way to get the warning signal in detail." A Weibo was posted in time by "Hebei Weather", and fans scrambled to reprint it.

　　On the Hebei Weather Network, the contents of rainstorm warning signal interpretation, risk avoidance and self-help measures are added, which are linked with local mainstream media to let more people know.

　　On the 27th, Zhang Qingwei, vice governors Song Enhua and Shen Xiaoping called Yao Xuexiang, director of the Provincial Meteorological Bureau, respectively: the release of meteorological early warning information has been greatly improved in terms of frequency, content and coverage, and a series of effective measures have been taken to publicize meteorological science knowledge in response to heavy rain, which further enhanced the pertinence and effectiveness of services, and fully understood and implemented the requirements and deployment of the provincial party committee and government on this work.

　　Promoting performance management and exploring the source of consolidation

　　From July 20 to 28, heavy precipitation occurred frequently in Hebei, and the rainfall of several rainfall stations exceeded 200 mm, causing serious economic losses to some areas.

　　How to avoid or reduce the losses caused by meteorological disasters more effectively? How to improve the fortification ability of remote rural areas, so that the tragedy of urban disaster risk reduction and people trapped in floods can not save themselves will not be staged again?

　　Taking performance management as the starting point, Hebei Province has continuously improved the meteorological disaster prevention mechanism led by the government, coordinated by departments and participated by the society, so as to improve the level of meteorological disaster prevention.

　　State Council document No.33 pointed out that it is necessary to strengthen monitoring and early warning from the government and relevant departments of disaster prevention and mitigation, and continuously improve the accuracy of forecasting; Establish a wide coverage and rapid meteorological early warning information distribution network; Form an effective emergency linkage of meteorological disaster prevention and mitigation.

　　"To carry out performance management of meteorological disaster prevention and mitigation is to improve the ability of meteorological disaster prevention and eliminate potential safety hazards." This is the feeling that Liu Yuhu, director of Baoding Meteorological Bureau, promoted this work.

　　(Editor: Sun Wei)

Flora, the health guard in the intestine

There are more than 10 trillion huge microbial groups in human skin and intestines, and their number is more than 10 times of the total number of human cells, which is considered as another set of genomes besides human cells. Under normal circumstances, the vast majority of bacteria in the gastrointestinal tract are beneficial to the human body, but due to various factors, the intestinal flora will also be unbalanced, and once it is unbalanced, it is easy to induce various chronic diseases.

The second organ of the human body

We collectively refer to the bacteria living in the intestine as intestinal flora. Their total weight in the human body is 2~3 kg, and there are more than 1,000 species. More than 50% of the feces we excrete every day are composed of these bacteria and their corpses. These small bacteria are symbiotic with our human body. They are rooted in the intestine for a long time to maintain our health, so we also call the intestinal flora "the second organ of the human body".

First of all, intestinal flora can shield and influence the immune system by itself, and prevent pathogenic bacteria from invading the human body. Intestinal flora adheres to the mucosal layer on the surface of the inner wall of the intestine, forming a barrier composed of bacteria. Intestinal flora inhibits the growth of pathogenic bacteria through the dominant symbiotic bacteria activities, and prevents pathogenic bacteria from entering the human body through this barrier. At the same time of passive defense, intestinal flora can stimulate the body to form more lymphatic organs in the intestine, and increase the level of immunoglobulin in plasma and intestinal mucosa, so that the immune system is in a moderately active state, so as to maintain an effective immune effect on invading pathogens.

In addition, intestinal flora has regulating and nutritional effects on the intestine. It has been reported that the existence of intestinal flora, especially the nutritional function of short-chain fatty acids produced by it, can make the growth of intestinal epithelial cells more active. In addition, intestinal flora can also regulate the differentiation of intestinal mucosal epithelial cells. This means that with normal intestinal flora, intestinal mucosa can be repaired more quickly.

Recent studies have shown that intestinal flora has an important relationship with human metabolic diseases. In addition, there are many other relationships between intestinal flora and health. Carotenoids produced by intestinal flora can reduce the risk of atherosclerosis and stroke to some extent. Normal intestinal flora can regulate the body’s response to allergens through the influence on lymphocytes, thus affecting the occurrence of allergic diseases. Even more surprising, there is evidence that the structural changes of intestinal flora can even affect the behavior patterns of the body.

Bacteria are also divided into good and bad

"Bacteria exceeded the standard" and "food was found to have bacteria" … People often talk about "bacteria" discoloration, but they don’t know that bacteria are also good or bad. Microbial communities are constantly influenced by many factors in the process of growth, including heredity, age, gender, diet and lifestyle. Everyone’s intestinal microbes have their own characteristics, but in healthy individuals, the relative abundance and distribution of bacterial species are very similar, and they all play a role in maintaining people’s overall health. There are "beneficial bacteria" that provide positive energy, "harmful bacteria" that love to make trouble, and some originally harmless bacteria that may take advantage of the situation and cause harm to the body. Such bacteria are called "opportunistic pathogens" or "conditional pathogens".

The normal flora of gastrointestinal tract can be divided into aerobic bacteria, facultative anaerobic bacteria and anaerobic bacteria. The most dominant is anaerobic bacteria, accounting for 99% of the total flora. The types and quantities of bacteria in the stomach, duodenum and jejunum are less, and the bacteria in the ileum begin to increase. In the colon, the types and quantities of bacteria increase more significantly, most of which are anaerobic bacteria, and Bifidobacterium, Bacteroides and Lactobacillus are absolutely dominant, while Clostridium and Staphylococcus, which are potentially pathogenic, account for only a few.

The imbalance of flora leads to many diseases.

If the intestinal flora is out of balance, health will go wrong. When beneficial bacteria can’t compete with harmful bacteria or conditional pathogens, they show bacterial infection, and symptoms of gastrointestinal diseases such as diarrhea, abdominal pain, vomiting and fever appear. For example, the endotoxin produced by the imbalance of intestinal flora will increase the burden of liver detoxification and cause liver damage. These toxins will also enter our brain, causing abnormal brain development, causing autism, depression, Alzheimer’s disease and other symptoms. In addition, the imbalance of intestinal flora will also lead to cardiovascular and cerebrovascular diseases such as atherosclerosis.

There are five main reasons for the imbalance of intestinal flora: 1. Long-term unbalanced diet. For example, eating too much meat or vegetables and eating unhealthy food for a long time; 2. Ingestion of food contaminated by bacteria. Reduce resistance, make conditional pathogens "worse", or ingest too many harmful bacteria, imbalance of intestinal flora, and diarrhea symptoms; 3. Age increases. With the increase of age, some beneficial bacteria decrease and harmful bacteria increase, and the body’s immunity weakens; 4. Use certain drugs. Excessive use of antibiotics leads to imbalance of intestinal flora and decreased immunity; 5. Gastrointestinal dysfunction. Organic causes lead to imbalance of intestinal flora and decreased immunity.

Diet regulation is safe and effective.

Now we have a safe, effective and scientific conditioning method, that is, taking microecological preparations. This preparation mainly includes three types, namely probiotics, prebiotics and synbiotics. Probiotics contain a certain number of live bacteria preparations; Prebiotics can promote the growth of intestinal probiotics; Synbiotics is a mixture of probiotics and prebiotics, which can not only supplement the probiotics in our body, but also promote the growth of probiotics.

Yogurt is a good choice to supplement probiotics. It contains plenty of protein, and also contains Lactobacillus bulgaricus and Streptococcus thermophilus, but these two kinds of bacteria can’t colonize in our intestines, and yogurt at room temperature contains no live bacteria.

In addition to yogurt, there are many lactic acid bacteria drinks on the market at present. This kind of drink has a very high sugar content, and its nutritional value is relatively low compared with yogurt. Moreover, most of these drinks are stored at room temperature, so it does not contain live bacteria.

There is also an active lactic acid bacteria beverage, which requires strict cold chain transportation and cold storage. However, for people with gastrointestinal discomfort, drinking cold drinks often stimulates the intestines, and there is no way to guarantee the probiotic activity contained in such drinks.

In addition, bad eating habits will destroy the balance of intestinal flora, for example, a high-fat diet will change the intestinal flora. Adjusting the dietary structure and developing good eating habits play an important role in maintaining the dynamic balance of intestinal flora.

Intestinal flora changes with age, and some studies show that the number of bifidobacteria in the intestine of the elderly is significantly reduced. Therefore, in the diseases related to intestinal flora imbalance in the elderly, proper application of microecological agents is conducive to the recovery of the health of the elderly.

Commonly used microecological agents include live bacterial agents such as Bifidobacterium, Lactobacillus and Enterococcus. Increasing the number of beneficial bacteria can not only regulate the balance of intestinal flora, but also enhance the immunity of the body. ▲ (This lecture was written by Cui Yuyan, a special correspondent of this newspaper)

China food and drug administration issued the Measures for the Administration of Food Recall.

In order to implement the first responsibility for food safety of food producers and operators, strengthen food safety supervision, and ensure public health and life safety, on February 9, 2015, the china food and drug administration executive meeting deliberated and adopted the Measures for the Administration of Food Recall. On March 11th, Director Bi Jingquan of china food and drug administration signed Order No.12, which will be implemented on September 1st, 2015.

　　China food and drug administration conscientiously implements the spirit of the Fourth Plenary Session of the 18th CPC Central Committee, adheres to scientific and democratic legislation, and strives to improve the quality of legislation. On the basis of fully absorbing and drawing lessons from useful experience at home and abroad, after extensive investigation and repeated argumentation, the Measures for the Administration of Food Recall was formed. The main contents include:

　　First, strengthen the prevention and control of food safety risks.First, if unsafe food is found in the process of production and operation, the food producers and operators shall immediately stop production and operation; If the products have entered the market, the food producers and operators shall recall the unsafe food in strict accordance with the time limit, and inform the relevant food producers and operators to stop production and operation and consumers to stop eating, and take necessary measures to prevent and control food safety risks. Second, if the promoters of centralized food trading markets, lessors of food counters, organizers of food fairs and providers of third-party platforms for online food trading find unsafe food, they should take effective measures in time to ensure that relevant operators stop operating unsafe food. The third is to standardize the recall time limit of food producers and operators. If the first-level recall has caused or may cause serious health damage or even death after eating, it shall be started within 24 hours after knowing the food safety risks and completed within 10 working days; If the second-level recall has caused or may cause general health damage after eating, it should be started within 48 hours after knowing the food safety risks and completed within 20 working days; Three-level recall refers to the food with false labels and labels, which should be started within 72 hours after knowing the relevant food safety risks and completed within 30 working days. Fourth, unsafe foods such as illegal addition of non-edible substances, corruption, sick and dead livestock and poultry, which seriously endanger human health and life safety, should be immediately destroyed on the spot.

　　Second, strengthen the implementation of corporate responsibility.The first is to clarify the main obligations. Food producers and business operators shall assume the obligation of being the first person responsible for food safety, and perform the responsibilities of stopping production, operation, recall and disposal of unsafe food according to law. The second is to standardize the announcement. Food producers and business operators shall publish unsafe food recall notices on the websites of food and drug supervision departments at or above the provincial level and major media. The third is a strict written report. If there is a great food safety risk in unsafe food, food producers and operators shall report in writing to the food and drug supervision department within 5 working days after stopping production and operation, recalling and disposing of unsafe food. The fourth is to standardize information recording. Food producers and business operators shall truthfully record the names, trademarks, specifications, production dates, batches, quantities and other contents of unsafe foods that have stopped production and operation, recalled and disposed of. The record retention period shall not be less than 2 years. The fifth is to strengthen accountability. Legal responsibilities have been set for acts such as not stopping production and operation immediately, not taking the initiative to recall, not starting the recall within the prescribed time limit, not recalling unsafe food according to the recall plan or not disposing of unsafe food according to regulations. While strengthening the main responsibility of food producers and operators, it is also stipulated that if food producers and operators take the initiative to stop production and operation, recall and dispose of unsafe food to eliminate or mitigate the harmful consequences, they will be given a lighter or mitigated punishment according to law; If the illegal circumstances are minor and corrected in time, and no harmful consequences are caused, no administrative punishment shall be imposed.

　　Third, strengthen strict supervision according to law.First, it is ordered to perform according to law. If a food producer or operator fails to stop production and operation, recall and dispose of unsafe food according to law, the food and drug supervision department at or above the county level may order him to fulfill the above obligations. The second is to issue early warning information. In order to effectively prevent and control risks, the food and drug supervision department can issue early warning information, require relevant food producers and operators to stop producing and operating unsafe food, and prompt consumers to stop eating. The third is on-site supervision and inspection. The food and drug supervision department may conduct on-site supervision and inspection on the situation that food producers and operators stop production and operation, recall and dispose of unsafe food. The fourth is to carry out effect evaluation. The food and drug supervision department may evaluate the reports submitted by food producers and operators on the cessation of production, operation, recall and disposal of unsafe food. If the evaluation conclusion is that the measures taken by food producers and operators are not enough to control food safety risks, the food and drug supervision department shall order food producers and operators to take more effective measures to stop production and operation, recall and dispose of unsafe food. The food and drug supervision department shall organize the establishment of a food safety expert database to provide professional support for the cessation of production, operation, recall and disposal of unsafe food. The fifth is to strengthen the implementation of responsibilities. If the food and drug supervision department fails to perform its duties according to law, resulting in adverse consequences, administrative sanctions shall be imposed on the directly responsible person in charge and other directly responsible personnel according to law.

　　China food and drug administration requires local food and drug supervision departments to conscientiously publicize and implement the Measures for the Administration of Food Recall, further standardize the work of stopping production, operation, recall and disposal of unsafe food, continuously improve the ability and level of food safety supervision, effectively prevent and control food safety risks, and ensure public food safety.

Scientific and technological innovation leads high-quality development

　　Innovation is the first driving force for development. In 2021, scientific and technological innovation will support and lead the high-quality development of China’s economy.

　　In recent years, the global economy has been hit by the COVID-19 epidemic, but China’s economy has maintained a growth trend. In 2021, China’s innovation-driven development trend continued to improve, the profit growth rate and investment growth rate of high-tech industries maintained a high level, and the transformation of old and new kinetic energy was accelerated during the epidemic.

　　The economic growth of national high-tech zones is good.

　　National High-tech Zone has become an important strategic support and new growth point of China’s economy. From January to August this year, 169 national high-tech zones realized an operating income of 29.5 trillion yuan, a year-on-year increase of 21.9%; The total profit was 2.3 trillion yuan, a year-on-year increase of 36.8%; The total export volume was 3.0 trillion yuan, a year-on-year increase of 25.4%; The profit rate of national high-tech zone enterprises’ operating income was 7.8%, an increase of 0.9 percentage points over the same period of last year; The number of newly registered enterprises in the National High-tech Zone was 436,000, a year-on-year increase of 34.1%.

　　"These data show that the national high-tech zone economy has maintained a good growth momentum and innovation and entrepreneurship have continued to be active." Jia Jingdun, director of the Torch Center of the Ministry of Science and Technology, said.

　　The performance of high-tech zones such as Zhongguancun in Beijing and Donghu in Wuhan is quite outstanding. From January to August, the technology income of Zhongguancun Science Park was 996.68 billion yuan, up 26.3% year-on-year, and the sales income of new products was 592.58 billion yuan, up 96.0% year-on-year. Together, they accounted for about 30% of the total income, and the income structure continued to be optimized. The profit rate of the enterprise was 10.5%, 1.6 times that of the same period of last year. From January to August, the leading industries in Wuhan Donghu High-tech Zone continued to develop strongly, and the industrial output value of optoelectronic information industry reached 125.52 billion yuan, a year-on-year increase of 40.2%.

　　High-tech Zone solves problems for enterprises in the park and optimizes various services.

　　"Haidian Pioneer Park has solved the financing problem of enterprises, and the service has achieved results and the amount has reached a new high." Zhao Xinliang, director of in haidian estate of zhongguancun science park Innovation Service Center, introduced that Haidian Pioneer Park has classified and integrated the resources of more than 800 high-quality cooperative institutions, effectively linked financing needs and reduced corporate financing costs. In 2021, 9 financing docking activities have been held, including the "three or three meetings" and investor meetings, with 180 sub-enterprises and more than 600 sub-investment institutions participating. They also joined the Beijing Equity Exchange Center to recommend 240 high-quality enterprises to land on the "four boards" for free, helping enterprises to standardize their operations and enter the multi-level capital market.

　　High-tech zones actively responded to the requirements of self-reliance and self-improvement in science and technology, and launched a number of reforms.

　　The "Minshan Action" plan is a special practice launched by Chengdu High-tech Zone this year. It is based on the actual ability and effectiveness of solving the problem of "sticking the neck" in industrial development. After the release of the first demand list, 92 application teams were attracted, including 18 academicians leading the team. At present, six new R&D institutions, including Chengdu Minshan Institute of Hydrogen Energy and Carbon Neutralization Technology and Chengdu Minshan Institute of Power Semiconductor Technology, have successfully unveiled the list and obtained support funds of about 450 million yuan.

　　"The team that successfully unveiled the list needs to sign the task book for unveiling the list and set up ‘ Military order ’ , according to the established goals and ‘ Milestone ’ Node to attack, and take ‘ Assessment once a year, elimination once every three years ’ Management methods, timely suspension of non-performance or poor progress of the project. " Wang Xiaoning, deputy director of Chengdu Hi-tech Zone Science and Technology Talent Bureau, said.

　　High-tech enterprises operate efficiently

　　High-tech enterprise groups have gradually become the main force of scientific and technological innovation. At present, there are 278,000 high-tech enterprises in China, accounting for only 0.6% of the total number of enterprises in the country, but the R&D expenditure is as high as 1.33 trillion yuan, exceeding 70% of the R&D expenditure of enterprises in the country.

　　Some high-tech leading enterprises aim at the future and increase investment.

　　At the Guangzhou Auto Show on November 18th, Iflytek Smart Car unveiled many intelligent interactive products, and officially released a set of "Flying Fish Intelligent Audio Management System". Advanced sound algorithms such as 3D immersion surround sound with independent intellectual property rights can instantly restore audio with high quality, bringing users a richer and fuller listening experience.

　　"The automobile has a long industrial chain and high technical complexity. In the context of the Internet of Everything, the automobile has become one of the main battlefields for the application of artificial intelligence." Wu Xiaoru, president of Iflytek, said that at present, Iflytek is making joint efforts from many aspects, such as intelligent interaction, intelligent service and intelligent sound field, to help the automobile industry upgrade in an all-round way.

　　With the rise of a new round of scientific and technological revolution and industrial transformation, the global intelligent networked automobile industry has ushered in a new major historical development opportunity. Iflytek has been deeply involved in the automobile field for 18 years, and delivered more than 1,000 models, with a front-mounted capacity of over 31 million and an annual installed capacity of over 6 million.

　　Some traditional industrial enterprises use technology to drive transformation and upgrading.

　　Xin ‘an Chemical is a leading enterprise in glyphosate production industry in China. In view of the widespread phenomenon of "flue gas tailing" in the industry, Xin’ an Chemical has stepped up scientific and technological research and pioneered the "deep treatment technology of directional conversion flue gas" nationwide; More than 20 million yuan was invested in six new projects of tail gas treatment technology after the production of glyphosate by-product crude phosphate. The flue gas treatment system of directional conversion unit realized the upgrading of the process and the upgrading of environmental protection devices.

　　Yu Meidong, director of phosphate plant in Xin ‘an Chemical Industry, introduced that the technology deeply treated the directional conversion flue gas and realized the ultra-low emission of tail gas from chemical production. "We believe that the enterprises that take the lead in bid upgrading can gain market opportunities and realize transformation and development."

　　High-quality input brings high-quality output. According to the statistics of China National Intellectual Property Administration, by the end of September 2021, high-tech enterprises had 5.617 million valid patents, an increase of 15.8% over the same period of last year, including 1.127 million valid invention patents, an increase of 20.1% over the same period of last year.

　　The cultivation and development of high-tech enterprises has become an important starting point for all localities to promote high-quality economic development. According to statistics, from January to August this year, the number of industrial high-tech enterprises in China exceeded 101,000, accounting for 25.1% of the total industrial enterprises in China, with 37.3% of the total assets, achieving 33.4% of operating income and 40.3% of total profits.

　　"In the first three quarters, high-tech enterprises generally operated well, and the benefit indicators were generally better than the national level." Jia Jingdun said.

　　The vitality of innovation and entrepreneurship continues to be released.

　　In 2021, China’s "double innovation" vitality continued in generate, and its innovation and entrepreneurship continued to upgrade. Scientific research institutions took the initiative to connect with the market, and the total transaction volume of technology contracts increased significantly.

　　In recent years, the Institute of Microbiology of China Academy of Sciences has made outstanding achievements in the fields of recombination vaccines in COVID-19, therapeutic antibodies, low-carbon intellectual production in polyamide industry and cultivation of innovative crop varieties with disease resistance, resulting in a market value of over 100 billion yuan. Qian Wei, director of the Institute, said that the Institute’s major needs and goals lead to basic research, and in the core innovation fields such as "microbial frontier", "life and health" and "green and low-carbon sustainable development", it has established an efficient linkage mechanism with "innovation chain driving the industrial chain", focused on major tasks and objectives, and solved outstanding problems in reality with modern biotechnology such as modern vaccines, gene editing, synthetic organisms and microbiome as sharp edges.

　　"The Torch Center will speed up the improvement of the market-oriented allocation system and mechanism of technical factors, and continuously open the channels for technical factors to enter the economic system and industrial system." Jia Jingdun introduced that as of September 20, 2021, a total of 347,748 technology contracts were registered, with a turnover of 2,071.98 billion yuan, up 33.4% and 45.6% respectively, and the total transaction volume of technology contracts continued to grow.

　　The service capacity of scientific and technological innovation carriers has been continuously improved, helping enterprises tide over the epidemic situation.

　　In the first three quarters of this year, there were 46,000 creative teams of 1,692 creative space services submitted by 2,251 countries for record, and the total rent reduction for entrepreneurial teams and start-ups was 210 million yuan; Among the 1,287 state-level science and technology business incubators, 91,000 enterprises are incubating in 1,093 incubators, and the total rent reduction for incubating enterprises is 370 million yuan; Among the 139 national university science parks, 103 submitted statistics reduced or exempted the rent by 38.067 million yuan for incubating enterprises.

　　Yang Bin, president of China Science and Technology Development Institute, said that up to now, the incubation system of China Development Institute has operated 30 incubation carriers nationwide, with 1,815 incubating enterprises and 1,164 graduated enterprises. "After the outbreak of the COVID-19 epidemic, in order to cope with the operational difficulties of small and medium-sized enterprises, the China Development Institute actively responded to national policies. The Shenzhen Incubation Base and the national holding bases successively reduced the rent and incubation service fees for small and medium-sized technology enterprises, reaching 17 million yuan."

　　Science and technology enterprises have received continuous support from financial institutions, and technology stocks have increasingly become the main force in the capital market.

　　According to statistics, by the end of August, 51.1% of high-tech enterprises had received loan support from financial institutions, and the number of high-tech enterprises that received loan support increased by 5,655 compared with the beginning of the year; The loan balance of 142,000 high-tech enterprises was 8,868.77 billion yuan, with an average loan support of 62.466 million yuan for each enterprise; The loan rate of small and medium-sized science and technology enterprises was 42.9%, and the number of enterprises supported by loans increased by 5,723 compared with the beginning of the year, and the accumulated loan amount exceeded 1 trillion yuan.

　　By the end of September, 43.9% and 50.2% of high-tech enterprises had publicly issued shares on the main board of Shanghai Stock Exchange and Shenzhen Stock Exchange, and 95.0% and 87.1% had publicly issued shares on the Growth Enterprise Market of science and technology innovation board Stock Exchange and Shenzhen Stock Exchange. (Economic Daily reporter She Huimin)

It takes only 4 minutes to replace the heavy truck with the power station.

Recently, the new energy heavy truck power station located in Tiexinqiao service area of Ring Expressway was officially put into use. It only takes 4 minutes for a vehicle to change power once, and it can serve a variety of heavy truck models, such as muck trucks, mixing tankers, tractors, etc., and realize the sharing of power change between different models. The picture shows that the new energy truck was changing electricity at the new energy heavy truck power station in Tiexinqiao service area yesterday. Nanjing Daily/Purple Mountain News reporter Feng Weishe

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