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Analysis and Prospect of Global Pharmaceutical Market in 2017-2022

I. Market size and growth rate

the year 2017The global prescription drug market size is$774 billion, estimated from 2017 to 2022.The annual growth rate of CAGR is 6.5%By 2022, the prescription drug market will exceed the trillion-dollar level for the first time, reaching$1.06 trillion. CAGR exceeds that in the field of instruments5.1%.

Prescription drug market is divided intoPrescription drugs (except generic drugs and Orphan drugs), generic drugs and orphan drugs.Three market segments. Among them,generic drugsIn 2017-2022, the scale of the overall prescription drug market will be10%-11%The annual growth rate of CAGR is slightly lower than that of the overall prescription drug market.6.0%The market scale will be from 2017.$84 billionGrowing to 2022$112 billion; Annual growth rate of orphan drugs in 2017-2022CAGR was 11.2%, a rare double-digit growth, the market size will be from 2017.$123 billionrise to$209 billion, accounting for the overall prescription drug market size will be from15.9% in 2017rise to19.7% in 2022.

Although the expected market share can be increased, in fact, the proportion will remain basically unchanged in the next five years; The proportion of orphan drugs has steadily increased.

2. What is the impact of the patent cliff?

It is expected to be from 2017 to 2022.$194 billionThe drug market is facingPatent cliff patent cliffThe challenge is mainly due toBiosimilar, a biosimilarIn the previous article, I also shared the market of Biosimilar, the global biosimilar market and competition analysis |Q said. This patent cliff may be fromThe first patent cliff in 2012After the second patent cliff peak.

Of course, there are still some variables in the future who will eat this big cake in the generic drug market. In addition to companies that focus on generic drugs,Big pharmaceutical companiesNow I have also found a way. If my patented drug expires, I can authorize it to be authorized generics, which is exactly the same as the original patented drug, except that the trademark is removed and the price is lower, and the regulatory authorities do not have to work hard to approve it. Regarding the definition of Authorized Generics, FDA gives the following explanation.

The term “authorized generic” drug is most commonly used to describe an　approved brand name drug that is marketed without the brand name on its label. Other than the fact that it does not have the brand name on its label, it is the　exact same drug product as the branded product.An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. In some cases, even though it is the same as the brand name product, a company may choose to sell the authorized generic　at a lower cost　than the brand name drug.

Many big pharmaceutical companies have begun to plan this.Instead of letting others eat the cake, it is better to distribute it yourself or share it with others.; The time and method of specific sales are also controllable; Why not?

III. What are the hot treatment areas?　

fromFrom the perspective of Biotech, a biological medicine, and Conventional medicine, Conventionality.Look, 2017-2022Biological medicineThe proportion of the overall market has steadily increased and tends to be flat, and will be from26% in 2017 increased to 30% in 2022.; At the same time, biopharmaceutical head productsTop 100 productsThe proportion of total biopharmaceuticals is from 2016.49%Increased to 202252%.

fromTreatment areaLooking at it, the following ten areas have the largest market scale.

（1）Oncology of tumorIt is still the largest market segment, with CAGR in 2016-2022.12.7%Will reach in 2022.$192.2 billionSales, accounting for global market share17.5%.

（2）Diabetes Anti-diabeticsIt is the second largest market segment, with CAGR in 2016-2022.4.8%Will reach in 2022.$57.9 billionSales, accounting for global market share5.3%.

（3）Rheumatism Anti-rheumaticsIt is the third largest market segment, with CAGR in 2016-2022.0.6%Will reach in 2022.$55.4 billionSales, accounting for global market share5.0%.

（4）be antiviralAnti-virusIt is the fourth largest market segment, with CAGR in 2016-2022.-2.1%Will reach in 2022.428Billion dollarsSales, accounting for global market share3.9%. fornegative growthSo Gilead is nervous.

（5）Vaccine VaccinesIt is the fifth largest market segment, with CAGR in 2016-2022.4.2%Will reach in 2022.353Billion dollarsSales, accounting for global market share3.2%.

（6）Bronchodilators of respiratory system bronchusIt is the sixth largest market segment, with CAGR in 2016-2022.1.0%Will reach in 2022.301Billion dollarsSales, accounting for global market share2.7%.

（7）Sensory organsIt is the seventh largest market segment, with CAGR in 2016-2022.five.8%Will reach in 2022.283Billion dollarsSales, accounting for global market share2.6%.

（8）Immunosuppressant ImmunosuppresantsIt is the eighth largest market segment, and the CAGR in 2016-2022 is14.6%Will reach in 2022.263Billion dollarsSales, accounting for global market share2.4%. This field is one of all fields.The fastest growth rateYes.

(9) Hypertension Anti-hypertensives is the ninth largest market segment, and the CAGR in 2016-2022 is-0.2%Will reach in 2022.244Billion dollarsSales, accounting for global market share2.2%.

（10）Cardiovascular Anti-coagulantsIt is the tenth largest market segment, and the CAGR in 2016-2022 iseight.6%Will reach in 2022.232Billion dollarsSales, accounting for global market share2.1%.

By 2022,Top Five Top5 Tumor DrugsWill beCelgeneThe company’s immunomodulatorRevlimid、BMScorporatePD1 antibody Opdivo, Merck’sPD1 antibody Keytruda、AbbViecorporateBTK inhibitor Imbruvica、PfizercorporateCDK inhibitor Ibrance. The next five years will bePD1The overbearing world adds up to the tumor market.10%.

4. How much does it cost to develop new drugs?

First of all, the big pharmaceutical companiesAt present, R&D investment has accounted for about 20% of the sales revenue ratio.. Without research and development, there will be no new products, and cruel competition will push you out of the market.

Secondly,On average, each new drug NME(New Molecular Entity) costs $5 billion.. $5 billion is definitely not a small figure, which exceeds the previous cost.

Furthermore, according to the sales in the United States after the approval of the new drug,The annual sales of each NME in the fifth year is about $522 million.. According to the current Hacth-waxman Act, the new drug NME has5 years of data exclusivityandThree years of market exclusivity,　After that, generic drugs went on the market. It is necessary for pharmaceutical companies to expand indications, conduct more research and development, or cooperate in research and development as soon as possible.

5. Who are the top ten pharmaceutical companies?

First place,Novartis NovartisIn 2016-2022, CAGR is3%, sales reached in 2022.49.8 billion dollars, accounting for market share4.7%.

Second place,Pfizer PfizerIn 2016-2022, CAGR is1%, sales reached in 2022.49.7 billion dollars, accounting for market share4.7%.

Third place,Roche RocheIn 2016-2022, CAGR is4%, sales reached in 2022.$49.6 billion, accounting for market share4.7%.

Fourth place,Sanofi sanofiIn 2016-2022, CAGR is3%, sales reached in 2022.$41.7 billion, accounting for market share3.9%.

Fifth place,Johnson&JohnsonIn 2016-2022, CAGR is4%, sales reached in 2022.$40.5 billion, accounting for market share3.8%.

Sixth place,Merck&CoIn 2016-2022, CAGR is1%, sales reached in 2022.$38.5 billion, accounting for market share3.6%.

Seventh place,AbbVie in AbbwayIn 2016-2022, CAGR is5%, sales reached in 2022.$34 billion, accounting for market share3.2%.

Eighth place,GlaxoSmithKlineIn 2016-2022, CAGR is3%, sales reached in 2022.$33.7 billion, accounting for market share3.2%.

Ninth place,AstraZeneca AstraZenecaIn 2016-2022, CAGR is5%, sales reached in 2022.$28.4 billion, accounting for market share2.7%.

Tenth place,Xinji pharmaceutical CelgeneIn 2016-2022, CAGR is15%, sales reached in 2022.$26 billion, accounting for market share2.5%.

It can be seen that the top three are very tight, and the rankings have not changed much. Pfizer has retreated to the second place, Novartis has jumped to the first place, and Roche is still firmly in the third place.

Gilead fell out of the top ten.

Celgene jumped 11 places into the top ten.

This article was originally published on WeChat WeChat official account’s "Investment and Life of the Owner of Q Village".

A large car of 919,000 yuan that is suitable for driving home for the New Year, which one is the most worth choosing？

The change in shape design is still relatively positive, and the new model looks more fashionable. The lower grille is enlarged and matched with the "BMW" logo, which makes the gas field of the front face of the vehicle look domineering, and the slender headlights look very energetic after being lit. Judging from the waistline on the side of the car body, the new car is still a solemn appearance, and the tradition of wide C-pillar can be continued. In addition, with the design of 20-inch multi-frame wheels, its sports atmosphere is more intense. The horizontal development of the duck tail with two long and slender taillights is more stable, and the details of the through taillights have become more beautiful after being redrawn.

In the car, the new car adopts BMW’s latest design style and layout, which is very harmonious as a whole. Configuration is definitely one of the strengths of BMW 7 Series. The car is equipped with an electric four-way adjustable leather steering wheel and a shift paddle, which is very practical. The center console is made of plastic and leather, and the materials and workmanship look quite satisfactory. The front row is also equipped with a dual-temperature automatic air conditioning control system to freely debug the most comfortable space atmosphere. Leather seats look cute.

The length of the BMW 7 Series is 5391mm, the body width is 1950mm and the wheelbase is 3215mm, which is quite satisfactory. In the same class, the wheelbase of the BMW 7 Series ranks 12th. As a car, its body size does not occupy much advantage in its class, and its internal seating space is only basically enough. After all, it is limited by the length and shape of the car body. The design of skylight also increases the subjective space feeling of front and rear passengers. Among the models of the same price and class, the trunk volume of BMW 7 Series ranks 23rd. Spatial performance is limited by vehicle positioning, and the performance is acceptable, and the flatness is no problem, but the total space is average.

The BMW 7 Series is equipped with a combination of 3.0 turbocharged engine (direct injection) and automatic manual (AT). The power performance of 3.0 engine matched with BMW 7 Series is quite satisfactory, the low torque is weak and the hysteresis can be felt. The official measured acceleration of the BMW 7 Series is 5.4S, ranking 20th among more than 800,000 car models.

The active/passive safety configuration of BMW 7 Series is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

If the above data and participation can’t fully understand the BMW 7 Series, then we can give you a more comprehensive reference based on the word-of-mouth information of users who have purchased the BMW 7 Series in history. It can be seen that what everyone is most satisfied with the BMW 7 Series is that its acceleration is very stable. In addition, the interior is very good and the seats are delicate, which is what everyone likes about it.

Taiwan Province film tutor Peggy Chiao： The fifth generation directors don’t understand genre films.

Peggy Chiao and mainland filmmakers

Ruan Lingyu.The script also comes fromPeggy ChiaoWith Qiu Dai Anping’s hand

Hung Chiu Ping worked as a producer for Cai Mingliang and others.

　　 Studying in the United States in the 1980s,Peggy ChiaoChina films were chosen as the research object, and in the following two or three decades, she served as a judge, guest and curator of international film festivals, constantly promoting the dialogue between Taiwan Province and even Chinese films and the international community. She often thinks that the title of "godmother" in the film industry is inaccurate. However, in the past 30 years, she has always been closely related to the Chinese film industry, from her cooperation and solidarity with Taiwan’s new film movement to her acquaintance with mainland filmmakers. It has been more than ten years since we entered the 21st century. How to treat the transformation bottleneck of the fifth and sixth generations of directors who knew about childhood? What kind of power contrast will cross-strait films that once faced each other across the sea show after integration and development? There is still her keen eye behind all this.

Zhang Yimou was influenced by Crouching Tiger, Hidden Dragon, and produced such works as Hero and House of Flying Daggers.

Chen Kaige has been adjusting himself from "Promise" to "Search".

On the embarrassing situation of the "fifth generation"　Zhang Yimou and Chen Kaige don’t know the tradition of genre films.

　　 In 1988, Peggy Chiao met the "fifth generation" filmmakers from China, such as Wu Ziniu, Tian Zhuangzhuang, Zhang Yimou, Gu Changwei and Gu Changning, at the film festivals in Tokyo and Hongkong respectively. The estrangement has been long, and the filmmakers of the two "camps" have met each other for a long time. More than twenty people often sit on the floor in hotel rooms, smoking and talking about movies all night. As a result, they are complained by hotel guests for a while, and the fire alarm of hotel employees is caused by smoke for a while. The era when people still need to chip in to buy leather jackets for Zhang Yimou and bags for Gong Li, the era when RMB and NT were exchanged and signatures were given to each other, such as "Zhang Bandit’s Art Plan", "Tian Bandit’s Strong" and "Jiao Bandit’s Strong Screen", maybe it should really be called the innocent era of Chinese movies. Times have changed. In the era of billion-dollar clubs, when a phone call has to be transferred through seven or eight people, Peggy Chiao’s observation of these great directors is still not far away.

　　 Reporter: You have always had a close relationship with mainland filmmakers, such as the "fifth generation" directors who knew from childhood. What do you think of their performance in creation and market in recent ten years?

　　 Peggy Chiao: You know, times are changing too fast. At that time, everyone’s creative goals, motivations and practices were relatively simple. Therefore, everyone is willing to do the only consideration in order to create this matter. For example, at that time, what the "fifth generation" directors wanted to do most was to make movies, or to innovate the film language. However, the times have changed so much. During this decade, China’s film industry has made rapid progress, and the situation of Taiwan Province’s films and the mainland has changed like a roller coaster. So in fact, it is not only their "fifth generation" directors who are questioning the changes in the whole system. Everyone in every link is learning the new industrial environment. So this process is so challenging for everyone that each of us may have different decisions and steps. Some directors are like Zhang Yimou, who was influenced by him in those years.Crouching Tiger, Hidden DragonThe drastic influence on the industry, so he will devote himself to the changes in the industry, which is like following and even. Then he has been groping for the creation and role he should play in the changing environment. In fact, he is also very representative.

　　 Reporter: How do you evaluate the gains and losses of Zhang Yimou’s exploration of commercial blockbusters in the past ten years? Because until 2011, there were some criticisms in the mainland.

　　 Peggy Chiao: I think he doesn’t have enough information under this changing choice. For example, "flowers of war" is a very good theme, but he has some, er, this is actually my responsibility as a producer. The producer can form a very good pulling relationship with the director between grasping the direction and creating, but they can’t. This pulling relationship is positive and benign, and should not be negative and malicious. Usually, if the producer and the director are very accurate in the creative direction and field effect, it is actually a very good balance, because it is a bad phenomenon for the director to be bigger and the producer to be bigger. My feeling is that they are in an unbalanced state now.

　　 Reporter: Now we can see that he has the possibility of adjustment. For example, the partner is no longer Zhang Weiping.

　　 Peggy Chiao: He has changed. But I think people around Zhang Yimou should help him find more opportunities and more favorable partners, instead of choosing the market completely, which is the basis for choosing partners.

　　 Reporter: What about Chen Kaige and Tian Zhuangzhuang’s exploration in these years?

　　 Peggy Chiao: Everyone made a move. It was a decision he made at that time. Like kaige, even later, up to now, he has been adjusting. Then I feel strong, you seeSpring in a small townHe insisted on, and his steps have been changing. Therefore, I have two views on them. One is that I think many mainland friends don’t understand them or criticize them fiercely. Then I hold a similar view. Everyone is looking for a way out in this environment, but this responsibility is not theirs. They are also individuals in the middle of the system. Because the dominant people are changing, and now it is definitely the cinema and film dealers who are dominant, the director needs to have the compromise or anger that Director Tong Wang said, and you have two or more ways to fight. On the one hand, everyone has a lot of moral criticism on them, as if their decision to invest in industry is a surrender to money and interests. I will say that from the perspective of empathy, because film is a way of his creation, he must seek a proper position in this system. But on the other hand, I also think that they may have information problems in the steps of reform, and they may have some deficiencies in decision-making. For example, if you know enough about commercial movies, you don’t know much about the traditions of certain types of movies. When he rushed into this place, he actually needed more information, otherwise his judgment was probably inaccurate. This is where I expect them to strengthen.

Next page:Analysis of the future of the "sixth generation" Jia Zhangke, they are facing a crisis of confidence, and the current transformation is crucial.

Strictly crack down on illegal registration of real estate! Ministry of Natural Resources： Strictly prevent the legalization of small property houses.

　　CCTV News:At present, the real estate registration system has been fully operated in the whole country. During a period of operation, there are some difficulties in obtaining certificates in real estate registration in some places. Recently, the Ministry of Natural Resources has deployed a special rectification of the style of the real estate registration window throughout the country.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of the unified registration system for real estate, there have been 109 halls in China, and there have been problems of queuing in the early morning and scalpers changing their numbers. Some places have turned a blind eye to the gap between the service ability and level and the people’s demand for permits, and have not taken the initiative to solve it in time, which is simply limited."

　　The rectification deployment focuses on the style of real estate registration window, such as "pushing around and dragging" and "difficulty in obtaining a certificate". It will take three months to comprehensively promote the "reduction of certificates and convenience for the people" nationwide, and clean up and cancel the pre-existing links without legal and regulatory basis. At the same time, it is necessary to comprehensively clean up all kinds of unnecessary certificates such as "wonderful" certificates, circular certificates and repeated certificates that bother enterprises and the masses.

　　Wang Guanghua, Vice Minister of Natural Resources: "Those materials that can be obtained through the Internet shall not be submitted repeatedly by the masses. Then in fact, the information that can be obtained through information sharing between government departments is fast, accurate and reliable, so it is beneficial to improve efficiency and ensure quality. "

　　In terms of establishing a standardized service system in an all-round way, the Ministry of Natural Resources said that all localities should classify and establish standardized and simplified standardized business processes to provide clear guidance for the masses to do things.

　　Wang Guanghua, Vice Minister of Natural Resources: "There is no pre-position for real estate registration. As long as the application materials submitted by the applicant meet the requirements of the provisional regulations on real estate registration and the detailed rules for the implementation of the provisional regulations on real estate registration, the real estate registration agency should handle it, and the sharing and collaboration between departments should be placed in the window. Don’t let the people run back and forth."

　　Issues left over from history should not be shelved for a long time.

　　According to the Ministry of Natural Resources, for the multi-sector decentralized registration period before the implementation of unified registration of real estate, historical problems caused by imperfect and irregular management links should not be shelved for a long time.

　　Wang Guanghua, Vice Minister of Natural Resources: "At present, there are still more than 4.8 million pieces in the country, and the problems left over from the history of decentralized registration have not been solved. In some places, in the face of the outbreak of historical problems, they did not organize forces to focus on investigation and coordination, and directly let the window staff respond, simply because the procedures were incomplete and they could not be handled."

　　According to the Ministry of Natural Resources, all localities should actively discuss and study the problems left over from history with planning, housing construction and other departments, and report to the people’s governments of cities and counties to issue policies to solve them in time to meet the people’s normal demand for accreditation.

　　Strictly investigate violations of laws and regulations for real estate registration　

　　In addition, the Ministry of Natural Resources also emphasized that it is necessary to prevent "small property houses" from being legalized through real estate registration. At the same time, it is necessary to crack down on the abuse of power to forge false registration of materials, deliberately misregister, illegally register for financing, maliciously collude with illegal registration and disclose registration information.

　　Wang Guanghua, Vice Minister of Natural Resources: "Since the implementation of real estate registration, a total of 303 cases of illegal registration have been found throughout the country. In recent years, the state land supervision agency found that some places illegally and falsely registered mortgages for public welfare roads, parks, public facilities and other land for financing needs, and some places maliciously colluded with third parties to register illegally and leaked registration information."

Revealing the Olympic etiquette, Miss Devil Training, this is the campus flower garden.

Miss Etiquette who appeared in the Good Luck Beijing Test Competition

Miss Olympic etiquette with outstanding charm (data picture)

Hard training (source: competitive newspaper)

　　Youth Daily News Get off the Badaling Expressway at Xiaotangshan exit, head east for 3.5 kilometers, and finally find Songlanbao in sha he, Changping District, Beijing. The taxi stopped at the silver-gray gate of Changping Vocational School in Beijing. It happened that the bell rang after class, and dozens of attractive beautiful students filed out. The volunteers of Beijing Olympic Games ceremony-commonly known as "Miss Olympic Etiquette"-were trained here. What kind of hardships are behind the beauty and elegance?

　　This is the campus flower garden.

　　Since June this year, 1,250 girls from Beijing have come to Changping Vocational School to participate in intensive Olympic etiquette training. Their official name is "Beijing Olympic Games ceremony volunteers", and the popular saying is "Miss Etiquette".

　　After 18-day intensive training, these miss etiquette candidates have been participating in the ceremony service of the 2007 "Good Luck Beijing" Olympic Games series since August. After the examination, 380 etiquette volunteers will be selected in mid-December to participate in the ceremony of awarding the Beijing Olympic Games.

　　On December 5th and 6th, the reporter visited Changping Vocational School twice to visit this "beauty concentration camp" far away in the suburbs of Beijing. Teacher Fu from the school office told the reporter that there are many beautiful women in Changping Vocational School, but this time there are more beautiful women who come to participate in the Olympic etiquette training, which are basically the beauty of various schools. Therefore, it has almost become the big garden of Beijing campus flower!

　　Devil training at 5: 00 a.m.

　　The reporter got a "volunteer training schedule", and the training intensity arrangement above simply exceeded the college entrance examination students!

　　At 5 o’clock every morning, the girls get up and tidy up the house; It is morning exercise time from 6: 00 to 7: 10, and the girls practice gymnastics, dance and basic skills with the tutor; After a simple breakfast, class begins at 8: 00, and an hour of basic ballet hand exercises and body training begins; At 9: 30, the etiquette class starts for two and a half hours, practicing etiquette actions such as standing, walking, walking and turning.

　　Take a simple rest at noon, and start practicing classical dance and folk dance at 14: 00 pm to train the coordination and flexibility of the body, with a total time of about 90 minutes; At 15 o’clock, a two-hour etiquette class begins, the content of which is to consolidate what was learned in the morning. Don’t think that you can rest after class. There will be a 90-minute evening class starting at 19: 00, and the content will be a lecture on Olympic knowledge and etiquette.

　　Busy every day until 22 o’clock at night, these candidate hostesses can return to the dormitory to rest. Teacher Yuan Chunyan, who is in charge of the training of volunteers in awarding ceremonies, said: "When it’s time to rest, the girls don’t even have the strength to go to the bathroom to freshen up, so they can fall asleep when they fall on the bed. For them, these efforts and efforts are aimed at being selected into the final’ Miss Etiquette National Team’ and being perfect when serving the Olympic Games. "

　　Practice smiling by biting chopsticks.

　　The hostesses who participated in the training came from various schools in Beijing, and most of their majors were related to the service industry. They had long been comfortable in reception work. Just because of the particularity of the Olympic Games, we have to strive for perfection and grasp every detail.

　　Teacher Yuan Chunyan told the reporter: "The training of ceremony volunteers is basically the same as that of flight attendants, but it is more strict." Teachers should dig every detail. "For example, when awarding prizes, several volunteers turn around at the same time, and their steps should be consistent. For example, when bowing flowers, the forward direction is about the hip joint and the downward direction is 15 to 30 degrees. Because there are many people in a group when presenting flowers, there are often cases of inconsistent time and irregular movements when squatting, so it is required to have a consistent beat in mind. "

　　The simple steps of holding a medal tray are also very particular. Teacher Yuan Chunyan said: "The arm holding the tray is about one punch away from the side waist. When holding the tray, the thumb must be exposed outside the tray. The most difficult thing is to control the pace and connect the awards. After walking a certain distance during the award presentation, the spacing between them should be the same, about thirty or forty centimeters. "

　　Hao Jingyu, a etiquette volunteer, said: "What impressed me the most was practicing standing, walking, walking, turning around and smiling in etiquette training. In order to make our posture more upright, pace more in place, turn more neatly and smile more naturally when awarding prizes, we have to practice each movement hundreds of times. For example, standing posture is not as simple as we thought. Every etiquette volunteer must wear 5 cm high heels, a book on his head, and an ordinary piece of white paper between his legs and knees. One stop is an hour, and neither books nor papers can fall off, or they will have to be redone. When I rest, my legs are particularly painful to bend. "

　　"Another example is practicing smiling. The smile of volunteers is the best business card in Beijing, so it is very important. " Hao jingyu said, "the laughter needed at the award ceremony is very different from our usual laughter. It is not acceptable to open your mouth wide or small, and even the number of exposed teeth is strictly regulated at 6 to 8. The teacher asked each of us to bite a chopstick in our mouth to feel when practicing smiling. It takes dozens of minutes to laugh like this, and even the facial muscles are numb. "

　　After practicing for a long time, the girls’ teeth are sore by chopsticks, and the corners of their mouths are often abraded. Parents can’t help crying when they see the wound, and the girls smile and comfort their parents with a "nothing". Hao Jingyu said, "It’s the same when practicing walking, walking speed, turning around and other decomposition exercises. Everyone’s feet are ground with blisters, large and small, and after the blisters are worn out, they are ground with new blisters. So on and on, our movements are finally uniform."

　　Daily food allowance for 25 yuan

　　Girls don’t get much material gains by participating in Olympic etiquette activities. The only subsidy for three meals a day for the volunteers participating in the training is 25 yuan, which is almost the same as the dietary standard of ordinary people.

　　Girls have more than a dozen kinds of food for breakfast every day, such as steamed buns, eggs, soybean milk, porridge and Chinese buns. Chinese food and dinner are staple foods such as rice, steamed buns and steamed buns, plus reasonable collocation of vegetables, meat and fish. Teacher Yuan Chunyan said that this recipe should not only ensure that the ceremony volunteers absorb enough nutrition, but also prevent them from getting fat due to overnutrition and affecting their body image. During the early training, there were many mosquitoes in hot weather. The school specially installed air conditioning for the student dormitory of the ceremony volunteers, and prepared mosquito-repellent incense tablets and pesticides to prevent scars from mosquito bites.

　　Teacher Cui Weimin, deputy director of aviation service major in Changping Vocational School, told the reporter that the formal training will continue until March 2008. After intense training, it is the wish of volunteers to see their idols with their own eyes. Hao Jingyu said: "My idol is Liu Xiang. When I imagine that I may have the opportunity to serve Liu Xiang, I even have tears in my eyes, and I silently pray’ 2008, come soon’!"

　　Never flinch from suffering.

　　Despite strict training, accidents will inevitably occur in the actual operation process. When participating in the "Good Luck Beijing" archery team competition, a ceremonial volunteer accidentally stepped on the drainage pipe and twisted it. In order not to affect the progress of the award ceremony, she still kept an elegant smile, guided the award officials to walk the whole field, and walked back to the locker room only to find that the heel almost fell off completely.

　　More than 30 students from Changping Vocational School have participated in the etiquette service of the "Good Luck Beijing" series of events. In order to prepare for the "Good Luck Beijing" triathlon, the etiquette team of Changping Vocational School was pulled to the competition site for training. In those days, the temperature in Beijing just plummeted and the cold rain continued, and the players wearing short-sleeved dresses had to keep training in the cold wind and cold rain. It’s really cold, so everyone happily hugs together to keep warm during the interval of training. Despite the suffering, none of the girls flinched in order to have a good performance at the award ceremony.

　　Liu Changwen, a volunteer who awarded the prize for the "Good Luck Beijing" hockey competition, told the reporter: "My tray contains 18 gold medals and a trophy for the hockey competition, which is estimated to weigh at least 10 kilograms. At first, my hands were shaking. I was particularly afraid that shaking my hands too much would make the medal fall, but I finally persisted! " After the awarding ceremony, a member of the champion Australian team went to the rest area of Miss Etiquette and gave her champion flowers to Liu Changwen. "I was very excited at the time and felt that this was the best evaluation for our entire etiquette team!"

　　How is Miss Olympic Etiquette selected?

　　China has a population of 1.3 billion, so it is not difficult to select thousands of beautiful women. However, Miss Olympic Etiquette is called one of the "facades" of an Olympic Games, and it is not sloppy at all. Not all beautiful women meet the standards of Miss Olympic Etiquette.

　　According to Zhao Dongming, director of the Cultural Activities Department of BOCOG, the standard of a hostess for the Beijing Olympic Games is "1.68m to 1.78m in height and 18 to 25 years old". Zhao Dongming said that miss etiquette must first be an Olympic volunteer; Secondly, the figure is better, and there is no strict regulation on the weight, but there are certain guiding standards for the measurements, because it involves the production of award-winning dresses.

　　There will be nearly 100,000 volunteers for the Beijing Olympic Games, but among these 100,000 volunteers, it is difficult for other volunteers to experience what Miss Etiquette has experienced. Since the beginning of June, BOCOG has been selecting etiquette volunteers in many schools in Beijing. On the basis of various hard indicators, each school chose the best among the best, and conducted an all-round personal quality evaluation for each candidate. The selected candidate not only has outstanding appearance, but also has excellent academic performance and certain English conversation ability. The organizers also have strict requirements on the temperament, posture, skin and comprehensive quality of the candidates.

　　During the selection in China Civil Aviation Management Cadre College, the school held a etiquette selection contest, especially in the whole school. More than 400 girls competed for 10 places, and the competition was fierce.

Editor: Zhu Xinrui

Pentium pony is about to attract brand-new models, so it’s really comfortable to have large space.

Space and vehicle comfort are closely related, and this car is brought to you today. Let’s take a look at it together.

First look at the appearance of the Pentium pony. The front of the Pentium pony looks very simple and generous, which makes people unforgettable. Coupled with tough headlights, it is very eye-catching. The car is equipped with etc. Come to the side of the car, the car body size is 3000MM*1510MM*1630MM, the car uses dignified lines, the car side looks very calm, with large-sized thick-walled tires, the shape is quite dignified. Looking back, the tail line of Pentium pony is fashionable, the taillights are very domineering and the shape is relatively simple.

In terms of interior, the interior modeling has taken a solid route and the visual effect is quite unique. The car looks very good outside the steering wheel, made of plastic, and feels good. Take a look at the central control. The design of the center console is reasonable, which makes the interior design quite layered, which is in line with the temperament of the car. Let’s take a look at the dashboard and seats again. The dashboard of this car presents a flamboyant design style, which is very eye-catching. The car uses a fabric seat, which is wrapped in place and has good support and comfort.

Pentium pony matching gearbox, 30KW, 90N.m, good power performance.

The car is equipped with Bluetooth /WIFI connection, sun visor mirror, USB interface, uphill assist, rear reversing radar and other configurations, which is quite rich in functions, which is undoubtedly very friendly to drivers.

After reading the above description, Xiaobian will make a summary. I wonder if you are excited about this car introduced today?

Notice of Beijing Municipal Bureau of Economy and Information Technology on Organizing the Publication of the Second Batch of Foundation Construction Projects for High-tech Industries in 2023

　　In order to implement the decision-making arrangements of the municipal party committee and the municipal government on upgrading the modernization level of the industrial chain supply chain, and accelerate the construction of an international science and technology innovation center, according to the deployment of the "Development Plan for High-tech Industries in Beijing during the Tenth Five-Year Plan", based on enhancing the independent and controllable capabilities of the industrial chain and supply chain, focusing on the weak links of the industry, and carrying out the engineering research on key basic technologies and products, the second batch of high-tech industry foundation projects will be organized and unveiled in 2023.

　　First, the research direction and support standards

　　(A) the direction of tackling key problems

　　1. The field of hydrogen energy

　　(1) Direction of combined valve of 1)70MPa automobile hydrogen bottle

　　2. Field of medical robots

　　(1) High real-time tracking and intelligent navigation device for surgical robot.

　　(2) Robot intelligent mobile platform

　　(3) fracture reduction operation planning and control system

　　3. The field of cell and gene therapy drugs

　　(1)GMP-level transfection reagent

　　(2) Cell cryopreservation solution

　　(3) Cell reprogramming reagent

　　(4) Cell cryopreservation bag

　　(5) Large magnetic frame

　　(6) Cell washing, concentration and liquid exchange equipment with ultra-Qualcomm capacity.

　　(7) Gene Transduction Equipment

　　4. Cloud native domain

　　(1)OpenNJet HTTP3 state secret SSL suite module　

　　(2)OpenNJet HTTP3 proxy module

　　(3)OpenNJet MQTT protocol proxy module

　　(4)OpenNJet WASM module

　　(5)OpenNJet HTTP3 proxy enhancement module.

　　(6)OpenNJet dynamic protocol plug-in module

　　5. Database field (distributed relational type)

　　(1) Research and development of key algorithms and module technologies for heterogeneous database migration.

　　(2) Supporting standards

　　For the project units registered in our city, support shall be given according to 30% of the investment for tackling key problems approved by the project, and the amount of support in a single direction shall not exceed 30 million yuan, and the funds shall be allocated annually.

　　Second, the reporting requirements and instructions

　　(a) reporting conditions and requirements

　　1 to encourage enterprises and consortia with the ability to tackle key problems nationwide to expose the list. The party receiving the list should be in good operation and financial condition, and have no serious record of dishonesty in the past three years.

　　2. The construction site of the project is in this city, which meets the requirements of this city’s industrial policy and has complete procedures. The research period should not exceed 3 years, and the start time should be later than January 1, 2023.

　　3 to declare the project should not be supported by other municipal financial funds.

　　4. The applicant shall submit the application materials as required. The applicant voluntarily fills in relevant materials, promises relevant matters, and is responsible for the authenticity and accuracy of the materials provided.

　　(2) Time and process of declaration

　　1. Detailed indicators and parameters of the research direction can be obtained by consulting the corresponding business offices in each direction (see Annex 2 for details).

　　2. Eligible reporting units, please submit the materials (three sets of paper version and one set of electronic version) to the corresponding business offices in all directions as required (see the annex for details) before October 20, 2023. Paper version materials shall be made in accordance with A4 paper binding, and the cover and riding seam shall be stamped with the official seal of the project reporting unit.

　　(3) Other matters

　　1. The project unit shall carry out project management in accordance with the Measures of Beijing Municipality for the Management of Development Funds for High-tech Industries, and accept the follow-up inspection, acceptance review and performance supervision by the relevant departments of the urban area, such as the letter, finance and so on. In case of concealment, concealment, fraud or violation of commitments, Beijing Economic and Information Technology Bureau has the right to pursue relevant legal responsibilities and recover funds. At the same time, it will incorporate the untrustworthy information of the project unit into the Beijing public credit information service platform and implement credit punishment according to laws and regulations.

　　2. Contact person for policy consultation:

　　Planning Department: Zong Zhigang, 55578586; Zou Genhong, 55578179.

　　Technical support: customer service staff of Beijing Tongqi Service APP, 82176966; Beijing high-tech industrial development fund system operation and maintenance personnel, 55578555.

National Health Commission： Strengthen the coordinated development of medical insurance and medicine

At the press conference held by the National Health and Wellness Committee on February 28th on the progress and effectiveness of health and wellness, Mi Feng, spokesperson of the Committee and deputy director of the Propaganda Department, introduced that the main health indicators of Chinese residents are currently in the forefront of middle-and high-income countries.

Continuously meet the health service needs of the people.

Zhuang Ning, deputy director of the Department of Physical Reform of the National Health and Wellness Commission, said that in recent years, the National Health and Wellness Commission has actively played a leading and coordinating role in medical reform and strengthened the coordinated development of medical care, medical insurance and medicine with relevant departments.

Zhuang Ning introduced that in terms of medical care, through the layout and construction of national medical centers, national regional medical centers, and provincial regional medical centers, we will strengthen relevant clinical key specialties and solve the problem of people seeking medical treatment across regions. According to statistics, in the first four batches of 76 national regional medical centers, more than 460 specialties have been built and more than 6,200 new medical technologies have been developed, and the average number of patients transferred to hospitals has dropped by about 30% compared with that before construction. The rate of common and frequently-occurring diseases in the county is over 90%.

Public hospitals are the main body of China’s medical service system. According to Jiao Yahui, director of the Department of Medical Administration of the National Health and Wellness Commission, there are 2,817 tertiary public hospitals and 5,384 secondary public hospitals participating in the performance appraisal of public hospitals nationwide. According to the data of the past five years, the development mode, operation mode and resource allocation of tertiary public hospitals in China are more reasonable. The two indexes reflecting the technical difficulty of medical services, namely, the case combination index and the proportion of discharged patients in Grade IV surgery, have increased by 10% and 23.5% respectively, and the application level of electronic medical records in 83% tertiary public hospitals has reached Grade IV or above. The number and proportion of doctors in short supply such as anesthesiology, pediatrics, and severe diseases in tertiary public hospitals across the country have increased, constantly meeting the needs of people’s health services.

Zhuang Ning said that in terms of medical insurance, China has further improved the universal medical insurance system, raised the per capita financial subsidy standard for residents’ medical insurance to 640 yuan, and continuously improved the level of general outpatient medical insurance for employees. In medicine, we will further expand the breadth and depth of centralized procurement of pharmaceutical consumables and further reduce the inflated price. Revise and improve the medical insurance drug list, improve the basic drug system, speed up the registration and listing of urgently needed drugs, children’s drugs and innovative medical devices, and strive to meet the people’s drug demand.

Continuously improve the ability of disease prevention and control

In recent years, China has continuously improved the multi-sectoral cooperation mechanism to enhance the ability of disease prevention and control. Qin Xingqiang, deputy director of the Comprehensive Department of the National Bureau of Disease Control and Prevention, said that the laws, regulations and policy systems related to the emergency response of infectious diseases in China have been continuously improved, and the emergency management system and mechanism have been continuously optimized, basically forming an emergency plan for public health emergencies, covering multiple diseases and covering national, provincial, municipal and county levels. Relying on the national and provincial centers for disease control and prevention, 20 national teams for the prevention and control of sudden acute infectious diseases have been set up, covering 17 provinces.

According to reports, since the "14 th Five-Year Plan", the central budget has allocated a total of 13.1 billion yuan to support the construction of disease control systems at the national, provincial, municipal and county levels. In 2023, the central government allocated 17.687 billion yuan for disease control projects through transfer payment for the prevention and control of major infectious diseases and endemic diseases.

Qin Xingqiang said that at present, the average reporting time of China’s infectious disease network direct reporting system has been shortened from five days to four hours now. At the national level, a technical system for rapid identification of 300 pathogens within 72 hours has been established, and 100% of provincial and 90% of municipal CDC have the ability to detect nucleic acids and isolate viruses. In the prevention and control of major infectious diseases, the rapid rise of AIDS epidemic in key areas has been effectively curbed; The mortality rate of tuberculosis remains at a low level; All endemic counties of schistosomiasis have reached the state of transmission interruption; Measles, Japanese encephalitis and other vaccines can prevent the incidence of infectious diseases from falling to the lowest level in history.

Construction of 321 high-level key disciplines of traditional Chinese medicine

In order to promote the development of China’s traditional Chinese medicine service system, Ouyang Bo, deputy director of the Comprehensive Department of the State Administration of Traditional Chinese Medicine, introduced that the State Administration of Traditional Chinese Medicine, the National Health and Wellness Commission and the National Development and Reform Commission took the lead in establishing an inter-departmental working mechanism with relevant departments, and the central government invested nearly 13 billion yuan to promote key tasks and major engineering projects to basically achieve "double half".

Ouyang Bo said that China’s traditional Chinese medicine inheritance and innovation has been steadily promoted-46 national traditional Chinese medicine inheritance and innovation centers have been built, and 50 superior diseases treated by traditional Chinese medicine, 52 integrated Chinese and Western medicine diagnosis and treatment programs, 100 appropriate technologies and 100 Chinese medicine varieties with unique curative effects have been selected and released. The official publication of the first batch of 74 books in the "Chinese Medical Collection" marks a major stage achievement in the compilation of ancient Chinese medicine books.

At the same time, the team of talents with Chinese medicine characteristics has been growing, training 50 Qihuang scholars, 500 national outstanding clinical talents of Chinese medicine, 100 young Qihuang scholars, 35 innovative teams of Chinese medicine, and building 321 high-level key disciplines of Chinese medicine.

According to preliminary estimates, in 2023, the total number of medical treatment in Chinese medical and health institutions was 1.28 billion, and the number of discharged patients was 41.486 million. Chinese medicine played an active role in serving people’s health.

Building a high-quality and efficient Chinese medicine service system is one of the main tasks of the development plan of Chinese medicine in the 14 th Five-Year Plan. In this regard, Ouyang Bo said that the State Administration of Traditional Chinese Medicine aims to achieve high-quality Chinese medicine services for everyone nearby, promote 14 Chinese medicine hospitals to be included in the founding unit of the National Medical Center, lay out and build 27 national regional medical centers for Chinese medicine, and continue to promote the construction of 62 "flagship" hospitals and 138 key hospitals with Chinese medicine characteristics. At the same time, optimize the supply of Chinese medicine services, select about 1,000 national traditional Chinese medicine specialties and 500 "flagship" departments for the coordination of Chinese and Western medicine, determine 31 units for the construction of Chinese medicine rehabilitation centers, strengthen the construction of pediatrics and geriatrics departments in Chinese medicine hospitals, and promote the construction of outpatient clinics for Chinese medicine specialties; Taking the construction of county-level Chinese medicine hospitals as the leader, we will build a solid grassroots network, promote tertiary hospitals to help 699 county-level Chinese medicine hospitals, and achieve full coverage of grassroots Chinese medicine museums in 23 provinces, so as to facilitate the masses to take a good look at Chinese medicine at their doorsteps.(Reporter Jin Zhenya)

More than 8 models of Tiggo were exposed to brake failure, and the problem pointed to brake by wire!

If you are the owner and prospective owner of Tiggo 8 PRO or Tiggo 8 PLUS, please note that there is something wrong with Chery’s brake-by-wire technology.

Recently, Master Jiao learned from relevant channels that Chery’s brake-by-wire technology has brought troubles to many car owners. The specific performance is as follows: 1. There will be a buzzer when braking; 2. The brake pedal becomes hard; 3. Brake failure; 4. Brake jitter. At present, it is understood that some car owners have formed rights protection groups and shared fault cases in the groups.

Please step on the brakes when the vehicle starts, but the owner has been stepping on the brakes.

The corner master found that a car owner was driving at a low speed of 30 kilometers per hour, and suddenly the brake pedal rebounded, and then a fault code appeared in the dashboard. At this time, the brake pedal felt hard and the hard-vegetable pedal vehicle appeared jitter.

At present, the official has not responded to this problem, and the owner has locked the root of the problem in the brake-by-wire technology. Because some owners of Tiggo 8 PRO and Tiggo 8 PLUS do not have such problems, the problem owners are mainly concentrated in the vast version of Tiggo 8 PRO and Tiggo 8 PLUS pride+,so what is Chery’s brake-by-wire technology?

In March 2022, Chery Automobile announced a major innovation when it launched the Tiggo 8 PLUS version. The braking system of the car was upgraded and the integrated brake-by-wire system of Bethel WCBS was adopted. The core technology of this system is to integrate the vacuum booster pump, master cylinder, electronic vacuum pump, EPB and ESC. The following figure shows the comparison between the integrated brake-by-wire system module and the traditional vacuum booster pump. Its main purpose is to reduce costs and enhance the competitiveness of products. In addition to cost reduction, the official said that this system can also coordinate energy recovery system and high dynamic pressurization capacity. In other words, most of Chery’s new energy vehicles will adopt the brake-by-wire system in the future.

Integrated brake-by-wire system

Traditional vacuum booster pump

However, at present, it is obvious that the technology is not yet mature, and some car owners equipped with brake-by-wire technology have become "mice". Master Jiao then went to the domestic third-party vehicle quality complaint platform to investigate and found that there have been centralized complaints about the models equipped with brake-by-wire technology in the Tiggo 8 PRO plate, and the most complained car in the Tiggo 8 PLUS plate is Haoqing+,which is also equipped with brake-by-wire technology.

Up to now, Chery officials have not responded to the vehicles with problems in the by-wire control technology. Judging from the problem of concentrated outbreak, Master Jiao’s personal guess may be that there is a problem with a batch of vehicles equipped with wire control technology. The failure of the brake system is a major personal safety hazard, and the manufacturer must attach great importance to it, and it is necessary to complete the upgrade, optimization and even recall of the problem model in a short time.

A few days ago, Chery Automobile just released the sales data in July 2022, and the group’s sales volume was 131,533, a year-on-year increase of 57.7%. This figure successfully surpassed 122,633 vehicles of Geely Automobile and 101,920 vehicles of Great Wall Motor. In terms of splitting, Chery’s total sales volume was 131,533 vehicles, of which 50,614 vehicles were exported, up 90.1% year-on-year. The sales volume of new energy was 25,614 vehicles, a year-on-year increase of 253%. It can be seen that the sales of new energy have surged, and in addition, the export volume has reached a new high. This is the happy side.

However, the safety hazard brought by the brake-by-wire technology hangs over Chery like a time bomb. However, if it is detonated, it will surely face the collapse of product quality reputation, and all efforts will be wasted.

Korean media： Former South Korean President Lee Myung-bak, who is serving his sentence, is hospitalized outside the prison due to illness.

　　[Global Network Report] Yonhap News Agency reported that according to the news of the Korean Ministry of Justice on the 17th, former President Lee Myung-bak, who was detained in Anyang Prison in Gyeonggi Province, was admitted to Seoul National University Hospital the day before for a disease check-up, and the time of hospitalization, discharge and escort was inconvenient to disclose due to security problems.

Profile photo: Li Mingbo was transferred to Anyang Prison. Image source: Yonhap News Agency

　　The Korean Ministry of Justice said that Lee Myung-bak will be examined according to the opinions of the hospital during his hospitalization. According to the report, Lee Myung-bak was treated for diabetes and other diseases, and he was treated outside prison for three times last year. According to reports, Lee Myung-bak was sentenced to 17 years in prison for corruption and bribery, fined 13 billion won (about 69.24 million yuan), and pursued 5.78 billion won in criminal proceeds.

　　It is worth mentioning that another former South Korean President, park geun-hye, was released from prison by amnesty at the end of December, 2021. Her lawyer, Liu Rongxia, said on the 16th that park geun-hye was in better health and would speak to the people when she left the hospital. Liu Rongxia also relayed that park geun-hye was sad that another former president, Lee Myung-bak, was not granted amnesty.

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